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Biomedical subjects

Y Murai

Publications and source records attributed to Y Murai.

At least 217 records · Page 12Linked to original sources

Beriberi neuropathy. Morphometric study of sural nerve.

Seven biopsied sural nerves from patients with beriberi were morphometrically evaluated. In teased fiber analysis the mean frequency of myelinated fibers showing axonal degeneration and segmental demyelination was 37.5 and 5.3%, respectively. In two cases with frequency of segmental demyelination higher than 5%, segmental demyelination was shown by statistical criteria to have occurred on certain fibers in a clustered fashion. Therefore, the segmental demyelination in beriberi may be secondary to axonal degeneration. Electromyographic findings and slow improvement of muscle weakness were compatible with axonal degeneration of motor fibers. Determinations of fiber densities revealed preferential decrease of the density of large myelinated fibers with the preservation of the density of small myelinated and unmyelinated fibers. The preferential nerve fiber involvement in beriberi was not associated with pain in the lower limbs and this fact is contrary to the expectation of the proponents of the gate control theory.

Adolescent↗

Conglutinin-like factors in human saliva--relation to other salivary aggregating factors--.

This study was conducted to examine the relation between conglutinin-like factors and other bacterial aggregating factors in human saliva. Human and guinea pig complement intermediate cells (EAC4b,3b) were prepared by using and anticomplementary agent K-76 COONa. Conglutinin-like factors and agglutinins for sensitized sheep erythrocytes in parotid and whole saliva from seven subjects were examined. Whole saliva from the subjects with a periodontal disease showed a lower activity than that from the subjects with a clinically normal gingiva. It seems, therefore, that some strum component from the gingival crevice inhibit the aggregation of sensitized sheep erthrocytes by saliva as in the case of the conglutination of EAC4b, 3b cells. Conglutinin-like factors appeard over a wide region including both the void volume and the secretory IgA region in gel filtration of human whole saliva on Sepharose 4B. The void volume fractions contained a high conglutinin-like factor activity but no Iga activity. These data suggest that conglutinin-like factors are not polymers of IgA but complexes of glycoproteins or those on which IgA is bound furthermore.

Agglutination↗

Deep tendon reflex in Eaton-Lambert syndrome.

The mechanism of absent or decreased deep tendon reflex in Eaton-Lambert syndrome was studied. There was no evidence suggestive of the presence of a neuropathy. On the other hand, a brief (about 10 seconds) maximal voluntary contraction made the absent deep tendon reflexes elicitable, which suggests that the block of neuromuscular transmission in Eaton-Lambert syndrome is responsible for the absent or decreased deep tendon reflex. Such enhancement of the decreased deep tendon reflex in Eaton-Lambert syndrome might be helpful in differentiating neuropathy and Eaton-Lambert syndrome.

Bronchial Neoplasms↗