Search PubMed⌕ Search

Biomedical subjects

Y S Fu

Publications and source records attributed to Y S Fu.

At least 145 records · Page 8Linked to original sources
PubMed1979

Malignant hemangioendothelioma (angiosarcoma) of the salivary gland: an ultrastructural study.

A case of malignant hemangioendothelioma (angiosarcoma) of the submaxillary salivary gland is reported and its microscopic and ultrastructural features are described and compared to previous reports of angiosarcoma arising in other locations. These tumors may often contain areas of solid sheets of cells without vascular characteristics and may be confused with poorly differentiated carcinoma or other sarcomas. The ultrastructural features of angiosarcoma are compared to other poorly differentiated tumors. It is concluded that the ultrastructural features of angiosarcoma are distinctive and aid in the diagnosis of this neoplasm.

Aged↗
PubMed1979

Significance of squamous components in endometrioid carcinoma of the ovary.

Forty-nine cases of ovarian endometrioid carcinoma with squamous foci were reviewed. Of particular interest was the biologic behavior of the neoplasms in relation to the appearance of the epithelium. As previously noted for the analogous uterine endometrial tumors, the ovarian adenosquamous lesions occurred later in life, were more advanced, were associated with less differentiated adenocarcinomatous components, and had a poorer prognosis. The five-year survival rate for patients with adenosquamous endometrioid ovarian carcinoma was 21% in comparison with the 90% survival found in patients with ovarian endometrioid adenocanthoma.

Adenocarcinoma↗
PubMed1979

Malignant peritoneal mesothelioma following radiotherapy for seminoma of the testis.

The difficulties encountered in establishing a diagnosis of a malignant peritoneal mesothelioma are emphasized in a patient who developed the lesion 16 years after radiation therapy for a seminoma of the testis. Historically, histologically, electron microscopically, and by microincineration, there was no evidence of asbestos exposure. We believe that present lesion may be a consequence of prior radiation therapy.

Dysgerminoma↗
PubMed1979

Primary mucinous sweat gland carcinoma of the eyelid simulating metastatic carcinoma.

A 78-year-old man suffered an unusual variant of sweat gland carcinoma of the eyelid. This disorder is seldom recognized, and is frequently confused with inflammation, benign neoplasms, and metastatic carcinomas. On the basis of clinicopathologic and ultrastructural features found by both light and electron microscopy, we diagnosed sweat gland carcinoma of the eyelid. We considered the possibility of metastasis from a primary carcinoma elsewhere in the patient.

Adenocarcinoma, Mucinous↗
PubMed1979

Nuclear DNA and histologic studies of genital lesions in diethylstilbestrol-exposed progeny. II. Intraepithelial glandular abnormalities.

This study has analyzed the nuclear DNA content of intraepithelial glandular lesions in diethylstilbestrol (DES)-exposed offspring. The endocervical cells and endometrial-tubal cells present in the vaginal adenosis and pericervical collars had a euploid distribution. However, greater proliferative activity was found among the endometrial-tubal cells. In the cells of vaginal adenosis of a postpartum woman without a confirmed history of maternal exposure to DES, a polyploid pattern was found, indicating that endometrial-tubal cells underwent hyperplastic changes under the influence of hormonal stimulation. In an atypical adenosis derived from endometrial-tubal cells, an aneuploid pattern was found. Based on these findings, it is suggested that endometrial-tubal cells have a greater proliferative potential than endocervical cells.

Adult↗
PubMed1978

Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx. A clinicopathologic study. IX. Plasmacytomas.

Plasmacytomas occasionally may arise in extraosseous sites, of which the upper respiratory tract is the most common. In our series of 256 nonepithelial tumors involving the nasal cavity, paranasal sinuses and nasopharynx, 10 (4%) were apparently primary extramedullary plasmacytomas. Of our patients with adequate follow-up information, four died of disseminated disease 2, 4, 5 and 6 years after the initial diagnosis. One was alive 6 years after diagnosis with locally persistent tumor. Another was living without recurrence 12 years later. Based on our findings and on the cases reported in the literature, extramedullary plasmacytomas arising in the head and neck area may evolve into one of several different patterns. 1) Some patients have localized disease which is apparently controlled (by surgery, radiotherapy or both) and which never recurs locally or becomes disseminated. 2) In some cases, the tumor recurs locally and is controlled by further therapy. 3) Other patients have a locally persistent and aggressive lesion which cannot be eradicated and which eventually leads to the patient's death by uncontrolled local growth. 4) Still other patients eventually develop evidence of plasma cell neoplasms elsewhere in the body and/or multiple myeloma.

