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Y Scharf

Publications and source records attributed to Y Scharf.

61 records · Page 4Linked to original sources
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Histocompatibility antigens (HLA) and uveitis.

The studies of histocompatibility (HLA) antigens have contributed to the understanding of the pathogenesis of uveitis. Acute anterior uveitis is associated with rheumatic disorders such as ankylosing spondylitis. HLA-B 27 antigen is present in 98% of these cases. There are genetic and environmental factors influencing the activity of the disease. HLA-B 27 was found to be associated with 43% of cases of acute anterior uveitis without systemic disease. In juvenile chronic polyarthritis with acute anterior uveitis HLA-B 27 helps in differentiating between ankylosing spondylitis and Still's disease. Specific HLA antigens were also found in other forms of uveitis such as Reiter's disease (HLA-B 27), Behcet's syndrome (HLA-B 5), VKH syndrome (HLA-Bw 22J) and ocular histoplasmosis (HLA-B 7). Despite these new findings, there are still many obscure factors and further studies are required to elucidate the pathogenesis of uveitis and to achieve its prevention.

Adult↗
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Azathioprine fever.

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Aged↗
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Pulmonary injury induced by gold salts treatment.

Pulmonary damage is one of the rare complications of gold salts therapy. The reaction is that of drug hypersensitivity. The clinical and radiological features as well as the respiratory function tests are that of an interstitial lung disease. This condition is described in four patients and its main features are discussed in the light of the relevant literature. The importance of an early diagnosis is emphasized. Most of the patients recover after the withdrawal of the drug and during corticosteroid treatment.

Adrenal Cortex Hormones↗