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Biomedical subjects

Y S Fu

Publications and source records attributed to Y S Fu.

At least 163 records · Page 9Linked to original sources
PubMed1975

An ultrastructural study of mixed hepatoblastoma with osteoid elements.

A case of mixed hepatoblastoma with osteoid elements was studied by light and electron microscopy. The ultrastructure of the epithelial elements showed a lack of differentiation and simple cytoplasmic organelles. However, an occasional cytoplasmic crystalloid structure were seen. The ultrastructure of the osteoid foci showed fibroblast-like cells capable of collagen formation, clearly distinguishable from the epithelial elements. These cells had neoplastic characteristics of nuclear pleomorphism and high nucleo-cytoplasmic ratio. These findings support the belief that hepatoblastoma arises from a multipotential blastema capable of both epithelial and mesenchymal differentiation, with the osteoid elements being an intrinsic neoplastic component of the tumor.

Carcinoma, Hepatocellular↗
PubMed1975

Primary malignant melanocytic tumors of the sympathetic ganglia, with an ultrastructural study of one.

Three cases of melanocytic tumors arising in the sympathetic chain were studied. A metastasis from one of them was studied with electron microscopy. Both light and electron microscopy demonstrated the presence in these tumors of true melanogenesis and autophagic activity in melanocytes as well as phagocytosis of mature melanin by associated histiocytes. Review of the embryology, biochemistry and in vitro culture of sympathetic nervous tissue showed a close relationship between it and pigmented cells in other parts of the body which are also derived from neural crest. These findings support the clinical and morphological conclusion that these rare pigmented tumors are true melanocytic tumors originating from the sympathetic chain. The malignant potential of these tumors is emphasized by the fact that the two patients who survived initial surgery later died of metastatic disease.

Ganglia, Autonomic↗
PubMed1975

Biphasic local reaction to a new insulin (U-100).

The phenomenon of localized insulin reaction is described and illustrated by the report of a case. The patient's unusual response consisted of an "early" and a "late" phase to single-peak and single-component insulins. No definite immunologic mechanism was established on the basis of immunologic studies or from histologic examination of skin biopsies.

Adult↗
PubMedDate not supplied

Aneurysmal bone cyst of the cricoid cartilage: an unusual cause of subglottic stenosis.

Aneurysmal bone cysts (ABC) are locally aggressive bony tumors which rarely occur in the head and neck. Only 3 cases have been reported in the larynx previously, 1 involving the cricoid cartilage. A patient is presented who developed subglottic stenosis with airway compromise due to an ABC arising from the cricoid cartilage. The literature on bony tumors of the laryngeal cartilages was reviewed and the clinical and pathologic findings in this case highlighted.

Adult↗
PubMedDate not supplied

Human testicular cultures. II. Sertoli cells.

Two cell types, one epitheloid and the other fibroblast-like, were found in human testicular cultures derived from testes of patients. Ultrastructural studies indicated that, whereas the epitheloid cells were Sertoli cells, the fibroblast-like cells were fibroblasts. The Sertoli cells could maintain growth for a period of more than 4 months. In cultures derived from normal testes, only fibroblasts were observed.

Cell Membrane↗
PubMedDate not supplied

Tricholemmal cysts of the head and neck.

PURPOSE: Tricholemmal cysts, sometimes termed pilomatrixomas, are benign skin neoplasms. This study was undertaken to evaluate the clinical experience with management of pilomatrixomas at a large, referral-based university hospital. PATIENTS AND METHODS: The records of patients treated at the UCLA Medical Center were reviewed retrospectively. Patients treated during the years 1966 to 1991 inclusive were reviewed for details of the clinical course. All pathology slides were confirmed histologically. RESULTS: Pilomatrixoma was confirmed in 53 patients. Of these, 29 patients (55%) had pilomatrixoma isolated to the head and neck region. All were treated with surgical excision. One patient (3%) experienced recurrence due to inadequate initial excision. Subsequent re-excision resulted in a cure. CONCLUSION: Tricholemmal cysts present as solitary, painless, slow-growing cutaneous nodules often resulting in discoloration of the overlying skin. Simple excision cures this benign neoplasm, and recurrences are rare. Fine-needle aspiration biopsy may aid in the diagnostic workup.

Adolescent↗