[Interferon therapy in hematological malignancies].
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Humans↗
Biomedical subjects
Y Levo
Publications and source records attributed to Y Levo.
[Hypersensitivity to streptokinase].
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Drug Hypersensitivity↗
Serum amyloid P-component levels in patients with malignancy.
The P component of amyloid is a normal serum protein designated SAP. SAP has substantial homology with C-reactive protein (CRP). However, unlike CRP, SAP is not an acute-phase reactant in man. Recent studies have established SAP as a major acute-phase protein in mice. Moreover, mice which have received tumour implants have also been found to have raised serum concentrations of SAP. The aim of the present study was to determine possible association between the serum level of SAP and human cancer. We found that patients with carcinoma of the breast have significantly increased serum concentrations of SAP. Moreover, in these patients SAP levels correlated with the severity of the disease. Patients with carcinoma of the colon, however, did not differ from healthy individuals in the serum level of SAP. Possible explanations for this discrepancy are discussed.
Amyloid↗
The regulatory effect of histamine on the in vitro synthesis of IgE.
The effect of histamine and its H1 and H2 antagonists, chlorpheniramine and cimetidine, on the in vitro, PWM-induced, synthesis of IgG and IgE was studied. Histamine had no effect, and cimetidine had a slight inhibitory action. In contrast, chlorpheniramine induced marked suppression of both IgE and IgG synthesis. This effect could not be attributed to drug-induced cytotoxicity. These results suggest that the modulatory effect of histamine on antibody production involves predominantly H1 receptors.
Cell Survival↗
Septicemia caused by the gram-negative bacterium CDC IV c-2 in an immunocompromised human.
A 37-year-old man with plasma cell leukemia developed nonfatal septicemia caused by the gram-negative bacterium CDC IV c-2. Recovery followed appropriate treatment with antibiotics. The biochemical features of this organism are reviewed.
Adult↗
Budd-Chiari syndrome as the major thrombotic complication of systemic lupus erythematosus with the lupus anticoagulant.
A patient with systemic lupus erythematosus was first diagnosed after she had developed the Budd-Chiari syndrome. We believe that the Budd-Chiari syndrome was part of her tendency for thrombosis, induced by the presence of a lupus anticoagulant. The association between enhanced thrombosis and the lupus anticoagulant is discussed, and the need for prompt recognition and administration of anticoagulant therapy is emphasised.
Adult↗
The case of the bulging Bulgarian.
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Aged↗
Hypersensitivity pneumonitis induced by nalidixic acid.
Interstitial pneumonitis developed in a patient one week after therapy with nalidixic acid was initiated. The causal association between the drug and the lung disease is based on the temporal relationship, an increased eosinophil count in both peripheral blood and fluid obtained by bronchoalveolar lavage, a positive migration inhibitory factor test with nalidixic acid, and exclusion of other causes. This is, to the best of our knowledge, the first report of a pulmonary hypersensitivity reaction to nalidixic acid.
Aged↗
Longstanding intractable ascites as the initial and predominant manifestation of systemic lupus erythematosus.
Peritoneal involvement is quite common in systemic lupus erythematosus (SLE). However, significant ascites as the predominant manisfestations of SLE is extremely rare, and very few cases have been reported. We describe a patient with SLE whose disease first manifested as longstanding, painless and intractable ascites. The ascites preceded the diagnosis of SLE by 3 years. The diagnosis of SLE should be considered in patients with the so called "idiopathic" ascites. Once diagnosed, the ascites seem to respond promptly to corticosteroids, however, prior to their administration other potential causes, especially infections and malignancy, should be ruled out.
Adult↗
Cardiac tamponade in the early postpartum period as the presenting and predominant manifestation of systemic lupus erythematosus.
Pericarditis is a common manifestation of systemic lupus erythematosus (SLE), however, tamponade seems to be extremely rare. A review of the English literature revealed 12 such cases and in 5 the tamponade was the presenting symptom of the disease. We describe an additional patient. She developed pericardial tamponade one week after delivery of a healthy child, and subsequently was diagnosed to have SLE. The effect of pregnancy and the postpartum period on SLE is discussed.
Adult↗
[Physician staff requirements for a medical ward in Israel].
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Hospital Units↗
Serum IgE levels in patients with inflammatory bowel disease.
The role of allergy in the pathogenesis of inflammatory bowel disease (IBD) is unclear. The present study was performed to evaluate serum levels of IgE and other immunoglobulin classes in patients with IBD. Patients with IBD had significantly elevated serum levels of both IgG and IgM in the presence of normal levels of IgA. Serum concentration of IgE, as well as the prevalence of patients with "high IgE" were significantly increased in IBD. Among patients with IBD, those with Crohn's disease or those in relapse had the highest levels of IgE. The possibility that allergy plays a pathogenic role in a subset of IBD is discussed.
Adolescent↗
Cachectin/tumour-necrosis-factor production by cancer patients.
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Glycoproteins↗
The regulatory effect of macrophages on the in vitro synthesis of IgE.
The effects of indomethacin or macrophage-depletion on the in vitro unstimulated and pokeweed mitogen (PWM)-induced synthesis of IgG and IgE were compared. The effect on the unstimulated synthesis of IgG and IgE was similar, namely, no effect due to indomethacin and enhancement due to macrophage depletion. In contrast, the effect on PWM-induced synthesis was dissimilar. Macrophage depletion enhanced IgG but inhibited IgE production. The effect of indomethacin paralleled that of macrophage depletion suggesting the involvement of prostaglandins. It seems that the regulatory effect of macrophages is different in the IgE system compared with the IgG system.
Antigen-Presenting Cells↗
Severe hemochromatosis: the predominant clinical manifestation of congenital dyserythropoietic anemia type 2.
A patient with multiorgan involvement of non-iatrogenic hemochromatosis secondary to congenital dyserythropoietic anemia (CDA) type 2 is described. The clinical manifestations of hemochromatosis preceded the diagnosis of CDA. CDA should be included among the hematological disorders associated with iron overload. Iron therapy and blood transfusions should be avoided if possible in patients with CDA, and all such patients should be carefully screened for the known complications of iron overload.
Adult↗
Regulatory effect of hydrocortisone on the in vitro synthesis of IgE by human lymphocytes.
The effect of different concentrations of hydrocortisone (HC) on the in vitro, pokeweed mitogen-driven synthesis of IgG and IgE by human lymphocytes was studied. HC had the same modulatory action on the production of both immunoglobulins. Two different effects were observed: the first is enhancement of Ig synthesis by low concentrations of HC (10(-7)-10(-4) M), and the second is inhibition of synthesis by higher concentrations due to lymphocytotoxic effect.
Cell Survival↗