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Biomedical subjects

Y Iguchi

Publications and source records attributed to Y Iguchi.

At least 73 records · Page 4Linked to original sources
PubMed1991

Synthesis and nonthrombogenicity of polyetherurethaneurea film grafted with poly(sodium vinyl sulfonate).

Synthesis of nonthrombogenic materials without using biologically active substances was explored. Poly(sodium vinyl sulfonate) is a water-soluble synthetic polymer and activates antithrombin III to exert nonthrombogenicity that was dependent on the molecular weight. Polyetherurethaneurea film was plasma-treated and graft-polymerized with sodium vinyl sulfonate. The graft film showed excellent in vitro and ex vivo nonthrombogenicity by suppressing interactions with plasma proteins and platelets as well as by inactivating blood-clotting factors.

Adsorption↗
PubMed1990

[A case of idiopathic esophageal perforation (Boerhaave's syndrome)].

76 year-old man was transferred to emergency room because of severe epigastralgia and dyspnea. He was well until 5 hours before admission, when he suddenly felt severe epigastralgia followed by vomiting. He was found to be in warm shock state. Chest X-ray film showed dilation of mediastinum, pneumo mediastinum, left pleural effusion and subcutaneous emphysema, which were consistent with esophageal perforation. Esophageal contrast study was diagnostic. Emergency operation was performed in which rupture of the lowest esophagus causing remarkable mediastinitis and pleuritis was observed. Esophageal tear was primarily closed and chest drains were placed. Despite severe post-operative complications, he was discharged with recovery 5 months later.

Aged↗
PubMed1989

Development of percutaneous intramuscular electrode for multichannel FES system.

A percutaneous intramuscular electrode was developed for controlling paralyzed extremities by FES. The electrode was made of a Teflon-coated 19 strand rope wound from ultrafine SUS 316L stainless steel wires and was helically coiled for giving high flexibility. Because of low percentages of electrode failure in the body, stable and reliable FES was achieved for a long time.

Electric Stimulation Therapy↗
PubMed1987

Hairy cell leukemia in Japanese patients: a study with monoclonal antibodies.

Using a panel of monoclonal antibodies and three anti-hairy cell sera (alpha HC1 and alpha HC2 of Posnett and 4B122 prepared by the authors), hairy cells were phenotyped on frozen sections of cell pellets from blood and spleen of 11 Japanese patients with hairy cell leukemia (HCL). The results were quite similar to those reported for HCL of non-Japanese patients inasmuch as hairy cells in the majority of these patients were B1+, B2-, FMC7+, and IL-2R1+. However, they were more often than not J5+, Leu-1+, alpha HC1-, alpha HC2-, and 4B122+ in contrast to the pattern reported for non-Japanese patients. In conclusion, HCL in the Japanese constitutes a special variant of HCL because of its rareness, unusual immunophenotype, and atypical clinicohematologic features.

Aged↗
PubMed1986

Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase.

A prostaglandin F (PGF) synthase was recently purified from bovine lung that catalyzed the reduction of both PGH2 and PGD2 but at different active sites on the enzyme. In view of the recent finding that PGD2 is stereospecifically reduced to a unique biologically active compound, (5Z, 13E)-(15S)-9 alpha, 11 beta, 15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-PGF2 or 11-epi-PGF2 alpha), by a human liver cytosolic enzyme, detailed characterization of the products formed from PGH2 and PGD2 by the bovine lung PGF synthase was carried out. Chromatographic characteristics of the products formed and stereochemical analysis procedures using mass spectrometry indicated that the enzyme stereospecifically reduces PGH2 to PGF2 alpha, whereas PGD2 is stereospecifically converted to 9 alpha,11 beta-PGF2. The finding that this enzyme catalyzes the formation of both C-11 hydroxy epimers of PGF2, albeit from different substrates, is of interest in that these two compounds may exert different biological actions.

Animals↗
PubMed1986

Kimura's disease and its relation to angiolymphoid hyperplasia with eosinophilia: report of three cases and review of the literature.

Kimura's disease, eosinophilic granuloma of soft tissues, is a chronic inflammatory condition and appears as subcutaneous tumor-like nodules in the head and neck regions. Histopathologically, it is characterized by the presence of lymphoid follicles, marked infiltration of eosinophils, fibrosis and vascular proliferation. This disease occurring in the orofacial region is relatively rare, only 14 cases having been previously reported. We describe 3 additional cases of Kimura's disease and discuss these in relation to angiolymphoid hyperplasia with eosinophilia.

Adolescent↗
PubMed1985

[Effects of human calcitonin on the response to noxious stimuli and morphine-antinociception].