Adult↗
PubMed1977

Non-epithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinico-pathologic study. VII. Myxomas.

In a study of non-epithelial tumors involving the nasal cavity, paranasal sinuses and nasopharynx, 256 lesions, 156 benign and 100 malignant, were identified. Of these, six were classified as myxoma. Myxomas of facial bones, neoplasms of uncertain histogenesis, infiltrate adjacent tissues and if not completely excised will recur locally. In this series, three patients at one time were treated with limited local excisions. Tumor persisted or recurred in all three. Five patients were treated with en bloc resection (following recurrences in two patients). None of these patients subsequently developed recurrent tumor. We believe that myxomas should be widely resected to prevent recurrence. The extent of the surgical resection should depend on the size, extent and location of the lesion.

Adolescent↗
PubMed1977

Non-epithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinicopathologyic study. VIII. Adipose tissue tumors (lipoma and liposarcoma).

In a study of 256 non-epithelial neoplasms involving the nasal cavity, paranasal sinuses and nasopharynx, only two lesions were classified as adipose tissue tumors (one lipoma and one liposarcoma). The lipoma was found incidentally when tissue removed from the maxillary sinus was studied histologically, the patient having been treated with a Caldwell-Luc procedure for maxillary sinusitis. The liposarcoma produced a large mass involving the nasal cavity, maxillary sinus, ethmoid area, hard palate and maxillary, temporal and sphenoid bones. The tumor extended into the cranial cavity and eventually led to the patient's death. The problems involved in histologically differentiating liposarcomas from other lesions are discussed. Even though adipose tissue tumors are among the most common soft tissue neoplasms, these lesions rarely occur in the nasal cavity, paranasal sinuses and nasopharynx.

Adult↗
PubMed1976

Nonepithelial tumors of the nasal cavity paranasal sinuses, and nasopharynx: a clinicopathologic study. V. Skeletal muscle tumors (rhabdomyoma and rhabdomyosarcoma).

In a study of nonepithelial tumors involving the nasal cavity, paranasal sinuses, and nasopharynx, 19 lesions (three rhabdomyomas, 16 rhabdomyosarcomas) showed skeletal muscle differentiation. The clinical findings associated with these neoplasms are reviewed, the histologic features are illustrated, results of treatment are presented, and clinicopathologic correlations are discussed. The rhabdomyomas grew as localized masses in the nasopharynx, were excised locally, and behaved clinically like benign tumors. The rhabdomyosarcomas were found predominantly in children and were associated with a poor prognosis; most of the patients died within 2 years following diagnosis.

Adolescent↗
PubMed1976

Nonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study. VI. Fibrous tissue tumors (fibroma, fibromatosis, fibrosarcoma).

In a study of 256 nonepithelial neoplasms involving the nasal cavity, paranasal sinuses, and nasopharynx, 23 lesions were classified as fibrous tissue tumors, including four cases of "fibroma", six of fibromatosis, and thirteen of fibrosarcoma. The clinical findings associated with these lesions are described, their histologic features illustrated, results of therapy presented and clinicopathologic correlations made. The "fibromas" presented a small localized nodules. None recurred after local excision. Fibromatosis, a locally aggressive tumor, does not metastasize, but may cause considerable morbidity or even death due to local infiltration which may be difficult to control surgically. Fibrosarcoma may cause death either by local infiltration or by metastasis, but has a better prognosis than most other sarcomas of this region. We recommend that a large en block resection be performed initially for fibromatosis and fibrosarcoma growing in this area, after the diagnosis has been made by biopsy. In this series, including patients who had more than one operation, recurrent tumor was seen following 10 of 12 limited local excisions performed for fibromatosis and fibrosarcoma, but in only one of 13 patients after a large bloc resection. The problems involved in histologically differentiating fibrous tissue tumors from other lesions are discussed. A patient with the rare syndrome of multicentric fibromatosis with spontaneous regression of lesions is presented.

