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Biomedical subjects

Y Maki

Publications and source records attributed to Y Maki.

At least 181 records · Page 10Linked to original sources
PubMed1985

Effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one, a new anti-ulcer agent, on experimental acute and chronic ulcers.

The effects of 5-acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one (AG 629), a newly synthesized compound, on various experimentally induced ulcers were investigated. Oral or intraduodenal administration of AG 629 in a dose range of 25-100 mg/kg inhibited water-immersion stress ulcer, exertion ulcer, Shay ulcer, indometacin- and acetylsalicylic acid (ASA)-induced gastric ulcer, and indomethacin-induced small intestinal ulcer in rats, histamine-induced gastric ulcer in guinea pigs, and ASA-induced gastric ulcer in dogs, though it was not effective against cysteamine-induced duodenal ulcer in rats. AG 629 in doses of 6.3-25 mg/kg p.o. twice a day significantly promoted the healing of acetic acid- or thermal-cortisone-induced gastric ulcers and acetic acid-induced duodenal ulcers in rats. AG 629 (25-100 mg/kg i.d.) inhibited the secretion of gastric acid and pepsin in pylorus-ligated rats and the acid secretion stimulated by distension of the rat stomach with air, whereas this compound did not affect acid secretion stimulated by histamine, pentagastrin, carbachol or 2-deoxy-D-glucose. This study shows that AG 629 has both prophylactic and curative effects on various ulcers. The anti-ulcer effect of this agent seems to be mediated primarily by increasing mucosal resistance and secondarily by an antisecretory activity.

Acetates↗
PubMed1985

Reaction of 2'5'-dichloro-2'5'-dideoxyuridine with nucleophiles.

Reaction of 2',5'-dichlorouridine (1) with amines and thiols afforded 2-N-substituted 2',5'-anhydroisocytidine derivatives (2) and 2,2'-anhydro-5'-thiouridine derivatives (5), respectively. When 2,2'-anhydro-5'-acetylthiouridine (5a) was treated with NaOMe, 3',5'-S-cyclouridine (6) was obtained.

Amines↗
PubMed1984

Use of evoked responses to measure laser photoradiation tissue effects.

The amount of argon laser irradiation necessary to first produce marked changes in somatosensory evoked potentials when applied to the dorsal columns of cats was used to measure the enhancement of tissue response by fluorescein previously injected intravenously. The mean radiant exposure was roughly 2700 J/cm2 in normal control animals compared to a mean radiant exposure of only about 560 J/cm2 in animals given fluorescein. Thus, the presence of fluorescein in these tissues enhanced the laser's effectiveness by a factor of 5. We suggest the use of evoked responses as a measure of laser photobiological effectiveness.

Animals↗
PubMed1984

Accessory cerebral ventricle of the occipital lobe. Morphogenesis and clinical and pathological appearance.

Small separated accessory ventricles in the occipital lobe were observed in 21.3% of 404 patients, as seen by computerized tomogram. There was no significant preponderance in regard to sex or laterality. The accessory ventricles were clinically not significant. As seen at autopsy, accessory ventricles were found in the subcalcarine white matter, posterior to the occipital horn of the lateral ventricle, in 29.5% of 200 "normal" brains. Again, there were no significant sex and laterality differences. Accessory ventricles were never found in brains of fetuses or newborn babies. The youngest child in whom an accessory ventricle was found was 1 month old. No accessory ventricles were larger than 1 cm in diameter; they were slit-like, triangular or oval in shape. Histologically, they showed subtotal loss of the ependymal layer, subependymal gliosis, and/or fibrosis, and, in some cases, hyalinofibrotic capillary degeneration. Electron microscopy of the remaining ependymal cells in the accessory ventricle showed marked atrophy. Accessory ventricles are formed at the tip of the occipital horn postnatally through the expansion of the deep calcarine fissure, increase in brain volume in the region, and subsequent fusion of the mediolateral ventricular walls.

Adolescent↗
PubMed1984

DNA replication of simian virus 40 chromatin in digitonin-treated and saponin-treated permeable cells.

