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Biomedical subjects

Y Mashima

Publications and source records attributed to Y Mashima.

At least 181 records · Page 10Linked to original sources
PubMed1983

[Effect of fat emulsion (intralipid) on essential fatty acid deficiency during total parenteral nutrition in pediatric patients. Part 2. Clinical study].

Thirteen infants who received total parenteral nutrition (TPN) in four different ways were studied in order to determine the essential fatty acid (EFA) requirement in pediatric TPN. The serum fatty acid composition of the infants who received fat-free TPN showed EFA deficiency within one week. This deficiency was cured by administering fat emulsion which accounted for 4% of the total caloric content of the infusate. Fat emulsion which accounted for 2% of the total calories neither improved nor prevented EFA deficiency. This means that intravenous fat emulsion, Intralipid, which accounted for 2% of the total calories as linoleic acid, still satisfies the EFA requirement.

Arachidonic Acids↗
PubMed1976

The effect of fat emulsion (Intralipid) on essential fatty acid deficiency in infants receiving intravenous alimentation.

Thirteen infants who received IVA in four different ways were studied. The serum fatty acid composition of the infants who received fat-free IVA showed EFA deficiency within 1 wk. This deficiency was cured by administering fat emulsion which accounted for 4% of the total caloric content of the infusate. Fat emulsion which accounted for 2% of the total calories neither improved nor prevented EFA deficiency. This means that intravenous fat emulsion, Intralipid, which accounted for 2% of the total calories as linoleic acid, still satisfies the essential fatty acid requirement.

Child, Preschool↗
PubMed1975

The effect of fat emulsion on essential fatty acid deficiency during intravenous hyperalimentation in pediatric patients.

A series of experiments on puppies and two newborn infants indicates that Intralipid which covered only 4% of the total caloreis, prevented or improved essential fatty acid deficiency in puppies and infants on hyperalimentation. This means that the intravenous fat emulsion, which covers about 2% of the total caloric intake with linoleic acid, still satisfies the essential fatty acid requirement, since half of the fatty acid composition of Intralipid is linoleate.

Animals↗
PubMedDate not supplied

Effect of calorie overload on puppy livers during parenteral nutrition.

UNLABELLED: To investigate the possible cause of hepatomegaly during TPN, chemical analyses were performed on the livers of puppies weighing around 2 kg, supported by TPN for 1 wk, under 3 different calorie levels: Group I (5) under 135 cal/kg as standard calorie, Group 2 (6) fed ad libitum with dog food, Group 3 (5) received TPN for 7 days at 135 cal/kg/day, Group 4 (5) TPN at 200 cal/kg/day, and Group 5 (5) at 270 cal/kg/day. The livers of puppies starved for 24 hrs and orally fed were studied as controls. RESULTS: 1) remarkable hepatomegaly with anemic discoloration and rise in sGOT, sGPT, and Alpase were the constant findings in G-2 and G-3.2). Liver weight in starved, fed G-1, G-2, and G-3 were 66.0 +/- 7.5g, 82.8 +/- 18.5g, 108.32 +/- 21.36g and 247.06 +/- 17.83g, respectively. 3) Glycogen and water contents in the livers were: in starved 0.17 +/- 0.07g and 48.75 +/- 5.75 ml, in fed 5.37 +/- 3.24g and 60.72 +/- 13.71 ml, in G-1 10.35 +/- 4.87g and 79.4 +/- 16.84 ml, in G-2 45.05 +/- 7.41G and 173.31 +/- 21.26 ml, and in G-3 45.19 +/- 20.47g and 178.45 +/- 56.63 ml, indicating that the weight increment can be explained by the increase in glycogen and water deposit in the liver. 4) Triglyceride in livers in G-2 and G-3 increased by 2 times the controls. These results suggest the possibility of the occurrence of hepatomegaly with glycogen and water accumulation accompanying the rise in serum enzyme by calorie overload in clinical TPN.

Animals↗
PubMedDate not supplied

Changes in phosphorus distribution during total parenteral nutrition.

To investigate the mechanism of hypophosphatemia during total parenteral nutrition (TPN), changes in phosphate (P) contents in the liver and muscle of rats supported by TPN for 2 days at 270 cal/g were studied in 39 Sprague Dawley rats (200 g body weight), divided into 5 groups as follows: G-I: starved for 24 hr (n = 7); G-II: TPN (5 mEq P/1000 cal) after 24 hr starvation (n = 7); G-III: starved for 4 days (n = 7); G-IV: TPN (5 mEq P/1000 cal) after 4 days starvation (n = 9); G-V: TPN (35 mEq P/1000 cal) after 4 days starvation (n = 9). P contents of the tissues were measured colorimetrically. Results indicated that muscle P content decreased in the depleted rat supported by TPN with low P intake, while an increase in P content in the liver was a constant finding in each TPN group. Increase in P intake tended to preserve the P content in the muscle. These findings suggest that the changes in P distribution in major body tissues must be considered in addition to the changes in the serum inorganic P levels to evaluate an adequate P requirement for TPN.

Animals↗