Effects of human calcitonin (HCT) on the responses of mice and rats to noxious stimuli of various types and morphine-antinociception in the mice tail-pinch method were studied as compared with procine calcitonin (PCT). I.c.v. administration of HCT (0.007-0.071 mg/mouse) delayed response time to tail-pinch stimuli and suppressed acetic acid writhing dose-relatedly. PCT (0.5-3 U/mouse, i.c.v.) exerted a dose-related antinociceptive effect in the tail-pinch and acetic acid writhing methods. The antinociceptive effect was also produced by s.c. administration of HCT (0.071-7.1 mg/kg) and PCT (10-1000 U/kg) in the tail-pinch and writhing methods, while the antinociceptive effect was not detected by the tail-flick method following i.c.v. and s.c. administration of HCT and PCT. Increase in response threshold in the hind paw pressure test was produced by 0.071-7.1 mg/kg, s.c. of HCT and 10-1000 U/kg, s.c. of PCT in rats. Inhibition of writhing due to i.c.v. administration of HCT and PCT was not antagonized by naloxone. Pre-drug control response time to tail-pinch stimuli tended to be shortened after 7-14 days of s.c. treatment with CT, especially with PCT. Pretreatment with HCT and PCT exerted no obvious influence on their acute effects. Morphine-antinociception in the tail-pinch method tended to be potentiated by single s.c. dose of HCT and to be decreased by 14 days chronic s.c. treatment with HCT. The role of calcium in HCT action was discussed.

Analgesics↗
PubMed1985

[The role of the pituitary in the development of electroacupuncture analgesia in rats].

In order to investigate the involvement of pituitary beta-endorphin in electroacupuncture analgesia (EAA), the effects of hypophysectomy, dexamethasone (Dex) and adrenalectomy on the analgesia and the increase in plasma corticosterone (Cort) and ACTH levels produced by electroacupuncture (EA) were studied in male SD rats. In saline-treated and Dex-treated rats, plasma Cort levels were correlated with plasma ACTH levels. In non-treated rats, the time course of EA-induced increase in pain threshold was similar to that of EA-induced elevation of plasma Cort levels. In the hypophysectomized rats, EAA was significantly reduced and the EA-induced increase in plasma Cort was also abolished. Single administration of a large dose of Dex tended to reduce EAA and significantly reduced the EA-induced increase in plasma Cort and ACTH. Further suppression of pituitary functions by 4 days-treatment with Dex resulted in further reduction of EAA and the EA-induced increase in plasma Cort and ACTH. On the other hand, hind-paw pressure test without EA produced an increase in plasma Cort and ACTH to the same extent as that produced by EA and produced no analgesia. In the adrenalectomized rats, EAA was reduced, and the plasma ACTH level, which was sixteen times higher than that of nonoperated rats, was further elevated 2-fold higher by EA. No correlation between plasma ACTH levels and the increase in pain thresholds was observed in individual rats of the saline-treated and Dex-treated groups. Control pain thresholds were not influenced by hypophysectomy, Dex or adrenalectomy. These results suggest that pituitary beta-endorphin may not be mainly involved in EAA.

Acupuncture Therapy↗
PubMed1985

[Effects of NRGC-lesion on the rates of the development of morphine tolerance and dependence in rats].

The development of tolerance to and dependence on morphine over 1-8 days treatment with morphine were studied with time in rats in which the nucleus reticularis gigantocellularis (NRGC), including the nucleus reticularis paragigantocellularis, were electrically destructed. The NRGC of SD male rats was bilaterally lesioned (DC, 0.5 mA, 40 sec), and morphine analgesia was estimated by the tail flick method. Morphine analgesia in NRGC-destructed rats (D-rat) was reduced to about 50% of that in sham-operated rats (S-rat). The dose of morphine to produce equi-analgesia increased 2-21.8 times during 1-8 days treatment with morphine in S-rat. Throughout this period, ratios of the equi-analgesic dose in D-rat to that in S-rat were almost the same, i.e., the rate of tolerance development to morphine analgesia in D-rat was to the same degree as that in S-rat. Administration of naloxone after 1-6 days treatment with morphine elicited body weight loss and increase in plasma corticosterone (Pcs), degrees of which were dependent on the dose of naloxone or the period of morphine treatment. No difference in these abstinence signs were detected between S- and D-rat, i.e., the rate of development of dependence on morphine in D-rat was to the same degree as that in S-rat. These results suggest that the NRGC participates in the development of morphine analgesia, but does not participate in the development of tolerance to and dependence on morphine.

Animals↗
PubMed1985

[Effects of electroacupuncture on beta-endorphin contents in rats].

Effects of electroacupuncture (EA) on pain threshold and beta-endorphin (beta-End) contents in plasma, pituitary (Pit), hypothalamus (Hyp) and cerebrospinal fluid (CSF) were studied in nontreated, dexamethasone (Dex) treated and adrenalectomized (Adrex) male SD rats by the use of specific determination of rat beta-End (combination of HPLC and RIA). EA increased pain threshold and plasma beta-End with no effect on beta-End contents in Pit, Hyp and CSF. Dex did not affect control pain threshold, but tended to reduce EA-induced increase in pain threshold (EA-analgesia, EAA) and EA-induced increase in plasma beta-End. Adrex increased plasma beta-End without change in control pain threshold. Adrex tended to reduce EAA, but a tendency of further increase in plasma beta-End was observed after addition of EA. Adrex increased Pit beta-End, but no further change in Pit beta-End was observed after addition of EA. A positive correlation between plasma beta-End and plasma ACTH was observed in nontreated, Dex treated and Adrex rats. No correlation between plasma beta-End and potency of EAA was observed in nontreated, Dex treated and Adrex rats. The hind-paw pressure test without EA increased plasma beta-End to the same degree as that produced by EA, and it produced no analgesia. These results suggest that Pit beta-End may not be mainly involved in the development of EAA.

Acupuncture Therapy↗