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Biomedical subjects

Y Oono

Publications and source records attributed to Y Oono.

48 records · Page 3Linked to original sources
PubMed1987

Carcinoembryonic antigen and lectin binding in the bile canalicular structures of hepatocellular carcinoma.

Bile canalicular structures of 32 hepatocellular carcinomas and 36 cirrhotic livers were investigated by light microscopy using immunohistochemistry for carcinoembryonic antigen (CEA) and lectin histochemistry. CEA positive bile canalicular structures were found in 17 out of 32(53%) hepatocellular carcinomas and in 33 of 36(92%) cirrhotic livers. Among the 10 lectins examined, about 40% of the CEA positive bile canalicular structures of hepatocellular carcinomas showed positive binding of MPA, DBA, WGA, RCA-I or UEA-I, whereas only MPA or RCA-I bound to the CEA positive bile canalicular structures of cirrhotic liver, in about 20% of cases. It has been shown that the CEA positive bile canalicular structures of hepatocellular carcinomas are heterogeneous and differ from those of cirrhotic liver in lectin histochemistry.

Bile Canaliculi↗
PubMed1985

Plasma concentrations of fibrinopeptide A and fibrinopeptide B beta 15-42 in glomerulonephritis and the nephrotic syndrome.

Plasma fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 concentrations were determined by radioimmunoassay in 46 patients with glomerulonephritis and the nephrotic syndrome. An increase in plasma FPA and B beta 15-42 levels was noted in these patients; this increase was marked in the nephrotic patients. There was a positive correlation in these patients between plasma FPA and B beta 15-42 levels. The B beta 15-42/FPA ratio was significantly higher in nonnephrotic patients compared with controls. Intravascular coagulation with subsequent fibrinolysis to regulate fibrin formation may occur in patients. A positive correlation was found between plasma B beta 15-42 level and serum urea nitrogen or serum creatinine concentration, suggesting that plasma B beta 15-42 level is influenced not only by plasmin action, but also by renal dysfunction.

Adolescent↗
PubMed1982

[Relationship between circulating androgens and ovarian hyperstimulation syndrome in anovulatory patients treated with hMG-hCG].

In order to evaluate relationship between circulating androgens levels and development of ovarian hyperstimulation syndrome (OHS) in anovulatory patients treated sequentially with hMG and hCG, serum concentrations of androstenedione (A), testosterone (T) as well as estradiol (Ed) were measured serially in a total of 17 anovulatory patients including 9 who did not develop OHS and 8 who developed mild or moderate OHS. Increase of Ed levels during the period of hMG treatment varied remarkably in individual patients with OHS ranging from 7.2 to 190.1 times as much the pretreatment value. On the other hand, increase of A levels during the hMG treatment was recorded in the range from 2.0 to 3.2 times as much the pretreatment value in 4 patients with mild OHS, and from 1.5 to 5.9 in 4 patients with moderate OHS. However, the ratio of A increase remained within 1.4 times in patients without OHS. A transient increase of circulating T was observed in 2 days after commencement of hCG treatment, ranging between 1.4 and 3.2 times in patients without OHS, between 1.8 and 2.4 times in patients with mild OHS and between 3.8 and 6.8 times in patients with moderate OHS. It is concluded that serial measurements of A and T during the course of hMG and hCG treatments respectively appear to be an additional index other than Ed to predict development of OHS.

Androgens↗