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Biomedical subjects

Y Terada

Publications and source records attributed to Y Terada.

At least 397 records · Page 22Linked to original sources
PubMed1985

Acute interstitial nephritis with bone marrow granulomas and uveitis.

A case of interstitial nephritis with bone marrow granulomas and uveitis was presented. A 53-year-old woman was found to be uremic in the course of rheumatoid arthritis. The renal biopsy revealed acute interstitial nephritis with eosinophilic infiltration. She also had bone marrow granulomas and uveitis. These findings were compatible with those of the syndrome described by Dobrin et al. The etiology and the pathogenesis of this syndrome remain unknown. However, the elevation of the erythrocyte sedimentation rate, raised levels of serum immunoglobulins, presence of circulating immune complexes and decreased T-cell population observed in this patient suggest the involvement of immunological disorders.

Acute Disease↗
PubMed1985

Effect of dilazep on hemoglobin-oxygen affinity in patients with ischemic heart disease.

The effects of orally administered dilazep, an antianginal drug, on the hemoglobin-oxygen affinity were studied in 31 cases with ischemic heart disease. Prior to medication, the mean P50 value was 29.2 +/- 1.65 mmHg. There were no significant differences in the P50 value according to the age of patient or the severity of the coronary arterial disease. Acute effects of dilazep were studied in 29 patients. The 30 min and 60 min post-administration P50 values increased significantly to 30.2 +/- 2.55 mmHg and 30.4 +/- 2.31 mmHg, respectively. Eight patients were administered 300 mg of oral dilazep daily for 4 weeks. Three of 4 in whom exercise tolerance improved showed increases in P50. No changes in various factors which might affect the P50 value, including 2,3-DPG, were found.

2,3-Diphosphoglycerate↗
PubMed1985

Acute but intermittent sticking of a Björk-Shiley mitral valve in closed position.

An acute, intermittent sticking of a Björk-Shiley valve placed in the mitral position is described. It occurred shortly after the valve replacement, but 9 hours later, this 10-year-old female patient recovered from the accident without reoperation. Fluid infusion, left atrial compression, a sharp precordial blow or atrioventricular sequential pacing were effective for unlocking or prevention of the stuck valve. The mechanism was suspected to be impingement of remnant chordae tendinea.

Blood Pressure↗
PubMed1984

Radiograph stress measurement of porcelain fused to metal.

Radiograph stress measurements of precious metals were obtained. The compression stress of approximately -15 kg/mm2 after polishing was reduced by degassing to approximately -8 kg/mm2. In the case of precious metal strips 0.35 mm thick and a porcelain thickness that exceeded approximately 0.5 mm, the surface of the stress measurement was stretched in the longitudinal direction. This result is consistent with the curvature change. The stress behavior at various stages of the firing cycle for porcelain-fused-to-metal crowns was evaluated. The basic data obtained should allow for construction of more satisfactorily fitting restorations.

Dental Alloys↗
PubMed1984

A microangiographic study of renal allograft rejection and the effects of immunosuppression in the rabbit.

Minute renal cortical vascular changes in 14 allografts without treatment, 14 allografts with immuno-suppressive drugs, and 14 control autografts, were studied in rabbits using a quantitative microangiographic technique. The immunosuppressive regimen used was azathioprine 1 mg/kg, cyclophosphamide 1 mg/kg, and methylprednisolone 0.5 mg/kg, daily. The kidney grafts, removed at 2, 4, 6, 8, 10, 12, and 14 days after renal transplantation, were examined histologically and microangiographically . Interstitial mononuclear cell infiltration at two days was observed to almost the same degree in allografts with or without immunosuppressive drugs. In the group without treatment, vasoconstriction of afferent arterioles and interlobular arteries was noted 2 to 4 days after renal transplantation, followed by progressive reduction in glomerular size and number. The vasoconstriction began to recover 6 days after renal transplantation; it is considered to be the first step of the functional disturbance in renal allograft rejection. In the group with immunosuppressive treatment, temporary vasoconstriction of afferent arterioles and interlobular arteries occurred as well. However, subsequent changes at the glomerular level were definitely prevented. These results suggest that immunosuppressive drugs may prevent one of the processes by which infiltrating lymphocytes cause lesions of the glomerular capillary walls.

Angiography↗
PubMed1983

Hyperacute renal allograft rejection in the rabbit. Vasoconstriction demonstrated by microangiography.

A quantitative microangiographic study of renal allografts in rabbits was carried out to determine the pathogenesis of hyperacute rejection. A group of 10 rabbits, presensitized with multiple ear skin grafts from the kidney donor before receiving renal allografts, developed hyperacute rejection. Another 10 rabbits that were not presensitized served as a control group. The kidney grafts, excised at 2, 4, 8, 16 and 24 hr after renal transplantation, were examined histopathologically and microangiographically. In the presensitized group, striking vasoconstriction of afferent arterioles and interlobular arteries occurred within 2 hr after renal transplantation (p less than 0.01), but these vessels gradually recovered to a near-normal state after 24 hr. The number of glomeruli, however, began to decrease at 8 to 16 hours after renal transplantation (p less than 0.01), suggesting that the vasoconstriction produced thrombosis in the glomerular capillaries. These findings suggest that vasoconstriction at the level of afferent arterioles and interlobular arteries is the primary cause of hyperacute rejection.

Angiography↗
PubMed1983

Statine and its derivatives. Conformational studies using nuclear magnetic resonance spectrometry and energy calculations.

The conformations of derivatives of 3(S)-hydroxy-4(s)-amino-6-methylheptanoic acid (statine) and its analogs have been studied by n.m.r. in chloroform and in dimethyl sulfoxide, and by molecular mechanics calculations. The data obtained from these studies indicate that: 1) the coupling constant between NH and C4H is large, suggesting that the dihedral angle (theta) is near 165 degrees or 0 degree; 2) the coupling constant between C4H-C3H is small, indicating a vicinal bond angle of approximately 90 degrees; 3) the hydrogen deuterium exchange rate of statine amide protons is slow; however, the rate is dependent upon the electron withdrawing substituents adjacent to the amide NH's; 4) intramolecular hydrogen bonds involving the NH of the statine amide group do not stabilize conformations of single amino acid derivatives. Based on the n.m.r. results, four possible conformations of Boc-statine-OMe in solution are possible. MM1 calculations indicate one conformation is especially likely.

Amino Acids↗
PubMed1981

[Two cases with the heart murmur originated from aortocoronary bypass: the diagnostic use of dipyridamole (author's transl)].

Two cases with the heart murmurs considered to be caused by aortocoronary (A-C) bypass surgery were reported. Case 1: A systolic and an early and late diastolic murmurs were noted following A-C bypass surgery. The murmurs were located at the second left intercostal space. After methoxamine, the systolic and early diastolic murmurs increases slightly in intensity, while the late diastolic murmur did not change. Amyl nitrite inhalation slightly increased the intensity of the systolic murmur, but did not that of the diastolic murmur. Dipyridamole injection at a rate of 0.142 mg/kg/min resulted in the increase of both systolic and diastolic murmurs. Case 2: A diastolic murmur was noted following the bypass surgery, which was situated over the fourth left intercostal space, 4 cm outside from the left sternal border. Methoxamine injection intensified the murmur. The murmur was not affected by amyl nitrite. After dipyridamole injection, the murmur was slightly intensified. Dipyridamole is known to dilate coronary vessels without affecting appreciably the systemic circulation. In these two cases, the murmur noted following A-C bypass surgery was increased with dipyridamole, suggesting clinical applicability of this drug in ascertaining the bypass flow murmur.

Coronary Artery Bypass↗