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Biomedical subjects

Y Inoue

Publications and source records attributed to Y Inoue.

At least 1,621 records · Page 90Linked to original sources
PubMed1988

[Hyperthermia adjunct to surgery in the treatment of scirrhous carcinoma of the stomach].

In approximately 80% of patients with scirrhous carcinoma of the stomach, recurrence of cancers occurs even after potentially curative resection, and recurrence most frequently occurs in the form of peritoneal metastasis. Such recurrence may be attributable to possible intraperitoneal dissemination of malignant cells already present at the time of surgery. We performed intraoperative peritoneal cytology on patients with scirrhous carcinoma of the stomach. Free cancer cells were demonstrated in the Douglas cavity in 16 of 32 (50%) patients who underwent potentially curative gastrectomy. The postoperative 5-year survival rate was 23% in patients without detectable free cancer cells in the peritoneal cavity, compared with only 9% in patients with microscopic evidence of intraperitoneal free cancer cells. Therefore, we have applied hyperthermic continuous peritoneal perfusion (CHPP) on patients with scirrhous carcinoma of the stomach in order to develop a surgical adjuvant therapy effective for the prevention of recurrence of peritoneal involvement. The results obtained so far from our study have shown an increased 3-year survival rate of patients undergoing potentially curative gastrectomy, but no improvement of therapeutic outcome in terms of postoperative 5-year survival.

Adenocarcinoma, Scirrhous↗
PubMed1988

[Hepatic arterial chemotherapy combined with hyperthermia or arterial embolization in unresectable liver tumor].

Fifty-four patients with unresectable malignant liver tumors (14 of hepatocellular carcinoma, 40 of metastasis to the liver from gastric or colo-rectal cancer) were treated with intra-hepato-arterial (IHA) injections of cis-diamminedichloroplatinum (II) (CDDP) plus 5-fluorouracil (5-FU). In 32 of the patients, the liver tumors were detected synchronously with the diagnosis of the primary cancers, which were resected palliatively. Therapeutic schedules consisted of bolus injections of CDDP (50 mg/body/week) and 5-FU (250 mg/body/day) [Regimen I], and CDDP (50 mg/body/10-14 days) and 5-FU (100 mg/body/day) [Regimen II]. In 48 patients treated with IHA chemotherapy only, a partial response (PR) was obtained in 6 of 14 (43%) evaluable patients for Regimen I and in 11 of 30 (37%) patients for Regimen II. The dose-limiting factor for treatment with CDDP was bone marrow toxicity, but this toxicity was remarkably alleviated in Regimen II without any decrease in antitumor effectiveness. In 13 patients, other modalities, such as total-body hyperthermia (4 patients), radiofrequency capacitive local hyperthermia (5), and temporary arterial embolization (4), were combined with IHA chemotherapy. PR was obtained in 7 of 13 (54%) patients with the combined therapy. This combined therapy was efficacious in 7 patients in whom no desired results were obtained by IHA chemotherapy only. The survival rate was 50% at 12 months. IHA chemotherapy with CDDP plus 5-FU, especially when according to Regimen II, appears to be a strongly recommended strategy for treatment of unresected primary or metastatic liver tumor. Further, addition of the hyperthermia or the arterial embolization might enhance the antitumor effect of IHA chemotherapy.

Aged↗
PubMed1988

[Nutritional assessments in the long-term survivors following massive resection of the small intestine].

Nutritional assessments were measured in the sixteen long-term survivors who had undergone a massive resection of more than two-thirds of the small intestine or less than 170 cm of the remaining small intestine. Prealbumin, retinol binding protein and zinc in serum and arm muscle circumference were significantly lower than the normal range. Serum albumin had a tendency to correlate to the length of the remaining small intestine. Nutritional risk index had a correlation with the length of the remaining small intestine. In this study, nutritional assessments in the patients with a massive resection of the small intestine indicated to be in preclinical malnutritional state. This may support that supplementary nutritional therapy is necessary for such patients. In addition, we reported a patient with sensory polyneuropathy caused by vitamin E deficiency due to short bowel syndrome. The level of vitamin E was low in his serum, 294 micrograms/dl (normal: 1004 +/- 65) and in his red blood cells, 136 micrograms/dl (normal: 176 +/- 9). His symptom was markedly decreased within two weeks after the administration of large doses of vitamin E.

Adolescent↗
PubMed1988

[Efficacy of sultamicillin fine granules in pyoderma, particularly in impetigo contagiosa].

Sultamicillin fine granules were administered orally to 21 patients with impetigo contagiosa and 1 patient with erysipelas, and its clinical efficacy and safety were assessed. The dosage was 10-30 mg/kg daily. Clinical efficacies of impetigo contagiosa were "excellent" in 20 cases and "fair" in 1 case, with an overall efficacy rate of 95%. The result of treatment in erysipelas was "good". Out of 19 strains of Staphylococcus aureus isolated from foci, 17 strains had high beta-lactamase activities. In these 17 strains, sensitivity to the drug was 2-32-fold higher than to ampicillin, and in 14 out of these 17 strains 4-8-fold higher sensitivity was noted. As side effects, mild diarrhea was seen in 2 patients, but those recovered spontaneously in 3-4 days without particular treatment.

Administration, Oral↗
PubMed1988

[Cerebral blood flow in patients with thalamic hemorrhage--Part 1: Serial changes of cerebral blood flow in conservatively treated patients].

Serial changes of cerebral blood flow (CBF) in nine patients with thalamic hemorrhage are studied. Measurement of CBF was performed in 3 times (acute, subacute and chronic stage) by the 133 Xe inhalation method using rapidly rotating single photon emission CT (SPECT, Tomomatic 64). The outcome was judged at 16 weeks from onset according to the activities of daily life. All patients divided into two groups (good group and poor group) [Result] 1. Serial changes in mean hemispheric CBF (mCBF) of both hematoma and nonhematoma side between good group and poor group. Between two groups, the significant difference was observed only in hematoma side was 77% CBF in acute stage and it was gradually improved in subacute stage. mCBF of nonhematoma side was normal value in all stage. In poor group, mCBF of hematoma side was 64% CBF in acute stage and it was slightly improved in chronic stage (70% CBF). Slice 2 mCBF of nonhematoma side was 69% CBF in acute stage and it was improved in subacute (74% CBF) and chronic (78% CBF) stage. 2. Serial changes in regional CBF (rCBF)--H (hematoma area).A (anterior area of hematoma).L (lateral area of hematoma).P (posterior area of hematoma) of hematoma side between good group and poor group. Between two groups, the significant differences were observed in rCBF-H.L.P on subacute stage and rCBF-P on chronic stage. Serial changes in rCBF were similar to those in slice 2 mCBF of hematoma side. 3. Serial changes in rCBF-H.A.L.P of nonhematoma side between good group and poor group.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