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Biomedical subjects

Y Ling

Publications and source records attributed to Y Ling.

At least 91 records · Page 5Linked to original sources
PubMed1992

In situ localization of Epstein-Barr virus in thymic carcinoma.

Epstein-Barr virus (EBV) genome is associated with a variety of lymphoid and epithelial malignancies. EBV DNA has been detected in some cases of thymic carcinoma, but the cellular locus of the virus has never been defined. Detection of EBV has also been reported in normal thymus, thymic lymphoid hyperplasia, and thymoma by some investigators but not by others. In order to better define the association of the virus with benign and malignant thymic tissues and to characterize its cellular locus, we applied a recently developed in situ hybridization technique using a very abundant EBV transcript (EBER1) as target to a variety of thymic tissues. We detected expression of this transcript only in the malignant epithelial cells in one case of thymic lymphoepithelioma-like carcinoma. EBV expression was not detected in six other cases of thymic carcinoma, nor in tissue from 16 normal thymuses, 14 thymomas, and 10 thymic lymphoid hyperplasias.

Adult↗
PubMed1992

Breast volume measurement in 125 young Chinese women.

The authors carried out research on breast volume and body surface anatomy of 125 unmarried young women. As a result, an average breast volume for young Chinese women was obtained (325.36 +/- 12.66 ml), and a table together with several linear equations for calculating breast volume were derived. These will provide plastic surgeons with useful tools for designing mammaplasty procedures.

Adolescent↗
PubMed1991

The nature and importance of the inter-epsilon chain disulfide bonds in human IgE.

IgE antibodies are best known for their pathological role in allergy. The class-specific effector sites are located in the epsilon chains; these form covalent dimers via two cystine residues (Cys241 and Cys328) linking opposite C epsilon 2 domains. The nature and biological significance of the inter-epsilon chain disulfide-bond arrangement is unresolved. For structural and functional analysis site-specific mutations were introduced into the C epsilon 2 domain of recombinant human IgE. The introduction of an additional cyanogen bromide cleavage site (His246----Met) facilitated the identification of parallel disulfide bond pairing. This linkage was also confirmed for myeloma IgE PS by sequence determination of disulfide-linked C epsilon 2 dimers. Substitution of Cys241 and Cys328 by Ser does not destroy receptor binding, but reductive alkylation, or the replacement of Cys328 by Met, leads to loss of activity. This shows that covalent dimerization is not essential for IgE/receptor interaction and points to the importance of the structural integrity of the site surrounding Cys328, visualized in a new model of human Fc epsilon.

Amino Acid Sequence↗
PubMed1989

Penetrating keratoplasty and raised intraocular pressure. A brief review of the problems and its management.

Postkeratoplasty glaucoma is a serious sight-threatening problem that is likely to remain with us for the foreseeable future. It is common yet unsatisfactory to deal with. It is only by meticulous assessment of patients and rigorous aftercare that the condition can be adequately managed. Modern surgical techniques may improve the prognosis in cases which are uncontrolled by traditional methods.

Corneal Transplantation↗
PubMed1988

The use of silicone drainage tubing to control post-keratoplasty glaucoma.

A series of 20 patients who developed severe post-keratoplasty glaucoma unresponsive to medical therapy and trabeculecetomy were treated using silicone drainage tubing and an anterior encircling gutter. The results indicate a four year probability of maintaining vision and normal intraocular pressure (less than 21 mmHg) of 0.68. In contrast, an earlier series of 13 patients receiving cycloablation with cryotherapy did significantly worse.

Anastomosis, Surgical↗