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Biomedical subjects

Y Minagawa

Publications and source records attributed to Y Minagawa.

At least 73 records · Page 4Linked to original sources
PubMed1987

Severe fetal supraventricular bradyarrhythmia without fetal hypoxia.

Cardiac anatomy and rhythm were evaluated in a fetus at 39 weeks' gestation in a pregnant woman referred because of severe fetal bradycardia with a persistent fetal heart rate of 50-60 beats per minute. M-mode echocardiograms revealed supraventricular bradyarrhythmia. Umbilical cord blood analysis did not, however, reveal fetal hypoxia. Diagnostic methods of fetal bradyarrhythmia are discussed, and the importance of differentiating bradyarrhythmia from bradycardia due to fetal hypoxia is emphasized.

Adult↗
PubMed1986

Further characterization of a human sperm coating antigen (gp12).

In our previous paper, we identified a novel sperm-coating antigen with molecular weight of approximately 12,000 daltons that is highly specific to sperm, seminal plasma, and milk from the plasma membrane fraction of human spermatozoa by using rabbit antiseminal plasma antiserum. In the present study, this 12,000-daltons component, termed gp12, has been investigated for its tissue distribution and antigenic stability. The largest amounts of the antigen are found in seminal plasma, although individual variation is rather high. In seminal plasma, the gp12 molecule presents in a large form with a molecular weight of approximately 50,000 daltons. Its antigenicity is stable when treated with acid, alkali, heat, and various protein denaturants.

Antigens, Surface↗
PubMed1986

[Study on utero-placental circulation by pulsed-Doppler technique--blood flowmetric study in placental pores].

The flow velocity waveform (FVW) was obtained by means of the pulsed-Doppler technique from the placental pores visualized as anechoic areas on the ultrasonic tomogram in 36 cases of singletons and 7 cases of multiple pregnancies. Utilised parameters for analysis of the sonogram were resistance index and systolic to diastolic ratio of flow velocity (S/D ratio) which were independent of the angle between the ultrasonic beam and the direction of blood flow. Diagnostic apparatus were composed of real-time sector scanner and Doppler unit with FFT analyser by which sampling points were selectable within 15 cm of depth. The FVW from the placental pores was recorded as the toward flow in the case of posteriorly attached placentas and was similar to the one from the arcuate arteries which has poor pulsatility and high diastolic flow in the normal pregnancies. There was a tendency for the increase in the gestosis index (GI) to be related to that of RI. Multiple pregnancies revealed lower RI than singletons in the same GI group. There was reverse correlation between mean birth weight and mean RI in the cases who received pulsed-Doppler examination within 2 weeks prior to delivery. The RI and S/D ratio showed a high correlation in the each cases (r = 0.99).

Adult↗
PubMed1986

[Clinical studies on the effect of imipenem/cilastatin sodium on infections in obstetrics and gynecology. Tissue concentrations and clinical effects].

Tissue transfer and clinical effects of imipenem/cilastatin sodium (MK-0787/MK-0791), a new carbapenem antibiotic, were studied and the following results were obtained. Penetrations of MK-0787 into uterine arterial blood and into pelvic dead space exudate were good. When MK-0787/MK-0791 was administered at a dose of 500 mg/500 mg by a 30-minute intravenous drip infusion, the peak level of MK-0787 in uterine arterial blood was 22.2 micrograms/ml, 30 minutes after the completion of the drip infusion. The peak level of MK-0787 in pelvic dead space exudate was 12.9 micrograms/ml at 2 hours and it dropped to 2.6 micrograms/ml at 6 hours. MK-0791 levels were similar to those of MK-0787. Penetrations of MK-0787 into tissues were also good. When MK-0787/MK-0791 was administered at a dose of 500 mg/500 mg by a 30-minute intravenous drip infusion, the level of MK-0787 was 2.2 +/- 1.1 micrograms/g in the oviduct, 2.7 +/- 2.1 micrograms/g in the ovary, 2.5 +/- 1.2 micrograms/g in the endometrium, 3.0 +/- 1.6 micrograms/g in the myometrium, 3.1 +/- 1.9 micrograms/g in the cervix uteri and 3.8 +/- 2.0 micrograms/g in the portio vaginalis at 1 hour after administration. These levels were reduced to halves, respectively, in approximately 2 hours. Four patients with intrauterine infections and 2 with vaginal stump infections were treated with MK-0787/MK-0791 at a daily dose of 1 g/1 g (500 mg/500 mg X 2). Good clinical and bacteriological responses were observed in 5 patients and causative organisms were eradicated in 2 patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

[Studies on individual fetal weight estimation by ultrasonography in multiple pregnancies].

