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Biomedical subjects

Y Kondo

Publications and source records attributed to Y Kondo.

At least 829 records · Page 46Linked to original sources
PubMed1985

[Effect of HPS on leucocytozoon and coccidial infection in chickens].

The effect of HPS (halofuginonepolystyrene sulfonate), a derivative of halofuginone with lower toxicity, on natural leucocytozoon and coccidial infection in broiler chickens was evaluated in a floor pen trial. The experiment was conducted from one day to 10 weeks of age. On leucocytozoon infection, HPS added to the diet was completely effective at 60 ppm, fairly effective at 40 ppm and ineffective at 20 ppm. On the other hand, HPS concentrations of 20 ppm, 40 ppm and 60 ppm were completely effective on coccidial infection. HPS at 40 ppm which corresponds to the recommended level of halofuginone (3 ppm) and at 60 ppm had no adverse effect on the weight gain in experimental birds.

Animals↗
PubMed1985

[Effect of sulfaquinoxaline and diaveridine on leucocytozoon infection in chickens].

The preventive effect of sulfaquinoxaline and diaveridine in combination against leucocytozoon infection in White Leghorn female chickens was tested in a field trial. The experiment was initiated when the animals were 120 days old, and it lasted for 10 weeks. The medication was given for the first seven days, and no medication was given for the next seven days; then this schedule for the medication was repeated throughout the experimental period. The almost complete preventive effect was obtained when sulfaquinoxaline and diaveridine were added to the feed at the level of 16 ppm and 4 ppm, respectively, or at the level of 8 ppm and 2 ppm, respectively. On the other hand, only a partial effect was obtained when these drugs were used at the level of 4 ppm and 1 ppm, respectively. These medications had no adverse effect on the weight gain in the experimental birds.

Animals↗
PubMed1985

[Occupational stress of assembly line female workers in confectionery work].

Concomitant with frequent occurrence of disorders of the neck, arm, hand and low back among assembly-line female workers in confectionery work, there is an increased number of patients with occupational cervicobrachial disorders and/or low back pain. In suspicion of the close correlation between the working conditions and development of these local disorders, a field study was undertaken. The following are the results obtained. More than 90% of these assembly-line female workers consisted of inexperienced part-time employees, mostly of middle to old age. They were engaged in decorating conveyor-carried cakes with cream and chocolate. The work necessitated repetitive movements of the upper limbs and concentration of visuosensory and nervous attention in a half-sitting slouching posture. This was considered to exert excess load on the local muscles and nervous and sensory systems. The causes that intensified the local symptoms as pointed out by the workers consisted of (1) repetitive use of the arms and hands, (2) static posture during the work and (3) sustained standing position. Complaints of low back pain were conspicuous from the unsuitable height of a conveyor-belt. Thirty five percent of the female workers needed medical treatment for cervicobrachial and/or low back pain. The forced adaptation to the belt height, sustained unnatural working posture and the imposition of forced movements seemed to be the main factors in the onset of cervicobrachial and/or low back pain in interrelation with working hours. On the basis of these results, the work load on a machine-paced assembly-line was analyzed and the necessity of improvement of working conditions was discussed.

Adult↗
PubMed1985

Postheparin plasma lipoprotein lipase activity in heterozygotes of familial lipoprotein lipase deficiency.

Serum lipoprotein pattern, apoproteins and two postheparin triglyceride lipases were analyzed in a patient with familial lipoprotein lipase (LPL) deficiency and her family. Serum of the patient showed extreme hyperchylomicronemia and her postheparin plasma LPL activity was distinctly decreased. None of heterozygotes had any type of hyperlipoproteinemia. The mother and brother of the patient had moderately decreased LPL activity. There were no consistent changes in hepatic triglyceride lipase (H-TGL) activity among heterozygotes. These results suggest that assay of LPL may be helpful for detection of heterozygotes in familial LPL deficiency.

Adult↗
PubMed1985

Studies of hydroxypropylmethylcellulose acetate succinate on fertility in rats.

