Search PubMed⌕ Search

Biomedical subjects

Y Inoue

Publications and source records attributed to Y Inoue.

At least 1,009 records · Page 56Linked to original sources
PubMed1995

[A case of chylothorax caused by mesenteric panniculitis].

A 76-year-old female was referred to our hospital for examination of milky pleural effusion. We diagnosed her illness as chylothorax because of the high concentration of triglyceride in the effusion. There was neither obstruction nor damage of the thoracic duct. Systemic evaluation disclosed an abdominal mass in the umbilical region. Fasting with intravenous hyperalimentation followed by pleurodesis with minocycline successfully eliminated the effusion. On the other hand, the abdominal mass was diagnosed as mesenteric panniculitis by open biopsy. Since she also had chylous ascites, the tumor could have obstructed the intestinal lymphatics. Chylothorax was probably caused by damage to collateral lymph circulation.

Aged↗
PubMed1995

Ocular resurfacing and alloepithelial rejection in a murine keratoepithelioplasty model.

PURPOSE: To determine definitively the epithelial origin of corneal resurfacing and to elucidate the immunologic mechanisms of epithelial rejection in a murine keratoepithelioplasty (KEP) model. METHODS: After corneal epithelial removal and peritomy, donor corneal lenticules were grafted around the limbus (KEP procedure). The process of corneal reepithelialization was observed with 0.25% methylene blue staining. The origin of the renewed epithelium was determined by immunofluorescence. Syngeneic corneal lenticules were grafted to BALB/c mice. C3H/He, C57BL/6, BALB.K, DBA/2, and B10.D2 allogeneic corneal lenticules were grafted to BALB/c mice, and A.SW and A.TL allogeneic corneal lenticules were grafted to A.TH mice. Alloepithelial rejection was evaluated on the basis of clinical findings and histologic changes in grafted corneas. RESULTS: All KEP grafts were reepithelialized entirely at 3 days after surgery. The renewed epithelium proved to be derived from the lenticules in BALB/c eyes receiving C3H/He lenticules. In syngeneic grafts 5 days after KEP, the cornea recovered clarity and smoothness, which persisted to the end of the study. After complete reepithelialization, all allogeneic grafts also experienced a short duration of clear cornea. Then followed four characteristic phases of inflammatory epithelial response: initial phase, acute phase, chronic phase, and rejected phase. Histologic examination confirmed the progress and severity of inflammatory response. The mean onset times of initial phase in assorted grafts with mismatched histocompatibility antigens were: 7.9 +/- 1.8 days for both major and minor disparity grafts, 9.5 +/- 3.8 days for major disparity grafts, 18.2 +/- 5.5 days for major histocompatibility class I disparity grafts, 25.6 +/- 7.2 days for major histocompatibility class II disparity grafts, and 9.2 +/- 2.2 days for multiple minor disparity grafts. CONCLUSIONS: In donor corneal lenticule grafting to host eyes with corneal epithelium removed and conjunctival peritomy, the ocular surface was reepithelialized by lenticule-derived epithelium. Alloepithelial rejection in this model displayed characteristic manifestations and well-defined processes, enabling easy and precise evaluation of onset and intensity of graft rejection. Both major and minor histocompatibility antigens are related to corneal epithelial rejection.

Animals↗
PubMed1995

[Small cell lung cancer that appeared as a strange shape on chest X-ray films].

A 70-year-old man was admitted for diagnosis of an abnormal shadow on chest X-ray film. Chest X-ray films and chest tomograms showed a club-like shadow close to the pulmonary artery. The tumor was diagnosed as a small cell lung cancer, after transbronchial biopsy. The patient underwent chemotherapy and radiation therapy. This patient had small cell lung cancer that appeared on chest X-ray films to have a strange shape.

Aged↗
PubMed1995

Central giant cell granuloma of the temporal bone.

We present two cases of central giant cell granuloma in the temporal bone. CT showed an enhancing tumor causing a smoothly margined temporal squamosa and floor of the middle fossa. External carotid angiograms showed tumor stain mainly supplied by the temporal branches of the internal maxillary artery. In one case, MR images showed a hypointense mass on both T1- and T2-weighted images that was thought to reflect the pathologic character of this lesion.

Adult↗
PubMed1995

[Therapeutic effect of a mineralocorticoid in patients with hyponatremia of central origin].

