[Human science. Life science. 2. Defense mechanism of the body].
Explore the source record for details and available documents.
Antibody Formation↗
Biomedical subjects
Y Nagano
Publications and source records attributed to Y Nagano.
Endocrinologic regulation of carbohydrate metabolism. Amyotrophic lateral sclerosis and Parkinsonism-dementia on Guam.
Studies of the endocrinologic control of carbohydrate metabolism were conducted in Guamanians with parkinsonism-dementia (PD) or amyotrophic lateral sclerosis (ALS) and in Guamanian control patients who had various other neuromuscular disorders. Intravenously infused arginine tended to produce a more prolonged elevation in serum glucose levels in PD and ALS patients than in control subjects. On the other hand, the serum insulin response to arginine was significantly less in both PD and ALS patients than in controls. Arginine stimulated the release of growth hormone to a similar degree in all three patient groups. These observations support and extend previous reports of endocrinologic abnormalities in parkinsonism and ALS and might suggest that a defect in pancreatic islet cell function attends these disorders.
Adult↗
[Effects of the virus-inhibiting factor or interferon on the in vitro multiplication of mouse tumor cells].
1) The in vitro effect of virus-inhibiting factor (IF) or interferon on Ehrlich ascites tumor and sarcoma 180 was found to be cytostatic, but not cytocidal. 2) Mouse peritoneal macrophages or splenic lymphoid cells, in the presence of IF, did not affect multiplication of the tumor cells examined.
Animals↗
[Role of host cells in suppression of the in vivo multiplication of Ehrlich's ascitic cancer cells by the virus-inhibiting factor or interferon].
Neither activation nor depression of murine peritoneal macrophages or lymphoid cells modified the suppressive effect of the virus-inhibiting factor or interferon on the multiplication of Ehrlich's ascitic cancer cells in mice.
Animals↗
[Effect of the virus-inhibiting factor or interferon on the division and differentiation of murine leukemic cells].
Myeloblasts of a clone originating from a spontaneous myeloid leukemia in mice were induced to form macrophages by the virus-inhibiting factor or interferon or its inducers such as Newcastle disease virus and double-stranded RNA.
Animals↗
[Different types of virus inhibitory factors in interferon produced by different organs].
Fragments of organs from mice inoculated with Newcastle disease virus were incubated at 30 degrees C. Lungs and liver produced thermolabile virus-inhibiting factor (IF) or interferon at earlier stages. The spleen, lymph nodes and thymus produced thermolabile IF at earlier stages and thermostable IF at later stages.
Animals↗
[Hyper- and hypo-reactivity in mice with regard to the induction of virus inhibitory factor or interferon].
1. IF induction in mice with Newcastle disease virus produced hyperreactivity on subsequent induction with certain doses of poly I:C. 2. Laparotomy or intraperitoneal injection with air caused temporary hyporeactivity of spleen and lungs on IF induction with endotoxin. Laparotomy in splenectomised mice did not affect IF formation in lungs.
Air↗
[Effect of urethane on the granulopexic activity of the reticuloendothelial system and the production of virus inhibiting factor or interferon].
Urethane (ethyl carbamate) did not affect the rate of the clearance of carbon from the blood in splenectomized mice, while this compound slowed down the carbon clearance in intact mice. Production of virus-inhibiting factor (IF) or interferon, especially early IF induced by virus was impaired by urethane in splenctomized mice as well as intact ones. The role of reticulo-endothelial system in IF formation was discussed.
Animals↗
[Abnormal carbohydrate metabolism in amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam (author's transl)].
Explore the source record for details and available documents.
Amyotrophic Lateral Sclerosis↗
Dermatoglyphics in congenital rubella syndrome with congenital heart disease.
Explore the source record for details and available documents.
Child↗
Endotoxin induction of interferon.
Explore the source record for details and available documents.
Acids↗
[Amyotrophic lateral sclerosis on Guam. Part 1 (author's transl)].
Explore the source record for details and available documents.
Adult↗
[Amyotrophic lateral sclerosis on Guam Part 2 (author's transl)].
Explore the source record for details and available documents.
Adult↗
Effect of activation of the reticuloendothelial system on formation of virus-inhibiting factor or interferon.
Explore the source record for details and available documents.
Animals↗
Role of spleen cells in formation of virus-inhibiting factor or interferon.
Explore the source record for details and available documents.
Adhesiveness↗
Suppression of intracellular multiplication of Mycobacterium tuberculosis by virus-inhibiting factor or interferon.
Explore the source record for details and available documents.
Animals↗
Virus-inhibiting factor or interferon activity on heterologous animal cells.
Explore the source record for details and available documents.
Animals↗
[Adsorption of lymphocytes by cells infected by vaccinia virus].
The interaction of chicken lymphocytes with vaccinia-infected cells was examined HEp-2 cells infected with the virus adsorbed chicken lymphocytes. The phenomenon was inhibited by anti-vaccinia serum. Lymphocytes prepared from a chicken possessing red blood cells insensible to the hemagglutinin of vaccinia virus were also adsorbed. Lymphocytes were adsorbed in similar degree at 37 degrees C and at room temperature.
Animals↗