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Biomedical subjects

Y Kohli

Publications and source records attributed to Y Kohli.

79 records · Page 5Linked to original sources
PubMed1975

Evaluation of linear gastric ulcer as a precancerous lesion.

During the recent 13 years from 1961 to 1973, 21 cases of ulcer-carcinoma satisfying Hauser's pathologic criteria have been found endoscopically, 5 cases (2.6%) of which were mucosal carcinoma accompanying linear ulcer over 30 min in length. In addition, one submucosal carcinoma and 2 cases of sub-early gastric carcinoma, partially invaded into the proper muscle layer, were used for this study. Using these 8 cases and 11 operated ones of benign linear ulcer, we have a comprehensive study of histologic and clinical findings of both groups. As the results, malignant linear ulcer was similar in condition to the benign, either in mother ground or in histologic and clinical findings. Moreover, coexistent carcinoma with all kinds of gastric ulcer and with linear ulcer among them was found in 1.5% and 3.8%, respectively. In a series of controlled group, early gastric carcinoma was found in 2.1% out of 284 cases of no ulcer scar from its follow-up study. Its x2 test revealed no significant difference among these values. However, we might conclude that endoscopical follow-up study of chronic gastric ulcer, especially long linear ulcer, is indispensable for understanding the evaluation of malignant change of ch ronic gastric ulcer.

Adult↗
PubMed1975

Dispersion analysis of prognostic and relapsing factors of duodenal ulcer by use of electron computer.

Among 192 cases of duodenal ulcers and ulcer scars, which were endoscopically observed in the last three years, complete healing was observed in 109 cases. Study of the data in these cases by computer indicates that the healing tendency of duodenal ulcer is poorer with advancing age. It is less in a linear ulcer than in a round or irregularly shaped one and worse in an ulcer without marginal swelling than in one with it. Shape, number, distribution of lesions and degree of radiological deformity of duodenal cap are of no use in prognosis. Ulcer scars with redness or converged folds, however, are apt to relapse.

Adolescent↗
PubMed1975

Cell kinetics of gastric carcinoma and other gastric lesions in rats by N-methyl-N'-nitro-N-nitrosoguanidine with or without Tween 60.

Male Wistar rats were divided into three groups for studying the chronic effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), in continuous dose of 50 mg/L in drinking water, or 50 mg/L MNNG and 0.4% Tween 60 in drinking water. From the 2nd to 50th week after the administration of MNNG, every 3 or 5 rats were sacrificed and autopsied after the intraperitoneal injection of 1 muCi 3-H-thymidine/g body weight at 2- or 3-week intervals. The resected stomachs were studied morphologically and autoradiographically. Six cases of experimental gastric cancer were produced that fulfilled Stewart's criteria. Autoradiographically, there was no significant different in the flash labeling index in the normal antral mucosa, in the non-pathologic antral mucosa, and in the cancerous lesion, but generation time and DNA synthesizing time of the cancerous lesion were 2 or 3 times longer than those of the glandular stomach of normal rats reported by Galjaard. They were also longer than those of the non-pathologic antral mucosa of rats treated with MNNG. These experiments results were discussed, comparing with cell kinetics of the gastrointestinal tracts in man.

Administration, Oral↗
PubMedDate not supplied

Genetic heterogeneity of combined gastric and duodenal ulcers detected by pepsinogen C gene polymorphism.

It has been reported recently that there was genetic heterogeneity in gastric ulcer disease depending upon the location of the ulcer, and that there was a significant association between the restriction fragment length polymorphism (RFLP) for pepsinogen C (PGC) gene and gastric body ulcer. In the present study, the association of the RFLP for PGC gene with combined gastric and duodenal ulcers was investigated to analyse genetic factors in its aetiology. Eighty unrelated controls and 47 patients with combined gastric and duodenal ulcers were studied. The allele frequencies of the large (3.6 kilobase EcoRI fragment) and the small fragment (3.5 kilobase EcoRI fragment) were, respectively 80.6 and 19.4% in controls, 60.0 and 40.0% in patients with combined gastric body and duodenal ulcers, 69.0 and 31.0% in patients with combined gastric angular and duodenal ulcers, and 81.8 and 18.2% in patients with combined gastric antral and duodenal ulcers. The allele frequency of the small fragment was significantly higher in patients with combined gastric body and duodenal ulcers than in controls. The genotypes that possessed the small fragment were significantly more frequent in patients with combined gastric body and duodenal ulcers (66.7%) than in controls (33.8%) and combined gastric antral and duodenal ulcers (27.3%). These results suggest that there is genetic heterogeneity in combined gastric and duodenal ulcers depending upon the location of gastric ulcer, and that combined gastric body and duodenal ulcers are associated with the small fragment allele of the PGC RFLP in the same way as solitary gastric body ulcers.

Blotting, Southern↗
PubMedDate not supplied

New trial for endoscopical observation of esophagus by dye spraying method.

The Lugol dye spraying method in endoscopy is compared with the usual endoscopy. Its diagnostic values are discussed from the endoscopical and histological point of views. Normal esophageal epithelium is stained brown or dark brown with 5% of Lugol's solution, and shows a "silk-crape" like surface appearance when observed close up. The cancerous or inflammatory epithelium of the stomach and esophagus do not stain. With the sue of directed biopsy this reveals the usefulness of this method, specially for finding small esophagel cancer and for accurately delineating the extent of a cancer. Furthermore, esophagitis is easier to diagnose. As healing occurs, the staining characteristic return. Esophageal epithelium capacity for staining with Lugol's solution seems to be related to the glycogen content of the squamous epithelium.

Esophageal Diseases↗