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Biomedical subjects

Y Nishibe

Publications and source records attributed to Y Nishibe.

At least 55 records · Page 3Linked to original sources
PubMed1978

Effects of phosphonoacetic acid on subacute myeloopticoneuropathy virus in vitro and in vivo.

The effect of phosphonoacetic acid (PAA) in vitro and in vivo on subacute myeloopticoneuropathy (SMON) virus isolated from the spinal fluid of SMON patients was studied. PAA inhibited multiplication of SMON virus in cultures, but it did not show a direct effect on the virus. The drug did not influence the disease when the medication was started from 10 days after infection of suckling mice. However, the drug did elicit a delay in the incubation period.

Animals↗
PubMed1976

Subacute myelo-optico-neuropathy (SMON) following pneumonitis. Serologic confirmation three and a half years after death.

A case of fulminant subacute myelooptico-neuropathy that occurred in a native American women following pneumonitis instead of the usual gastrointestinal dysfunction is reported. After the acute stage, which left the patient paraplegic and partially blind, she suffered an exacerbation which resulted in her death 11 months after the onset of illness. Autopsy disclosed symmetric optic and spinal demyelination. Neutralizing antibody titer against subacute, myelo-optico-neuropathy virus was determined on postmortem serum 3 1/2 years after death and found significantly elevated.

Abdomen↗
PubMed1976

Animal experiments on thiamine avitaminosis and cerebral function.

Before industrial production of thiamine becam possible, among many beriberi patients some showed symptoms of encephalopathy, the cerebral form of the disease. In this animal experiment, thiamine-deficient rats showed failure or blocking of the operant behavior in the maze box, pole climbing box and shuttle box, indicating orientation disturbance and defective memory. This Wernicke's syndrome-like sign dramatically disappeared by treatment with thiamine. Potentiated narcosis with thiopental or alcohol induced in thiamine-deficient rats and mice was readily reversible by thiamine administration. These phenomena are associated with thiamine content of the brain and are found long before histopathological changes in the brain of deficient animals. It is easily surmised that thiamine deficiency in the brain may block the brain metabolism and subsequently cause changes in any chemical substances in the brain, refracting on biophysical phenomenon, such as EEG. However, in the present study, generally speaking, no meaningful results concerning these points were obtained.

Animals↗
PubMed1976

Induction of SMON-type virus form avian infectious laryngotracheitis virus.

SMON-type virus which shows different host range was induced from ILT virus under unsuitable culture conditions for the growth of the parental ILT virus, such as cultivation in CAM of 12-day-old eggs or cultivation in CHK cells at 32 degrees. Furthermore, it was induced from ILT virus by mutagenesis by either BrdU or NG in CHK cell cultures.

Age Factors↗