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Biomedical subjects

Y Levo

Publications and source records attributed to Y Levo.

At least 109 records · Page 6Linked to original sources
PubMed1985

Effects of serum amyloid P component on human lymphocytes.

The P component of amyloid is a normal serum protein designated SAP. SAP has substantial homology with C-reactive protein (CRP). Recent studies have established the structure, tissue distribution and binding reactivities of SAP; however, as yet, very minimal insight into its function has been achieved. Recent studies, though somewhat controversial, have suggested a regulatory role for CRP on the immune response. In view of these studies, we wanted to evaluate the in vitro effects of SAP on several immunological properties of human lymphocytes. We found that SAP had a marked inhibitory effect on the proliferative response of lymphocytes to a variety of T-dependent mitogens. In addition, SAP markedly enhanced the formation of active E rosettes, a marker of activated T cells.

Amyloid↗
PubMed1985

Sulfasalazine pneumonitis.

A patient with ulcerative colitis developed skin allergy to sulfasalazine, manifested by rash urticaria and generalized angioedema. The patient underwent desensitization with the drug. After desensitization, the drug was reinstituted without any adverse skin reaction. However, 2 months later the patient developed a severe pneumonitis that resolved completely on discontinuation of sulfasalazine and administration of steroids. The relationship between the various adverse reactions to the drug is discussed and the entity "sulfasalazine pneumonitis" is reviewed.

Angioedema↗
PubMed1985

Serum amyloid P-component as a marker of liver involvement in measles infection.

The P-component of amyloid (SAP) is a normal serum protein. Recent studies have pointed to the liver as the site of synthesis of SAP. Moreover, we have recently demonstrated a close correlation between serum level of SAP and the degree of liver impairment in patients with acute hepatitis, chronic active hepatitis, and cirrhosis. In the present study we have investigated liver involvement and serum SAP level during measles infection. Up to 80% of patients with measles had evidence of hepatic dysfunction. Serum SAP level was markedly decreased in patients with measles and correlated with the presence of liver involvement. Taken together, this finding suggests that serum SAP level might be a useful and sensitive indicator of liver disease.

Adolescent↗
PubMed1985

Serum IgE levels in patients with cancer.

Serum levels of IgE and carcinoembryonic antigen (CEA) were determined in 100 patients with carcinoma of the breast and 81 with colon carcinoma in different stages of their disease. CEA levels reflected the stage of the disease and increased progressively from stage 1 to 4. In contrast, all patients regardless of their type of malignancy, stage of the disease, or CEA level had a similar IgE blood level which did not differ from that of the control group.

Breast Neoplasms↗
PubMed1985

In vitro synthesis of IgE in atopic and nonatopic individuals: the effects of pokeweed mitogen, Staphylococcus aureus-derived mitogens, and cycloheximide.

We studied the production of immunoglobulin (Ig)E in cultures containing mononuclear cells obtained from atopic and nonatopic subjects. The two groups did not differ in their baseline production of IgE. Pokeweed mitogen (PWM) and three different products of Staphylococcus aureus: purified protein A, heat-killed formalinized bacteria, and double-formalinized bacteria--induced a significant increase in the in vitro production of IgE. Mononuclear cells from both atopic and nonatopic individuals were stimulated to the same degree by all four mitogens. The increased production of IgE by PWM was totally abolished by cycloheximide; hence it was due to de novo protein synthesis.

Adolescent↗
PubMed1985

Rapid improvement in a terminal case of hairy cell leukemia treated with a new human recombinant interferon, IFN-alpha-C.

A new type of human interferon (IFN), IFN-alpha-C, produced in Escherichia coli and purified on monoclonal antibodies, was given at a dose of 3 X 10(6) u (3 micrograms)/day to a terminally ill unsplenectomized patient with hairy cell leukemia, who had had severe recurrent infections and pancytopenia. There was marked reduction in the size of the spleen after 2 weeks, and platelet counts returned to normal after 1 month of treatment. The IFN treatment also raised the granulocyte counts and hemoglobin levels, improved the normal repopulation of the bone marrow, and restored resistance to infections. IFN-alpha-C was well tolerated, without serious side effects, and treatment has been continued for 10 months.

Cytotoxicity Tests, Immunologic↗
PubMed1984

Immunoglobulin E response during measles.

