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Biomedical subjects

Y Uji

Publications and source records attributed to Y Uji.

99 records · Page 6Linked to original sources
PubMedDate not supplied

The multifocal electroretinogram in retinal detachment.

We evaluated the retinal electrophysiologic function in both the detached and attached areas of eyes with retinal detachment, and assessed the functional recovery of these areas after surgery by quantifying the results obtained from multifocal electroretinograms. Multifocal electroretinographic recordings and central 0 degrees to 30 degrees visual field tests were performed preoperatively and 2 weeks 1, 3 and 6 months postoperatively in 12 patients with unilateral retinal detachment. Each patient's response to the multifocal electroretinogram and the visual field test was classified into two groups: group A, the response from the attached area; and group B, that from the detached retinal area. Individual mean deviation and percentage mean deviation were calculated for each group. All retinal detachments were successfully reattached by the conventional scleral buckling method. The retinal sensitivity in the visual field test of all the patients in group B greatly improved. However, the percentage mean deviation in the response density of the multifocal electroretinogram in group B was -81% preoperatively and -63% at 6 months postoperatively. Thus, the improvement was confined within narrow limits. The response density of the multifocal electroretinogram in group A was very low, and never improved beyond -50% of percentage mean deviation. In the eyes with retinal detachment, clectroretinogram response in both the attached and detached areas was more disturbed than predicted by means of the visual field test during the course of this study.

Adolescent↗
PubMedDate not supplied

Stages III and IV squamous cell carcinoma of the mouth: three-year experience with superselective intraarterial chemotherapy using cisplatin prior to definitive treatment.

PURPOSE: This study was designed to assess the 3-year experience with superselective intraarterial chemotherapy prior to definitive treatment for stages III and IV squamous cell carcinomas of the mouth. METHODS: Twenty-two patients prospectively received superselective intraarterial chemotherapy using relatively low-dose cisplatin via a transfemoral approach. The locations of the tumors were the tongue (n = 12), gingiva (n = 5), buccal mucosa (n = 2), hard palate (n = 1), floor of the mouth (n = 1), and lip (n = 1). After intraarterial chemotherapy, 21 patients underwent surgery (n = 14), radiation therapy (n = 6), or both (n = 1). The survival rate of 25 patients who underwent surgery with/without radiation therapy until 1992 at Kumamoto University Hospital was also evaluated as a historical control. The survival curve was calculated with the Kaplan-Meier method, and the statistical difference between survival curves was determined with the generalized Wilcoxon test. RESULTS: The overall response rate was 95% [complete response (tumor completely resolved), 24%; partial response (tumor reduction > or = 50%), 71%]. Fifty-two intraarterial infusions were performed without any catheter-related complications. Mild and transient local toxicity such as edema or mucositis of the infused area was relatively common. One patient died of renal failure from cisplatin. After a median follow-up of 20 months (range 2-41 months), the estimated 3-year survival rate for patients who underwent intraarterial chemotherapy plus surgery was 91%. The survival of the patients who underwent intraarterial chemotherapy plus surgery tended to be longer than that of the historical control. CONCLUSIONS: Early tumor reduction without delay of subsequent treatments can be obtained by intraarterial chemotherapy while minimizing complications and possibly improving survival. Further investigations of long-term survival with larger series need to be performed.

Antineoplastic Agents↗
PubMedDate not supplied

Comparison between Dawson, Trick, and Litzkow electrode and contact lens electrodes used in clinical electroretinography.

PURPOSE: To determine the reliability of the Dawson, Trick, and Litzkow (DTL) electrode in electroretinographic recordings (ERG) in subjects of all ages, we evaluated ERG responses obtained with the contact lens (CL) and DTL electrodes and estimated a DTL/CL ratio for each sample. METHODS: Seventy-nine volunteers aged 2-84 years (79 normal eyes) were recruited for the study. Electroretinographic recordings elicited by monocular single-flash stimuli delivered by an automatic ERG recording system were recorded using both CL and the DTL electrodes (CL-ERG and DTL-ERG, respectively). RESULTS: The relative amplitude of the DTL-ERG to the CL-ERG was 79.6-99.8% (mean = 93.4%) for the a-wave and 84.4-106.3% (mean = 92.3%) for the b-wave. The relative latency of the DTL-ERG to the CL-ERG was 86. 0-107.6% (mean = 98.2%) for the a-wave and 96.1-113.0% (mean = 97. 9%) for the b-wave. The a- and b-wave amplitudes differed significantly between DTL and CL electrodes only in the 40- to 49-year-old age groups (P <.05). Regression analysis indicated moderate to strong relationships between the electrodes for amplitude (a-wave, r = 0.690; b-wave, r = 0.824) and latency (a-wave, r = 0.667; b-wave, r = 0.725). CONCLUSION: The DTL electrode has as high stability as the conventional CL electrodes for ERG recordings in most age groups.

Adolescent↗
PubMedDate not supplied

Haloperidol effects on Na current in acutely isolated rat retinal ganglion cells.

Suppressive effects of haloperidol, one of the neuroleptic compounds that acts on the transient Na current (INa,t) were studied in freshly isolated 5-10-day-old rat retinal ganglion cells using a whole-cell patch clamp technique. High doses of haloperidol reversibly and dose dependently (2-200 mumol ) reduced the peak amplitude of INa,t. The half-inhibition dose was 27.1 mumol. The inactivation curve of INa,t was shifted toward a hyperpolarizing direction by about 42% when the amplitude was suppressed with 20 mumol haloperidol. This indicates that haloperidol suppression of INa,t is probably affected through changes in the inactivation of Na channels.