Permeable cell systems have been developed by treatment of simian virus 40 (SV40)-infected cells with digitonin or saponin for studying in vitro DNA replication of chromatin. SV40 DNA replicated efficiently in these systems in the presence of the four deoxyribonucleoside triphosphates, ATP, Mg2+, and the proper ionic environment. Analysis of the time course of the replicated SV40 DNA I, II and replicating intermediates by gel electrophoresis and autoradiography indicated that SV40 DNA replicated completely in the form of nucleoprotein complexes (SV40 chromatin).

Animals↗
PubMed1984

[A case of spinal epidural abscess in a renal transplant recipient].

A 44-year-old male underwent a cadaveric renal transplantation at the university hospital of Tsukuba on March 3, 1979. On June 11, 1979, he was discharged this hospital. Immunosuppressive therapy with azathioprine and methylprednisolone was done. On November 1, 1979, he developed back pain associated with fever. On November 3, 1979, he was admitted to the university hospital of Tsukuba. Laboratory study revealed leucocytosis. CRP inserum was positive. But pneumonia, urinary tract infection and infectious skin lesion were ruled out by physical, radiological and laboratory examination. On November 16, 1979, he became paraparetic. On the next day, he consulted the neurosurgical unit. Neurological findings were as follows: paraplegia, and hypesthesia and hypalgesia below the level of T4, and bilateral hyperrefrexia of P.T.R. and A.T.R. Lumbar myelogram revealed a complete block at the level T7. On November 17, 1979, a laminectomy from T4 through T7 was performed. The epidural abscess containing yellow pus was found and totally removed. Gram-positive rods were isolated on bacteriologic culture. On the 7th postoperative day, the sensory level dropped to L4 bilaterally and the muscle strength in the lower extremity became fair. About 3 years after operation, he became to be able to walk without cane. Discussion was made about this case together with previously reported cases.

Abscess↗
PubMed1984

[Psychiatric symptoms of patients with chronic subdural hematoma].

Thirty-two cases with chronic subdural hematoma in adults were analyzed from two standpoints; one is the characteristics of pre- and post-operative psychiatric symptoms, the other is the common factors in patients with post-operative psychiatric symptoms. The average age of subjects was 55.4 years, and psychiatric symptoms were noticed in 18 cases (56%). Main pre-operative psychiatric symptoms were disorders of intellectual capacity including memory and orientation disturbance and were able to be classified into amnestic syndrome and dementia according to DSM-3. Outcome in amnestic group was good in contrast to that in dementia group mostly complicated by post-operative psychiatric symptoms. Post-operative psychiatric symptoms were seen in 6 cases. The average age of these cases was 68.2 years which was higher than that of asymptomatic group. And these were classified as dementia according to DSM-3. Common factors in these 6 cases were as follows: Accompanied by marked pre-operative psychiatric symptoms. High age. Complicated by post-operative subdural fluid collection with certain mass effects. Long period from head injury to operation. Accompanied by other complications such as cirrhosis of liver and hypertension. Subdural fluid collection following surgery is a problem under discussion. We obtained favorable results by subdural-peritoneal shunt.

Adult↗
PubMed1984

Juxtasellar mycotic abscess.

A rare case of juxtasellar mycotic abscess with suprasellar extension is reported. The patient had double vision, only a mild abducens palsy, and no sign of inflammation, history of nasal sinusitis, or diabetes mellitus. Although a histologic examination showed massive fungal mycelia with thin capsules and no tumor cells, the neuroradiologic findings were like those in a clival chordoma or epidermoid tumor.

Adult↗
PubMed1984

[Orbital varix].

Explore the source record for details and available documents.

Female↗
PubMed1983

Pharmacological profile of AA-861, a 5-lipoxygenase inhibitor.

AA-861, a selective 5-lipoxygenase inhibitor, suppressed A23187-induced formations of 5-HETE and LTB4 in rat peritoneal macrophages. Immunologically-stimulated generation of SRS-A was also inhibited in guinea pig lung and rat peritoneal cavity. AA-861 had no effects on histamine release from rat mast cells or passive cutaneous anaphylaxis in rats. Essentially no antagonistic activity to LTD4 or histamine was observed. This compound exerted an obvious inhibition of allergic bronchoconstriction in guinea pigs and a moderate reduction of carrageenin-induced paw edema and pleurisy in rats. These findings suggest that SRS-A plays an important role in asthmatic and inflammatory reactions.

Animals↗