Serum IgE levels were determined in 41 patients with measles infection. 23 patients (56%) had an increased level (greater than 20%) during the acute phase of the disease in comparison with the recovery phase. 14 showed no change, and decreased levels were observed in 4 patients only. In contrast, both IgG and IgA levels decreased or remained unchanged in the majority of the patients during disease activity. The changes in the pattern of serum immunoglobulins during measles might be attributed to selective depletion of T-cell subpopulations.

Adolescent↗
PubMed1983

The association between autoimmunity and agnogenic myeloid metaplasia.

A patient with agnogenic myeloid metaplasia (AMM) associated with an ill-defined autoimmune disease is described and the literature on autoimmunity in AMM is reviewed. In view of the available data, it seems that the association between AMM and autoimmunity observed in our patient is not fortuitous.

Adult↗
PubMed1983

Infective endocarditis caused by uncommon bacteria.

The present study is an attempt to define the uncommon bacteria (UB) causing endocarditis and to evaluate their prevalence and clinical significance. Review of 13 series (including ours) revealed that UB were the infecting organisms in 105/1989 patients (5.3%). The leading bacteria were: Pneumococcus, Haemophilus sp., Corynebacterium sp., Neisseria sp., Streptobacillus moniliformis, Cardiobacterium hominis and Erysipelothrix sp. These data are similar to those obtained from 111 sporadic case reports published in English during the last 6 yr and cited in the Index Medicus. Infection by UB usually resembles that by the common bacteria. However, Haemophilus sp. seems to affect mainly the young and is associated with major arterial occlusions, and Brucella is claimed to have a greater affinity to the aortic valve. UB are more frequent in patients with polymicrobial infections and their diagnosis is often delayed. Greater awareness to the possibility of infections with UB is needed for early diagnosis and improved prognosis.

Adolescent↗
PubMed1982

The association between Kaposi's sarcoma and dysgammaglobulinemia.

The case of a patient with Kaposi's sarcoma and paraproteinemia is described and the relevant literature is reviewed. It is suggested that Kaposi's sarcoma is part of the spectrum of the lymphoproliferative diseases, and that both the marked angiogenesis and the synthesis of paraproteins in this disease are different expressions of the same proliferative process.

Adult↗
PubMed1982

Diagnosis and classification of amyloidosis by an immuno-histological method.

Following the recent classification of amyloidosis by the amyloid proteins involved, we decided to approach its tissue diagnosis and chemical classification by an immunohistological method. Post-mortem tissue specimens from various organs of patients with primary and secondary amyloidosis were examined by the immunoperoxidase technique with specific antibodies against proteins AL and AA which respectively characterize primary and secondary amyloidosis. The major advantage of this technique is that it can be applied to formalin fixed, paraffin embedded tissues. The immunoperoxidase technique proved to be extremely sensitive for the detection of amyloid deposits. Moreover, the deposited proteins could be clearly characterized as AL or AA by the specific anti-sera. We therefore believe that the immunooperoxidase technique is extremely useful for the early tissue diagnosis and chemical classification of amyloidosis.

Amyloid↗
PubMed1982

Pneumococcal epiglottitis in systemic lupus erythematosus on high-dose corticosteroids.

A patient with systemic lupus erythematosus who developed pneumococcal epiglottitis is described and the literature reviewed. This infection is extremely rare in adults, and only 10 cases, none of them with SLE, have so far been reported. Epiglottitis is usually caused by Haemophilus influenzae. However, in immunocompromised hosts the probability of Streptococcus pneumoniae as the infecting agent is considerable. Penicillin should therefore be part of the antimicrobial regimen in such patients.

Adult↗
PubMed1982

Presence of fibronectin in cold precipitates of patients with cryoimmunoglobulinemia.

Fibronectin (FN) has been implicated in the cryoprecipitation of fibrin-fibrinogen complexes. Preliminary observations have suggested that it may also play a role in cryoglobulinemia. In the present study 32 cryoprecipitates from patients with hepatitis, chronic active hepatitis, essential mixed cryoglobulinemia, and inflammatory bowel diseases were analyzed and screened for the presence of FN. Most cryoproteins of patients with essential mixed cryoglobulinemia and inflammatory bowel diseases were of the mixed IgM-IgG type and all contained FN. In contrast, most cryoproteins of patients with hepatitis were composed of polyclonal IgM and were devoid of FN. It is possible that FN characterizes and facilitates the formation of mixed cryoglobulins. However, its presence does not seem to be an absolute requirement for cryoprecipitation.

Chemical Precipitation↗