Adult↗
PubMed1976

Pulmonary blastoma: A light and electron microscopic study.

A case of pulmonary blastoma studied with the electron microscope showed two distinct cell types, i.e., epithelial and mesenchymal elements. The former demonstrates the differentiation toward ciliated bronchial cells, and the latter, cartilage. In view of these findings, coupled with the current understanding of pulmonary morphogenesis, the pulmonary blastoma is more likely to be a carcinosarcoma than a true blastoma. However, the separation between pulmonary blastoma as usually employed and the so-called pulmonary carcinosarcoma seems to be desirable because of different clinicopathologic features.

Adult↗
PubMed1976

Organ culture of craniopharyngioma and its cellular effects induced by colloidal chromic phosphate.

Since a marked clinical improvement has been reported following chromic phosphate treatment in recurrent craniopharyngioma, we have attempted to study the in vitro cellular changes of two craniopharyngiomas maintained in organ culture system and subsequently treated with colloidal chronic phosphate. When incubated for 24 and 48 hours respectively, at a concentration of 10 muCi/ml. of colloidal 32P, only vacuolar degeneration and hyperchromasia of the tumor cells have been observed. When incubated with 50 muCi/ml. for 24 hours, further cellular degeneration and focal necrosis begin to appear. Up to 48 hours after 50 muCi/ml. obvious necrosis and extensive degeneration become apparent. Autoradiography confirms the fact that radioactive material is absorbed by the tumor cells. Brain tumors when maintained in an organ culture system may serve as a useful model for the evaluation of the effects of various chemotherapeutic and radiotherapeutic agents in vitro.

Adult↗
PubMed1975

Tissue culture study of a sacrococcygeal chordoma with further ultrastructural study.

This report concerns an electron microscopic study of a sacrococcygeal chordoma and its in vitro cultured cells. In vitro, the cells that proliferated in the early phase were predominantly non-vacuolated stellate cells, which were later transformed into vacuolated cells. This suggests that various cell types seen in vivo represent variants of the same cell type at different stages of differentiation and cellular activity. The in vitro tumor cells also show the origin of their vacuoles from both rough endoplasmic reticulum and Golgi membranes. The finding of amorphous and granular material and collagen fibrils in the extracellular spaces of cultured cells seems to suggest that chordoma cells have certain synthetic and secretory activity.

Cell Differentiation↗
PubMed1975

Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): general considerations and electron microscopic and tissue culture studies.

Correlated light and electron microscopic study of four fibrous histiocytomas of proven malignancy has confirmed the presence of histiocyte-like and fibroblast-like cells in this tumor. In addition, an undifferentiated cell type, giant cells, xanthomatous cells, and rare cells with morphological characteristics intermediate between those of histiocytes and fibroblasts were seen. "Nuclear body" type inclusions were commonly present in both principal cell types in all four cases, as were the somewhat less common cytoplasmic inclusion bodies. Electron microscopic study of a tissue culture of one of these tumors demonstrated only fibroblast-like, histiocyte-like, and xanthomatous cells. The possibility is suggested that both principal cell types in this tumor may derive from the same undifferentiated stem cell.

Adult↗
PubMed1975

Nonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: a clinicopathologic study. IV. Smooth muscle tumors (leiomyoma, leiomyosarcoma)

In a review of nonepithelial tumors involving the nasal cavity, paranasal sinuses, and nasopharynx, 256 lesions, 156 benign and 100 malignant, were identified. Of these, 8 were smooth muscle neoplasms, 2 leiomyomas, and 6 leiomyosarcomas. The clinical findings associated with these smooth muscle tumors are described, their histologic features illustrated, results of therapy presented, and clinicopathologic correlations made. The leiomyomas were small lesions found incidentally within polypectomy specimens, and were successfully treated by polypectomy. Leiomyosarcomas could not be eradicated easily by surgery, recurred frequently, did not respond well to radiotherapy, and carried a poor prognosis.

Adolescent↗