Patients with hyponatremia of central origin were treated with a mineralocorticoid, and the therapeutic effect assessed. The subjects of this study were 14 patients (5 with subarachnoid hemorrhage, 2 with hypertensive intracerebral hemorrhage and 7 with head injury) who developed hyponatremia as a complication during their hospital stay for treatment of their intracranial lesions between March 1993 and April 1994. Hyponatremia of central origin was defined as serum Na+ levels below 135 mEq/l for at least two consecutive days with no other discernible etiology. The mineralocorticoid used was fludrocortisone acetate, and as a rule administration was started the day after the onset of hyponatremia. The mean interval until the onset of hyponatremia was 7.5 days, and the mean minimum serum sodium level was 125.7 mEq/l. The dose of fludrocortisone was 0.3 congruent to 0.6 mg/day, the mean period of administration 5.8 days, and route was via a stomach tube in 3 cases and by mouth in 11 cases. The therapeutic effect was good (improvement within 5 days) in 11 cases and fair (improvement in 5 to 8 days) in 3 cases. None of the patients manifested side effects. All of the patients had lower urinary sodium excretion than before administration, with the mean rate of decrease of 66.9%. Mineralocorticoids, which suppress natriuresis, are safe and effective in the treatment of hyponatremia of central origin. It appears that mineralocorticoid therapy may be aggressively tried in severe cases in which NaCl loading is ineffective.

Adult↗
PubMed1995

[Effect of nicardipine at different dose levels on arterial portography].

Portography via the superior mesenteric artery (SMA) with preinjection of nicardipine (NCR) into the SMA as a vasodilator at doses of 1.0 mg, 1/4 mg, 1/16 mg or 1/64 mg was compared with control portography without NCR in 30 patients. Mesenteric blood flow and portal enhancement correlated with dose levels of NCR. At least 1/4 mg of NCR was needed in arterial portography adequately to shorten the time between portal visualization and the injection of contrast medium, and to obtain well-contrasted portography without reflux of contrast medium into the aorta.

Dose-Response Relationship, Drug↗
PubMed1995

[A case of spontaneous rupture of the stomach].

We experienced a case of rupture of the stomach which was a 80-year-old female, and had suffered from vomiting after lunch followed by abdominal pain and distention. Physical examination revealed muscle guarding and radiography depicted massive free gas in the abdominal cavity. At laparotomy, a rupture was located close by the anterior wall of the greater curvature of the stomach. There was no evidence of ulceration, tumorigenesis, or traumatic history. The operation consisted of debridement around the rupture site and subsequent closure. The rupture was considered to have occurred at a fragile site due to circulatory disturbance of the gastric wall.

Abdomen, Acute↗
PubMed1995

[Prognostic factors in uterine cervical and corpus cancer].

We have studied the prognostic factors for cancer of uterine cervix and corpus. Prognostic factors for cervical cancer include clinical stage, histological type, pelvic and paraaortic lymph node metastasis and CPL classification of carcinoma. Prognostic factors for cancer of uterine corpus are concerned with clinical stage, histological type and histological differentiation, muscle invasion, lymph node metastasis, perineal washing cytology and so forth. The clinical stage of course, reflects the prognosis. Although one of the important prognostic factors is lymph no metastasis, there may be recurrence in patients with a poor prognosis in cases in which lymph node metastasis has not been observed. In order to distinguish such cases and to improve their prognosis, it is important to provide treatment individually but combined chemotherapy or radiation therapy, for example, with efforts to detect various prognostic factors.

Female↗
PubMed1995

[Subacute subdural hematoma: findings in CT, MRI and operations and review of onset mechanism].

Subacute subdural hematoma was investigated in terms of findings in CT, MRI and operations and of onset mechanism. The subjects were 7 cases of subacute subdural hematoma in which CT and MRI were performed during the past 5 year period. Subacute subdural hematoma here was defined as a nonoperated case with acute subdural hematoma, accompanied by subacute exacerbation 1-3 weeks after head trauma. The time from the injury to the onset averaged 13.7 days. CT revealed mixed density in 4 cases, low density in 3 cases and cerebral atrophy in all cases, with increasing mass sign due to the enlarged low density area. MRI revealed mixed intensity in 5 cases and high intensity in 2 cases, with increasing mass sign due to the enlarged high intensity area. Operation disclosed the outer membrane of the hematoma only in 1 case, but the inner membrane could not be identified in any case. Analysis of the hematoma contents showed a low hemoglobin concentrations and a high level of methemoglobin. Lack of outer membrane in cases with subacute subdural hematoma suggests that this is a different disease entity from chronic subdural hematoma. It is surmised that subacute subdural hematoma is the result of subdural effusion in the subacute stage, because, judging from the findings of CT and MRI each performed over time, cerebrospinal fluid is considered accountable for the increase in the mass sign.

Aged↗
PubMed1995

[Intra-ocular pressure dynamics and visual field index in normal tension glaucoma].

A variety of visual field indices were studied with Octopus peridata with the use of Octopus 201 and its examination program No. 31 in 31 eyes of 31 normal tension glaucoma (NTG) cases that showed mild to moderate degree of glaucomatous visual field defects. Twelve eyes of 12 normal volunteers served as the controls. On the basis of the results of clinical tests for intra-ocular pressure (IOP) dynamics including C-value, diurnal variation of IOP and IOP rise after the water drinking test, 31 NTG eyes were divided into 17 positive response eyes and 14 negative response eyes by the clinical tests. Though significant difference (p < .0001) of the value in visual field indices was found between NTG eyes and control eyes, no significant difference was observed between positive and negative response eyes of NTG. The value of global short-term fluctuation in positive response eyes (2.1 +/- 0.9 dB), however, appeared to be significantly (p < .004) greater than that in negative response eyes (1.3 +/- 0.4 dB) and control eyes (1.3 +/- 0.4 dB).

