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Biomedical subjects

Y Kim

Publications and source records attributed to Y Kim.

At least 973 records · Page 54Linked to original sources
PubMed1975

Glucocorticoid inhibition of protein synthesis in vivo and in vitro.

In young adult rats receiving glucocorticoids in pharmacological amounts, the accumulation proteins in the liver was suppressed. In vivo pulse-labeling experiments showed that inhibition of protein synthesis in the liver was an early effect of a single dose of glucocorticoid followed by a stimulation of protein synthesis. In animals receiving multiple doses of glucocorticoid over a period of a few days, a more pronounced inhibition in protein synthesis was observed, and the secondary stimulation of protein synthesis did not occur. These in vivo observations were paralleled by the results with cell-free protein-synthesizing systems, which indicated that the glucocorticoid inhibitory effect was imparted to the soluble fraction of the liver.

Animals↗
PubMed1975

Optic ataxia: clinical-radiological correlations with the EMIscan.

After coronary by-pass surgery, a 47 year old, right-handed man developed Gerstmann's syndrome, a visual-spatial perceptual deficit, and a gross impairment of movememt under visual guidance ("optic ataxia"). Visual fields and extraocular movements were intact; he had a left hemiparesis. The EMIscan showed three lesions: a left parietal-occipital lesion; a posterior callosal lesion, and a right frontal lesion. It is hypothesized that optic ataxia in both visual fields requires bilateral lesions which, in the present case, were strategically placed so as to effectively disconnect motor cortex from visual input.

Ataxia↗
PubMed1975

A further study on fast and slow principal cells of rat lateral geniculate body: an analysis of flash-evoked responses.

In the lateral geniculate body (LGB) of urethane-anesthetized and Flaxedil-immobilized rats, unit responses of principal cells (P-cells) were recorded by using flash stimulation of the eyes. By measuring response latencies to electrical stimulation of the optic tract, all P-cells were classified into the fastor slow group according to the criterion established by Fukuda. Flash-evoked unit responses consisted of the two kinds of discharges, i.e. the early discharge (ED) with latencies less than 100 msec and the late discharges of spike burst (LDs) often recurring twice or more (LD1, LD2 and so on). Cells' firings were suppressed during the interval between ED and LD1 and those between successive LDs. The ED- and LD1-latencies, measured in dark with strong flashes, were shorter in the fast cells than in the slow one. The interval between ED and LD1 was shorter in the fast cells than in the slow ones. It was common to the both types of P-cells that as flash intensity was reduced, the ED-latency increased and the LD1-latency decreased. However, the ED-LD1 interval remained shorter in the fast cells than in the slow ones. Upon shifting from dark to light, the LD1-latency markedly increased or decreased in the slow cells, whereas such was not seen in the fast cells. These findings seem to provide a further support for the classification of P-cells into the fast and slow types.

Animals↗