Fetal weight estimation was tried in each fetus in 16 cases of twins and 2 cases of triplets using the formula derived from the regression analysis of fetal biometric data and actual neonatal weights in 26 cases of singleton pregnancies. The fetal biometric data used were biparietal diameter (BPD), abdominal antero-posterior diameter (APD), abdominal transverse diameter (TD), abdominal circumference (AC) and fetal femur length (FFL). The correlation between the estimated and actual weight was significant (r = 0.926) and the estimation error in neonates smaller than 2,500 g was less than 10% of the birth weight. Estimated weight differences in 16 pairs of twin pregnancies correlated well with the actual weight differences (r = 0.678). A sensitivity of 70% and specificity of 100% were revealed in the diagnosis of IUGR using the estimation formula and the intrauterine fetal growth curve. These results showed how the estimation formula derived from ultrasonically measured fetal biometric parameters, can be applied clinically but two kinds of formula with or without BPD are necessary for fetal weight estimation in multiple pregnancies as only 53% of BPD were available for fetal weight estimation.

Anthropometry↗
PubMed1986

[Evaluation of fetal development and well-being with the ultrasonic Doppler fetal actocardiograph].

Fetal development and well-being were investigated during pregnancy with respect to the relation between fetal movement (FM) and fetal heart rate (FHR) in 192 normal and 43 high-risk fetuses in the antepartum period utilizing ultrasonic Doppler fetal actocardiograph that enabled the simultaneous and continuous recording of FM and FHR by single ultrasonic probe. The analysis of simultaneously obtained records of FHR and the movements of fetal trunk and legs revealed that gross fetal trunk movement was mainly related with FHR acceleration. The number of FM signal bursts, which was accompanied by fetal trunk rotating movements, showed a peak at 30-31 weeks of gestation and decreased in the other stage of pregnancy. The synchronization rate of FM signal bursts to transient FHR rises increased with gestational age, and the amplitude and inclination of the rise accompanied by bursts increased linear from the 24th to the 38th week of gestation. Fetuses of high-risk pregnancy produced on antepartum actocardiogram with low FM and FHR values. The changes were particularly remarkable in the cases of intrauterine growth retardation and/or gestosis.

Embryonic and Fetal Development↗
PubMed1986

[Pathological and endocrinological study of epithelial ovarian tumors in post-menopausal women].

We have studied 37 cases of ovarian epithelial tumors in post-menopausal women, histopathologically and endocrinologically. The normal values for androstenedione, estrone, estradiol and progesterone in healthy post-menopausal women were less than 83 ng/dl, 75 pg/ml, 30 pg/ml and 0.6 ng/ml, respectively. The numbers of cases, the serum values for which were higher than normal, were 9 of 16 (androstenedione), 9 of 16 (estrone), 22 of 29 (estradiol) and 14 of 20 (progesterone). The serum levels of these 4 sex hormones in cases with ovarian stromal condensation (stromal cell hyperplasia) were higher than normal in 8 of 11 (androstenedione), 8 of 11 (estrone), 17 of 19 (estradiol) and 9 of 12 (progesterone), whereas those in cases with no stromal condensation were elevated in 1 of 5, 1 of 5, 5 of 8 and 5 of 7, respectively. After complete removal of the tumors, these elevated sex hormone levels dropped to normal. After the dexamethasone suppression test, the suppression rates for cortisol, 17-OHCS and 17-KS were 4 times as great as those of DHEA-S (dehydroepiandrosterone-sulfate), estrone, estradiol and progesterone. 17 beta-estradiol was localized in hyperplastic ovarian stromal cells in all cases with stromal condensation. We concluded that many of the ovarian epithelial tumors produce these sex hormones and that hyperplastic stromal cells are the source an increased amount of serum estradiol.

Adenocarcinoma↗
PubMed1985

A human sperm coating antigen isolated from sperm cell membrane.

A human sperm cell membrane antigen that is highly specific to sperm and seminal plasma was isolated from plasma membrane fraction of spermatozoa using rabbit antiserum against human seminal plasma. In addition to the high specificity to sperm and seminal plasma, the isolated antigen showed the following characteristics: (1) It is a glycoprotein of approximately 12,000 daltons that has an affinity to lentil lectin; (2) it is distributed in human milk other than in sperm and seminal plasma, but is not found in any other organs and tissues including testis; (3) seminal plasma contains the largest amount of the antigen activity, 60-fold greater than spermatozoa and 900-fold greater than milk, suggesting that this antigen could be a sperm-coating seminal plasma antigen.

Antigens↗