Adult↗
PubMed1995

[Reproducibility of the topographic parameters of the optic disk with the scanning laser tomograph].

The scanning laser tomograph was used to measure the optic disk topography in the left eye of five normal volunteers and five open angle glaucoma patients during the same day. We studied the reproducibility of 7 topographic parameters with the coefficient of variation (CV) and coefficient of reliability (CR) from topographic images of the scanning laser tomograph. The mean CV of the topographic parameters was 8.1 +/- 3.3% (range: 5.3-15.0%) and the mean CR of the topographic parameters was 91.8 +/- 7.6% (range: 78.6-98.4%) in normal eyes. In glaucoma eyes, the mean CV was 7.2 +/- 3.7% (range: 4.4-15.0%) and the mean CR was 84.8 +/- 7.5% (range: 73.4-95.3%), respectively. The results showed that the scanning laser tomograph has good reproducibility for clinical use in optic disk measurements.

Adult↗
PubMed1995

[Late phase II trial of RP56976 (Docetaxel) in patients with non-small-cell lung cancer].

A late phase II trial on RP 56976 (Docetaxel) was carried out against stage IIIB or IV non-resectable non-small cell lung cancer as a multicenter cooperative trial. Of 78 enrolled patients, seventy five patients were eligible and 71 were evaluable for the response. The overall response rate was 19.7% (14/71): 27.9% (12/48) of patients with adenocarcinoma and 10.0% (2/20) of patients with squamous cell carcinoma responded to docetaxel. The response rate was 15.0% (3/20) in patients with stage III B disease and 21.6% (11/51) in patients with stage IV disease. Leukopenia (neutropenia) occurred frequently, but most tended to recover in a short period of time. Other adverse reactions included nausea/vomiting, anorexia, general malaise, alopecia, all of which were not severe. Severe hypersensitivity reactions occurred in 2 patients (2.7%). The results seemed to show usefulness of docetaxel for the treatment of patients with non-small cell lung cancer.

Adenocarcinoma↗
PubMed1995

[Development of infection with Aspergillus flavus in woman being treated for allergic pulmonary Aspergillosis caused by Aspergillus fumigatus].

A 36-year-old woman who raised plants in a large greenhouse came to our hospital because of a cough and purulent sputum. A chest X-ray film showed infiltrative shadows in the left middle lung field. Aspergillus fumigatus was isolated from samples of sputum and bronchoalveolar lavage fluid obtained from the left B5. Biopsy specimens revealed hyphae elements of aspergillus species and eosinophils in a plug of viscous material. Also, eosinophils and lymphocytes had infiltrated through bronchial epithelium without aspergillus species. She was given a diagnosis of allergic aspergillosis caused by Aspergillus fumigatus. Fluconazole was given and her symptoms and infiltrative shadows improved. Seventy days after treatment with fluconazole began, her symptoms recurred along with an abnormal shadow in the left upper lung field on a chest x-ray film. Aspergillus flavus, but not Aspergillus fumigatus, was isolated from samples of sputum and bronchoalveolar lavage fluid obtained from the left lung (S1+2). Biopsy specimens of the lung showed eosinophilic pneumonia. She was treated with itraconazole and her symptoms and abnormal radiographic shadows disappeared. She had no asthmatic attack or central bronchiectasis du ring the illness. This was a case of allergic pulmonary aspergillosis without asthmatic symptoms. It is interesting that one species of aspergillus was replaced by another during treatment.

Adult↗
PubMed1995

Quantitative comparison of human computer interaction for direct prescription entry systems.

An objective and quantitative method is described for evaluating human-computer interaction (interface) in a direct prescription entry system. This method is based on a GOMS model and represented by a tree structure. Three different interfaces at university hospitals were compared by this evaluation method, and the differences among them were measured.

Clinical Pharmacy Information Systems↗
PubMed1995

Reorganization of the information technology program at a United States medical school: is there a lesson for academic medical informatics in Japan?

Reorganization of the information technology program at Baylor College of Medicine commenced with the goal of obtaining a client-focused organization instead of a classically departmental structure. Legacy organizations independently established by request or serendipity had gaps and overlaps in services and could no longer respond to new issues, such as integration of several hospitals, resource sharing of health care delivery, administration of a shared library, and an academic informatics program. The renewal of the information technology program has led to departments of Telecommunications, Enterprise Services, Client Services, and Medical Informatics, and has also allowed cross-departmental projects led by a technology architect. In contrast with that of Baylor, the approach of the Yamaguchi University School of Medicine in Japan may be construed as economic efficiency at the cost of client services. Effective client services by friendly and efficient staff groups is the most important factor for an academic information technology program, if the goal is to reorganize in anticipation of future challenges to the medical center.

Computer Systems↗