Search PubMed⌕ Search

Biomedical subjects

Y Kanda

Publications and source records attributed to Y Kanda.

At least 253 records · Page 14Linked to original sources
PubMed1983

Primary malignant melanoma of the esophagus.

The case of a 54-year-old man with primary malignant melanoma of the esophagus is described. The results of morphologic examination are presented, and the histogenesis of the tumor and the classification of melanomas are briefly discussed. Histologic examination suggested that this was a case of primary malignant melanoma of the esophagus arising from melanosis of the esophageal mucosa. Like melanomas from the oral mucosa, vagina, anus, and vulva, the tumor had lentiginous radial components.

Esophageal Neoplasms↗
PubMed1982

Sulfonated poly(vinylidene fluoride) as a biomaterial: immobilization of urokinase and biocompatibility.

The adsorption of urokinase (UK) on sulfonated poly(vinylidene fluoride) (PVDF) films was examined. The amount of adsorbed UK on sulfonated PVDF films increased linearly with the degree of the ion exchange capacity (IEC) of sulfonated film. Moderately sulfonated PVDF film (IEC = 0.25 meq/g) adsorbed 3 IU/cm2 UK, and highly sulfonated film (IEC = 0.54 meq/g) adsorbed 5 IU/cm2 UK. All UK-immobilized PVDF films were active for ten weeks. The presence of the sulfonated films in the culture of rat lymphocytes did not result in any change of their viability. The implant of the film (IEC greater than 0.48 meq/g) into the subcutaneous layer of rats resulted in the cell infiltration composed of lymphocytes and plasma cells or the blastogenesis within the surrounding tissues of the implant and the regional lymph nodes. On the contrary, the implant of the films (IEC less than 0.27 meq/g) did not exert any visible changes, indicating that the lightly sulfonated films may be applicable in the sense of biocompatibility in vivo.

Animals↗
PubMed1982

[Enzyme immunoassay of CEA using monoclonal antibody].

Carcinoembryonic antigen (CEA) is important as one of the tumor markers, and enzyme-immunoassay using monoclonal anti-CEA, which is based on the Sandwich method and unnecessary for the treatment of CEA-extract from serum, was tried in this study. The standard curve obtained from this assay showed lineality on low CEA level. Sensitivity could allow to detect CEA below 5 ng/ml of CEA. Correlation between radioimmunoassay and this EIA was not found in especially high CEA-concentration. Reproducibility respect of Intra-assay and Inter-assay had good results. CEA value yielded by dilution of sample serum coincided with nearly expected value; this result indicated that dilution test was effective. CEA value determined by the assay to be necessary for treatment of extract was higher than that by the assay without treatment. Though the number of test samples used for assay of CEA in serum from various diseases were small, we considered it would be appropriate to set up a normal value range in 0.44-3.16 ng/ml (mean +/- 2 SD) and cut off value at 3.9 ng/ml (mean +/- 3 SD). We have been interested in cancer-specificity on monoclonal antibody, but we could not so for evaluate effects of the assay using monoclonal antibody.

Antibodies, Monoclonal↗
PubMed1982

Determination of d-methamphetamine in urine after administration of d- or dl-methamphetamine to rats by radioimmunoassay using optically sensitive antiserum.

A radioimmunoassay was developed for the determination of d-methamphetamine in urine. Antiserum to d-methamphetamine was prepared in rabbits by immunization with d-N-4-aminobutylmethamphetamine conjugated with bovine serum albumin. d-1-[3H]-Methamphetamine was used as a labeled compound for radioimmunoassay. The specificity of the antibody against d-methamphetamine was determined by cross-reaction studies with optical isomers of methamphetamine and its analogs. The antibody was specific for d-methamphetamine and exhibited no significant cross-reaction with the l-isomers. This stereoselective assay was applied to determination of d-methamphetamine excreted in urine after oral administration of d- or dl-methamphetamine to rats.

Animals↗
PubMed1979

[Basic fetoprotein].

Explore the source record for details and available documents.

Carcinoembryonic Antigen↗