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Biomedical subjects

Y Kondo

Publications and source records attributed to Y Kondo.

At least 991 records · Page 55Linked to original sources
PubMed1975

Comparison of the cardiac output measurements with electromagnetic flowmeter and dye-dilution technique in dogs, with a note on the comparison between radiocardiography and ear-dye method in man.

There are relatively few studies and opinions are still divided as to the agreement between the electromagnetic flowmeter and dye-dilution technique in measurements of cardiac output in animals. Of 22 pairs of cardiac output measurements performed with an electromagnetic flow probe applied to the root of aorta in open-chest, anesthetized dogs and with peripheral venous injection of indocyanine green dye and an arterial cuvette, the measured points fell within the range of plus or minus 20% on both sides of the line of identity in 19 instances. Studied on 8 human subjects with radiocardiography and ear-dye method performed simultaneously with peripheral venous injection of a mixture of R131ISA and indocyanine green, cardiac output given by ear-dye method was higher than that given by radiocardiography by an average of 9 plus or minus 11 (SD)%. Agreement and disagreement in cardiac output measurements given by electromagnetic flow probe, dye-dilution method with arterial cuvette, dye-dilution method with ear-piece densitometer and radiocardiography were discussed.

Animals↗
PubMed1975

The mean circulatory pressure, reproducibility of its measurements and the effect of phenylephrine with a note on the effect of pentobarbital.

With 7 repeated measurements of the mean circulatory pressure (MCP) over a course of 35 minutes in one and the same dog, and also with paired measurements of MCP 10 minutes apart in 6 other dogs, the MCP was shown to be stable and reproducible in anesthetized, open-chest and vagus-intact dogs. Administered to 7 dogs with initial mean arterial blood pressure as low as 64 mmHg in dose of 20 mug/kg intravenously, phenylephrine nearly doubled the mean arterial blood pressure, total peripheral resistance and the MCP, indicating a marked vasoconstrictor effect on the resistance and capacitance blood vessels of the systemic circulation. The effect was transient and there were signs of tachyphylaxis. Influence of a cardiotoxic dose of pentobarbital on the peripheal circulation was discussed.

Animals↗
PubMed1975

Inhibition of dopamine-beta-hydroxylase by carnosine.

Dopamine-beta-hydroxylase was partially purified from bovine adrenal medulla and the effect of carnosine on the dopamine-beta-hydroxylase activity was investigated. Carnosine significantly inhibited the enzyme activity at the concentrations higher than 0.5 mM. According to the Lineweaver-Burk plots, the inhibition observed appeared to be a non-competitive type with the substrate, tyramine.

Animals↗
PubMed1975

Successful orthotopic allotransplantation of hearts from dogs in irreversible shock.

The viability of the heart from irreversibly shocked dogs was evaluated. Thirty-one mongrel dogs were used to develop a uniformly lethal hemorrhagic shock model. The final model utilized a 30 mm. Hg mean arterial pressure with a 40 percent decompensation (uptake of reservoir blood). All control dogs subjected to this procedure died within 24 hours. Eleven hearts were transplanted following the shock procedure. Blood samples were drawn at intervals and analyzed for Po2, pH, glucose, oxygen content, and hematocrit. Cardiac outputs and ECG's were taken before and after transplant. All parameters measured returned to control levels following the transplants. Of the dogs receiving heart transplants, 10 survived more than 24 hours and eight survived more than 7 days. Compared with the survival of the shock model experiments, the survival of the transplant recipients was significant at the p less than 0.01 level. These results suggest that deterioration of the heart is not the factor which prevents recovery from irreversible hemorrhagic shock.

Animals↗
PubMed1975

Heart transplantation in endotoxin shock.

The condition of the heart from dogs in endotoxin shock was evaluated, and all dogs in the control group receiving 5 milligrams per kilogram to Eschericia coli endotoxin died within two to 14 hours. Hearts from four other dogs receiving the same dosage of endotoxin were allografted orthotopically into healthy recipient dogs. The donor heart was taken in the terminal phase of shock, after the blood pressure of the donor had declined to 50 millimeters of mercury or less. All four heart allografts functioned normally in the healthy hosts, demonstrating that lethal levels of gram-negative endotoxin do not produce direct irreversible damage to the myocardium or to the conduction mechanism of the heart. This also was shown in one pair of monkeys; the donor monkey had received ten times the dosage of endotoxin used in the dogs. This heart transplant model offers considerable advantage in functional studies of the heart after irreversible shock.

Animals↗