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Biomedical subjects

Y Lynfield

Publications and source records attributed to Y Lynfield.

At least 19 recordsLinked to original sources
PubMed1997

Pigmented sweat gland tumor mimicking melanoma.

Eccrine poroma, a common adnexal neoplasm, usually presents as a solitary, smooth, flesh-colored nodule on the foot or hand. Eccrine porocarcinoma is extremely rare and much more variable in its morphology and location. Both tumors can contain melanocytes and melanin. We describe a patient with an enlarging, eroded brownish black nodule on his shoulder. Examination of a biopsy specimen showed it to be derived from acrosyringium and to contain abundant melanin and scattered dendritic melanocytes. Eccrine poroma and porocarcinoma should be considered in the clinical differential diagnosis of pigmented tumors.

Acrospiroma↗
PubMed1996

Rhinophymalike metastatic carcinoma.

Cutaneous metastases from internal carcinoma vary in their clinical appearance. An unusual presentation, initially resembling rhinophyma, is described in a 71-year-old man with lung cancer. The clinical variations of metastases to skin are reviewed.

Aged↗
PubMed1995

Trivial or terrible? The psychosocial impact of psoriasis.

BACKGROUND: Psoriasis remains a chronic disease with lesions that are often extensive and disfiguring. While the potential for psychosocial morbidity and impairment are recognized, the literature remains equivocal with regard to the prevalence and degree of this impairment. METHODS: The present study utilized a new questionnaire designed to assess the type and degree of psychosocial impairment present among psoriasis patients. The questionnaire was designed to assess major areas of psychosocial functioning and was completed by 64 patients undergoing outpatient treatment. RESULTS: Approximately half the patients were found to have moderate to extreme levels of anxiety, depression, and anger. Patients reported experiencing these negative emotional sequelae both during their disease flares and during periods of remission. Patients were also found to have moderate to extreme levels of pruritus associated with their flares. Psychologic morbidity was positively associated with length of disease flare. Significant levels of social embarrassment, life disruption, and social withdrawal were found as well. CONCLUSIONS: Psoriasis does appear to cause significant psychosocial morbidity. Greater awareness by physicians and more comprehensive treatment addressing these psychosocial components may avert, or at least minimize, some of these negative sequelae.

Anger↗
PubMed1994

Relapsing polychondritis: case report and review of the literature.

A 65-year-old man who experienced the acute onset of pain, redness, and swelling of his right ear was treated with antibiotics for erysipelas. Subsequently, the other ear and both eyes became inflammed. Relapsing polychondritis was diagnosed and treatment with prednisone was successful. Relapsing polychondritis, a rare multisystem disease, presents most commonly with auricular chondritis. Other clinical manifestations include arthritis, nasal chondritis, scleritis, damage to tracheal and bronchial cartilage, and aortic, cardiac, and renal involvement. The cause is autoimmune. Recurrent episodes of progressive inflammation result in destruction of cartilage. Treatment consists of administration of corticosteroids and other anti-inflammatory and immunosuppressive drugs.

Aged↗
PubMed1993

Paraneoplastic pemphigus appearing as bullous pemphigoid-like eruption after palliative radiation therapy.

Paraneoplastic pemphigus is a recently described disease in which patients have polymorphous skin lesions suggestive of both erythema multiforme major and pemphigus vulgaris in association with internal neoplasms, especially non-Hodgkin's lymphoma. These patients have characteristic autoantibodies that bind specific epidermal proteins. A Nikolsky-negative bullous pemphigoid-like eruption developed within the radiation therapy field in a 72-year-old man receiving palliative treatment for recurrent large cell lymphoma. The eruption rapidly progressed to a Nikolsky-positive bullous process more typical of pemphigus vulgaris with extensive involvement of respiratory epithelia. Despite aggressive treatment with high-dose corticosteroids and antibiotics, the patient rapidly succumbed. Results of immunofluorescence studies and autopsy findings confirmed the diagnosis of paraneoplastic pemphigus.

Aged↗
PubMed1992

Scurvy.

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Ascorbic Acid↗
PubMed1990

Dialysis acne.

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Acne Vulgaris↗
PubMed1989

Sulconazole nitrate 1% cream in the treatment of chronic moccasin-type tinea pedis caused by Trichophyton rubrum.

Sulconazole nitrate 1% cream applied twice daily was compared with its vehicle in the treatment of 229 patients with chronic moccasin-type tinea pedis confirmed by positive results of a potassium hydroxide preparation. At admission in this randomized, double-blind, parallel multicenter trial, 131 patients had positive dermatophyte cultures; Trichophyton rubrum was identified in 121 (92%). After 4 weeks of treatment, patients were examined and, if necessary, were treated for an additional 2 weeks. Sulconazole cream was significantly more effective than the vehicle in the treatment of chronic T. rubrum tinea pedis; 57% of patients were cured by sulconazole, compared with 13% cured with the vehicle. Relapse rates, assessed 2 weeks after the end of treatment, were significantly lower in patients treated with sulconazole than in those receiving vehicle (27% vs 71%). The 103 patients with moccasin-type tinea pedis whose cultures were not positive for T. rubrum achieved similar results.

Adolescent↗