Animals↗
PubMedDate not supplied

Central retinal vein occlusion during remission of ulcerative colitis.

BACKGROUND: Retinal vascular disease is a rare complication of ulcerative colitis. CASE: We report a patient who developed unilateral nonischemic central retinal vein occlusion (CRVO) (papillophlebitis) without any other retinal vascular disease during remission of ulcerative colitis. OBSERVATIONS: The best-corrected visual acuities were 1.5 OD and 0.7 OS. Dilated and tortuous retinal veins and retinal bleeding were seen in the left eye. Macular edema and leakage from the papilla and the retinal veins of the left eye were evident on fluorescein angiography. After increased dosage of systemic prednisolone was prescribed, the retinal vascular changes resulting from CRVO (papillophlebitis) in the left eye gradually abated. CONCLUSIONS: Retinal vascular diseases should be monitored during both remission and activation of intestinal symptoms of ulcerative colitis.

Adult↗
PubMedDate not supplied

Ultrasound biomicroscopy dark room provocative testing: a quantitative method for estimating anterior chamber angle width.

PURPOSE: To describe a quantitative method for measuring the iridocorneal angle recess area, and, using this, to evaluate factors associated with appositional angle-closure during dark room provocative testing using ultrasound biomicroscopy (UBM). METHODS: All patients (178 patients, 178 eyes) with clinically narrow angles referred for UBM dark room provocative testing between September 1996 and March 1998 were enrolled in this study. Images of the inferior quadrant of the angle taken under standardized dark and light conditions were analyzed. The angle recess area (ARA) was defined as the triangular area demarcated by the anterior iris surface, corneal endothelium, and a line perpendicular to the corneal endothelium drawn from a point 750 microm anterior to the scleral spur to the iris surface. ARA, and acceleration and gamma-intercept of the linear regression analysis of the ARA were calculated. In the linear regression formula, y = ax + b, the acceleration a describes the rate at which the angle widens from the scleral spur; the y-intercept b describes the distance from the scleral spur to the iris. RESULTS: Under dark conditions, the angles in 99 patients (55.6%) showed evidence of appositional angle-closure during testing. ARA (0.11 +/- 0.04 vs. 0.15 +/- 0.05 mm2, P < .0001, Student t-test), acceleration a (0.22 +/- 0.15 vs. 0.26 +/- 0.17, P = .068), and y-intercept b (66 +/- 46 vs. 92 +/- 47 microm, P = .0003) were smaller in eyes that were occluded. In the eyes that were not occluded, y-intercept b showed no significant difference between light and dark conditions (P = .1, paired t-test), while acceleration a did (P < .0001). In the eyes that were occluded, both decreased significantly under dark conditions (P < .0001). CONCLUSIONS The ARA linear regression formula provides useful quantitative information about angle recess anatomy. The more posterior the iris insertion on the ciliary face, the less likely the provocative test will be positive.

Adult↗
PubMedDate not supplied

Angle recess area decreases with age in normal Japanese.

PURPOSE: To investigate prospectively the relationships between anterior chamber angle configuration and refractive error, axial length, age, and body height in the Japanese. METHODS: We studied 65 eyes of 65 subjects (30 men, 35 women) who were either patients at the Ophthalmology Department of Mie University or volunteers. The 65 subjects underwent a complete eye examination, A-scan biometry, and ultrasound biomicroscopy. Images were exported to an IBM-compatible personal computer in PCX format. The angle recess area (ARA) was measured using a software program of our own design. RESULTS: The ARA decreased with age in all quadrants of all eyes. In older individuals, the angle in the superior quadrant was significantly narrower than in the other quadrants. The ARA correlated directly with anterior chamber depth (P < .001), axial length (P < .001), and body height (P = .003), and inversely with age (P < .001) and refractive error (P = .003) in pairwise analysis. Multivariate analysis revealed a significant association between ARA and anterior chamber depth (P < .001), axial length (P = .016), and younger age (P = .043). CONCLUSIONS: The anterior chamber area narrows with age, especially in the superior quadrant. Narrowing of the angle in Japanese is associated with older age, shorter axial length, and shallower anterior chamber depth. We hypothesize that because of the increasing prevalence of axial myopia in younger Japanese, angle-closure glaucoma could become less common in Japan in the future.

Adult↗
PubMedDate not supplied

MR imaging of lingual carcinoma: comparison with surgical staging.

The purpose of this study was to determine the usefulness of magnetic resonance (MR) imaging for the preoperative staging of 18 patients with lingual carcinomas. Tumor stage as determined by MR imaging was compared with pathological stage. Conspicuity of tumors was compared among dynamic MR, T2-weighted, and postcontrast T1-weighted images. The tumor stage was evaluated correctly with MR imaging in 15/18 patients (83.3%). One patient was overstaged and two understaged due to incorrect diagnosis of size. In all T4 cases, tumor extension was diagnosed correctly. Dynamic MR and T2-weighted images were superior to postcontrast T1-weighted images in delineating and showing the extension of carcinomas. However, dynamic MR imaging showed no significant superiority to T2-weighted imaging. We conclude that MR imaging is of great value in the staging of lingual carcinoma. Dynamic study should be performed only when the lesion is undetectable or equivocal on T2-weighted imaging.

Adult↗