A preliminary cytochemical study of mucus in chronic secretory otitis media and possible correlations with anatomical evolution tympanum.
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Cell Count↗
Biomedical subjects
Y Lasne
Publications and source records attributed to Y Lasne.
[Proceedings: Fetal adrenal gland 17-hydroxycorticosteroid secretion: comparison between infants born at term and by prophylactic cesarean section].
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17-Hydroxycorticosteroids↗
Bronchoalveolar lavage in radiation pneumonitis.
Bronchoalveolar lavage (BAL) was carried out in six patients with radiation pneumonitis, the early radiation-induced lung damage that usually leads to radiation fibrosis. Protein analysis by immuno-electrophoresis and polyacrylamide gel electrophoresis of BAL fluid revealed leakage of circulatory proteins, including high molecular weight components. Cell count of BAL fluid showed an increased number of lymphocytes; these proved to be activated on cell cycle analysis in one patient. Collagenolytic activity, assessed by degradation of radiolabelled type I human collagen, was present in BAL fluid of all six patients. The following mechanisms are therefore considered to participate in the pathogenesis of radiation-induced lung damage: 1) permeability oedema, which led to acute respiratory distress syndrome in one case of hyperacute radiation pneumonitis, 2) lymphocyte alveolitis possibly perpetuated by activated lymphocytes, and 3) release of collagenolytic enzymes in alveolar structures contributing to fibrotic processes.
Bronchi↗
[The protein profile. Statistical treatment and use of the results, principles and applications].
The serum protein profile is a biological multi parametric analysis. Its validity will be tested by multidimensional statistical treatment to help the medical decisions and the practical exploitation of the results. The mean and the range are given by classical methods which also allow the correlations of some proteins. The factorial analysis of the tables of correlations by showing the proximities between the proteins and the pathological classes gives a first indication of the structure of the data. The multidimensional approach introduces the notion of distance between two profiles, gives an automatic classification of the profiles in distinct groups and an evaluation of these groups as real pathological entities. A table of distance between the profiles can also discriminate between the groups of patients. However the biological model implies some hypotheses: does any disease imply a specific profile and the reverse? Are the variations of each protein compatible and do they require some pondering? Therefore the best in the present time is to try a multidimensional approach as an help for medical decision rather than an automatic mean of diagnosis.
Blood Proteins↗