A fertility study was carried out in Slc: SD rats orally administered Hydroxypropylmethylcellulose acetate succinate (HPMCAS), a useful pharmaceutical excipient, at dose levels of 625, 1,250 and 2,500 mg/kg/day. Male rats were treated with HPMCAS from 60 days before pairing until the completion of mating. Female rats received HPMCAS for 22 days, from 14 days prior to mating up to Day 7 of gestation. All pregnant females were sacrificed on Day 21 of gestation and all fetuses were examined for abnormalities. No abnormal signs were seen in mating or fertility in the rat treated with HPMCAS. No external, internal and skeletal anomalies attributable to HPMCAS were observed in the fetuses. It was concluded that HPMCAS had no harmful effect on mating, fertilization, implantation, or embryonic development.

Administration, Oral↗
PubMed1985

Teratological studies of hydroxypropylmethylcellulose acetate succinate in rats.

A teratogenicity study was carried out in S1c: SD rats orally administered Hydroxypropylmethylcellulose acetate succinate (HPMCAS), a useful pharmaceutical excipient, at dose levels of 625, 1,250 and 2,500 mg/kg/day for a period of 11 days from day 7 to day 17 of gestation. Two-thirds of the pregnant females in each group were sacrificed on Day 21 of gestation and their fetuses were examined. The remaining dams were allowed to litter naturally, and the postnatal development of the offsprings was observed. The incidences of external, internal, and skeletal anomalies were not significantly increased in the fetuses of any treated groups. HPMCAS caused no effects on parturition, lactation, postnatal growth and reproductive ability of the male and female offspring.

Abnormalities, Drug-Induced↗
PubMed1985

Teratological study of hydroxypropylmethylcellulose acetate succinate in rabbits.

A teratological study was carried out in New Zealand White rabbits in order to examine the teratogenic potentiality of HPMCAS, a useful pharmaceutical excipient. HPMCAS was orally administered at dose levels of 625, 1,250 and 2,500 mg/kg/day for a period of 13 days from day 6 to day 18 of gestation. All pregnant females were sacrificed on day 29 of gestation and their fetuses were examined. The administration of HPMCAS during a period of organogenesis produced no embryotoxic and teratogenic effects as well as no influence on behavior, appearance and growth of animals.

Abnormalities, Drug-Induced↗
PubMed1985

Effects on offspring induced by oral administration of hydroxypropylmethylcellulose acetate succinate to the female rats in peri- and post-natal periods.

A perinatal and postnatal study was carried out in Slc: SD rats orally administered Hydroxypropylmethylcellulose acetate succinate (HPMCAS), a useful pharmaceutical excipient, at dose levels of 625, 1,250 and 2,500 mg/kg/day for a period from day 17 of gestation to day 21 after delivery. All pregnant rats were allowed to litter naturally, and the postnatal development of the offsprings was observed. In the administered group of 2500 mg/kg, the liver weight was significantly increased in males and showed a tendency to increase in females as compared with control. No significant differences between the control group and the administered groups were found in postnatal growth and differentiation, behavior and reproductive ability of male and female offsprings.

Administration, Oral↗
PubMed1985

Effect of sinomenine on antibody responses in mice.

Sinomenine, an epimorphinan alkaloid, was tested for the immunosuppressive effect in mice. This compound produced a decrease of plaque-forming cells (PFC) to a T cell-dependent antigen, sheep red blood cells, in vivo. The depression of the PFC response induced with sinomenine was dose and time dependent. On the other hand, it failed to suppress the PFC response to a T cell-independent antigen, lipopolysaccharide. The immunosuppressive dose of sinomenine did not alter the cellularity of spleen, thymus, bone marrow and peripheral blood leucocytes, the DNA synthesis activity of bone marrow cells nor the proliferative responses of spleen cells induced by T cell and B cell mitogens in unprimed mice. These data suggest a selective effect of sinomenine on lymphoid cells. This compound has a potential for use in studies of immuno-deficiencies or clarifying some aspect of immunity.

Animals↗