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Biomedical subjects

Y Terada

Publications and source records attributed to Y Terada.

At least 415 records · Page 23Linked to original sources
PubMed1981

[Relationship between vascular diameter and intracardiac pressure in tricuspid or pulmonary insufficiency detected by contrast echocardiography (author's transl)].

In order to evaluate the usefulness of contrast echocardiography in the diagnosis of tricuspid (TI) and pulmonary insufficiency (PI), 30 patients with various heart diseases and 7 controls were examined. The dimensions of the inferior vena cava and pulmonary artery were also measured on the two-dimensional echocardiogram. Cardiac catheterization was performed in 18 patients to study the relationship between the diameters of the vessels and the intracardiac pressures. The following results were obtained. 1) TI was detected without difficulty by contrast method using two-dimensional echocardiography on the four-chamber view. The diagnostic sensitivity was higher than that of conventional methods. 2) PI was also detected by the parasternal approach. The regurgitation of the contrast material across the pulmonary valve was easily confirmed because of pulmonary arterial dilatation. 3) In the cases with TI, the dimension of the inferior vena cava was larger than 20 mm. The right ventricular systolic pressure and the mean right atrial pressure were higher than 40 mmHg and 6 mmHg, respectively.

Blood Pressure↗
PubMed1980

Induction of intestinal metaplasia in the glandular stomach of rats by X-irradiation prior to oral administration of N-methyl-N'-nitro-N-nitrosoguanidine.

CD/CRJ rats were subjected to localized X-irradiation of the stomach and given N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the drinking water. Rats given MNNG alone and non-treated rats were used as controls. Upon sacrifice at 15 months after the initial MNNG administration, intestinal metaplasia was observed; the histology was of complete type and the incidence was 100% in rats treated with X-rays and MNNG, whereas in rats treated with MNNG alone the intestinal metaplasia was of incomplete type and its incidence was 80%. However, the incidence of gastric cancer in rats treated with MNNG alone was 25%.

Adenocarcinoma↗
PubMed1979

A mode of incipient growth in chemically induced signet ring cell carcinoma of the canine stomach.

A 31-month-old female mongrel dog was orally administered with 50 mg or 100 mg of N-nitrosobutylurea (NBU) in gelatin-capsule 3 times per week for 19 months with interposing periods of complete suspension. Thirty-four foci of signet ring cell carcinoma were found in the antral region of the stomach. The majority of the foci (31 foci) were early cancer, and the remaining foci were invasive cancer. In addition to these lesions, there was "a single gland cancer" in which a row of cancer cells was confined to a single gland. The whole gland was composed of two cell layers; the inner layer facing the lumen was normal gastric cells and the outer layer was atypical or neoplastic cells underlaid by the basement membrane. Mitosis was frequently observed on the bottom of the gland. Atypical or neoplastic cells seemed to mature gradually through a process of upward migration with increase in cytoplasmic Alcian blue-PAS and HID-AB positive mucin. Some of the cells rich in mucin moved into the lamina propria. The other cells remained in the flow of the regular cell renewal system of the normal gastric cells and reached the top of the gland. This observation revealed a mode of incipient gastric cancer growth, which starts and spreads within a single gland, before it invades the surrounding lamina propria.

Adenocarcinoma, Mucinous↗
PubMed1977

Induction of atrophic gastritis in ICR mice by the administration of an allogenic antigen.

In an attempt to produce experimental autoimmunity in small animals the experiment was sought to induce atrophic gastritis in ICR/JCL mice. The stomach antigen of ICR mice was extracted and emulsified with an equal volume of Freund's complete adjuvant. This was subcutaneously injected in 5-week-old ICR/JCL mice at 1 week intervals for a total of 1 to 4 administrations. The stomach antibody in the serum gradually increased up to 2(6) until four weeks after the last injection of the stomach antigen. At the same time pyknosis and a decrease in number of the gastric mucosal cells, which ultimately led to the atrophying of gastric mucosa, developed. Thereafter, concomitant with the decrease in serum antibody against mucous cells, regeneration of mucous cells was especially remarkable, but atrophy of the fundic gland continued.

Animals↗
PubMed1977

Morphological and biochemical changes in the gastric mucosa of A/HEJ mice injected with a xenogeneic stomach antigen.

Subcutaneous injection of W/Fu rat stomach antigen emulsified with an equal volume of Freund's complete adjuvant at 1 week interval for a total of 2 administrations induced atrophic gastritis in A/HeJ mice. From the second week after the last injection the parietal cell mass decreased. At the same time, Alcian blue-PAS positive cells and Paneth-like cells appeared. Furthermore, the activity of alkaline phosphatase and disaccharidase of the small intestinal mucosa was biochemically demonstrated in the atrophic glandular stomach.

Alkaline Phosphatase↗
PubMed1977

Induction of rectal carcinoma in mice by local x-irradiation.

The pelvic region of random bred female ICR-JCL mice and CF1 mice was irradiated with various doses of X-rays at 1-week intervals to determine the relationship between the X-ray dose and induction of rectal carcinoma. The incidence of rectal carcinoma in ICR mice was zero after a single dose of 2,000 rad of X-rays, but 31% after a single dose of 3,000 rad, 6% after 2 doses of 1,500 rad, 25% after 3 doses of 1,500 rad, 42% after 2 doses of 2,000 rad, and 95% after 3 doses of 2,000 rad. This cancer developed in 70% of CF1 mice exposed to 2 doses of 2,000 rad. No case of this tumor was observed in the control animals not exposed to X-rays. The development of this tumor was found to depend on the X-ray exposure dose. Local X-irradiation of the pelvic region is one of the effective methods for inducing rectal carcinoma in mice. Rectal cancers induced by X-irradiation were adenocarcinoma of the tubular, papillary, and mucinous type, and frequently showed invasive growth into the deep layers of the rectal wall.

Adenocarcinoma↗
PubMed1977

Serological typing of Pseudomonas aeruginosa--comparison of various antigenic schema.

Serotyping sera for both the agglutination (using IMSUT sera) and slide agglutination (using TIBS sera) were succesfully prepared using Homma's serotype strains. They were proved to be type specific and distinct. The two typing sera (IMSUT and TIBS) were used to determine the correspondence of major O-antigens among the different kinds of serotype schema which are used at present throughout the world. The serotype sera of Lanyi, Liu and Meitert were also used for the same purpose. The relationships among serotypes of the seven schemata were clarified as shown in tables in the text. Cross-reactions were found among several serotypes in each of several serotype schemata was suggested.

Agglutination Tests↗
PubMed1977

Serological typing of Pseudomonas aerugionosa--grouping of serotypes.

Cross absorption and agar gel diffusion tests were performed using Homma and Liu standard strains and their antisera to study the antigenic relationships among the strains showing strong cross-agglutination. The results suggested that Homma 0:3 strain was able to produce a sufficiently high-titered antiserum against Liu 0:7 and 0:8, and that Liu 0:13 was identical to Homma 0:12. In the antisera against Liu 0:13 and 0:14 there existed a strong antibody common to both antigens as well as an antibody specific to each antigen. Furthermore, the presence of strong common antigens was demonstrated among Homma 0:2, 0:7, 0:13 and 0:16, and between Homma 0:15 and 0:17.

Antigens, Bacterial↗