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Biomedical subjects

Y Kojima

Publications and source records attributed to Y Kojima.

At least 415 records · Page 23Linked to original sources
PubMed1987

Urinary 3-methylthiopropionate excretion and the effect of D- or L-methionine ingestion studied in healthy subjects.

After overnight fasting, the urinary concentrations of 3-methylthiopropionate in 23 healthy male subjects aged from 17 to 72 were studied by gas chromatography and flame photometry. The urinary 3-methylthiopropionate concentrations after fasting showed an approximately normal distribution in the logarithmic scale (M +/- SD = 0.953 +/- 0.394): 10M = 8.97, 10M-SD = 3.62 and 10M + SD = 22.23 ng/mg Creatinine. In 6 volunteers, a 2g D- or L-methionine loading test was also performed. Following D-methionine ingestion, urinary 3-methylthiopropionate concentrations over a 1-hour period increased 22- to 95-fold above those of the pre- loading values and then decreased in an approximately linear manner on semilogarithmic graph paper during a further 2- or 3-hour observation period, after which the examination ended. The mean amount of 3-methylthiopropionate excreted in the urine 3 hrs after loading was 147.7 micrograms (n = 6). Following L-methionine ingestion, by contrast, the increases in 3-methylthiopropionate concentrations over a 1-hr period were 0.3- to 8.3-fold above those of the preloading values. The mean urinary excretion of 3-methylthiopropionate 3 hrs after loading was 3.58 micrograms (n = 4). Because of the simple and specific analytical procedure, quantitative determination of urinary 3-methylthiopropionate is useful in the study of human methionine metabolism.

Adolescent↗
PubMed1987

Extra-adrenal pheochromocytoma manifesting renovascular hypertension.

A case with extra-adrenal pheochromocytoma, which was found by chance in the course of renovascular hypertension, is reported. The tumor was on the stenotic portion of the right renal artery. The results of examinations for pheochromocytoma were not conclusive, that is, inconsistent elevation of plasma catecholamines and urinary catecholamine excretion, equivocal results of pharmacological tests for pheochromocytoma, and negative results in [131I]metaiodobenzylguanidine scintigraphy. The stenosis of the right renal artery disappeared, the blood pressure was normalized by surgical resection of the tumor, and the extra-adrenal pheochromocytoma was finally diagnosed by pathohistological findings. Renovascular hypertension appeared to be the primary cause of this hypertension, judging from the significant decrease in blood pressure induced by an angiotensin II analog and a renal vein renin ratio of 7.3. Even in the case of obvious renovascular hypertension, the possibility of this unusual coexistence with pheochromocytoma should be considered.

Adult↗