Biomedical subjects

Y Horiuchi

Publications and source records attributed to Y Horiuchi.

330 records · Page 19Linked to original sources

PubMedDate not supplied

Magnetic resonance imaging of suprascapular nerve palsy.

In magnetic resonance imaging of peripheral nerve palsy, changes of signal intensity are often found in paralyzed muscles. The purpose of this report is to clarify the relation between magnetic resonance imaging findings and clinical examination in suprascapular nerve palsy. The subjects were 12 patients with suprascapular nerve palsy who underwent magnetic resonance imaging examinations. In 9 of 12 cases ganglion cysts were found at the spinoglenoid notches. On T1-weighted images the signal intensity of infraspinatus muscle was high in four cases but normal in the supraspinatus muscle in all cases. On T2-weighted images the signal intensity of infraspinatus muscle was high in six cases, and that for supraspinatus muscle was high in one case. In two cases the high intensity of palsied muscles became normal after the palsy recovered. Magnetic resonance imaging is a useful examination of peripheral nerve palsy not only for the detection of ganglion cysts but also for assessing the stage of paralysis.

Adult↗

PubMedDate not supplied

Imaging of various surface properties of fluorescently labelled phospholipid Langmuir-Blodgett films with a combined scanning probe microscope.

We present results of phase separation of a single-component system of 1,2-dihexadecanoyl-sn-glycero-3-phospho-[N-(4-nitrobenz)-2-oxa-1,3-diazolyl]ethanolamine in which a liquid-condensed (LC) phase co-exists with a liquid-expanded (LE) phase. Domain formation in the co-existence region was studied using a newly developed combined scanning near-field optical microscope-atomic force microscope (SNOM-AFM). We demonstrate for the first time that the topographic, friction, fluorescence and surface potential distributions for a phase-separated single-component Langmuir-Blodgett film between the LE and LC phases can be simultaneously observed using the SNOM-AFM with a thin-step etched optical fibre probe.

Fluorescent Dyes↗

PubMedDate not supplied

FK506 (tacrolimus) inhibition of intracellular production and enhancement of interleukin 1alpha through glucocorticoid application to chemically treated human keratinocytes.

PURPOSE: Production of the proinflammatory cytokine interleukin (IL) 1alpha, which is stored in keratinocytes (KCs) and is multifunctional, may be enhanced by glucocorticoids. A study was made to confirm whether immunosuppressants such as the macrocyclic lactone FK506 (tacrolimus) possibly serve to modulate glucocorticoid- stimulated IL-1alpha production from chemically treated KCs. METHODS: Using cultured human KCs, the effects of FK506 on the production of IL-1alpha treated with chemicals (trinitrobenzene sulfonic acid sodium salt, TNBS) plus hydrocortisone were analyzed by ELISA and mRNA expression of IL-1alpha using RT-PCR. RESULTS: Intracellular IL-1alpha in TNBS-treated human KCs was increased with a low concentration of 10(-10)M of hydrocortisone. Further FK506 application inhibited significantly this increased production. The mRNA expression of IL-1alpha at various concentrations of chemicals was not remarkably different. CONCLUSIONS: FK506may control the increase in IL-1alpha with glucocorticoid in KCs, suggesting FK506 to suppress harmful effects of glucocorticoids such as steroid rosacea.

Anti-Inflammatory Agents↗

PubMedDate not supplied

An analysis of turn-taking and backchannels based on prosodic and syntactic features in Japanese map task dialogs.

In this study, we investigate syntactic and prosodic features of the speaker's speech at points where turn-taking and backchannels occur, on the basis of our analysis of Japanese spontaneous dialogs. Specifically, we focus on features such as part of speech, duration, F0 contour pattern, relative height of the peak F0, energy trajectory pattern, and relative height of the peak energy at the final part of speech segments. We examine, first, the relationship between turn-taking/backchannels and each feature of speech segments independently, showing that the features examined in this study are all related to turn-taking or backchannels and that the way they correlate is fairly consistent with previous studies. Next, we explore the inter-relationship among the features with respect to turn-taking and backchannels. We show that in both turn-taking and backchannels, (1) some instances of syntactic features make extremely strong contributions, and (2) in general, syntax has a stronger contribution than any individual prosodic feature, although the whole prosody contributes as strongly as, or even more strongly than, syntax. We also discuss some implications of our results, comparing them with previous models that have mentioned roles of syntax and prosody in turn-taking and backchannels.

Attention↗

PubMedDate not supplied

A phase II multicentric trial of S-1 combined with 24 h-infusion of cisplatin in patients with advanced gastric cancer.

BACKGROUND: The aim of this multicentric trial was to determine the clinical toxicities and antitumor effects of a chemotherapy regimen of S-1 combined with cisplatin in patients with inoperable locally or metastatic advanced gastric cancer. PATIENTS AND METHODS: Forty-two patients were entered into the study. S-1 (80 mg/m2) was administered orally daily for 14 consecutive days and 24-h infusion of cisplatin (70 mg/m2) was administered on day 8 of every 28-day cycle. RESULTS: The overall response rate was 50% and complete response rate was 5%. The most common adverse event was leucopenia, which occurred with grade 3 in 7 patients (16.6%) and grade 4 in 2 patients (4.8%). Non-hematological adverse events were generally mild. The median survival time was 342 days. The 2-year survival rate was 22.9%. CONCLUSION: This combination chemotherapy is active, convenient and well tolerated in patients with high-grade advanced gastric cancer.

Adult↗

PubMedDate not supplied

A gouty family with increased phosphoribosylpyrophosphate synthetase activity: case reports, familial studies, and kinetic studies of the abnormal enzyme.

Two male patients with urate overexcretion and clinical gout in a family showed activity of phosphoribosylpyrophosphate (PRPP) synthetase in erythrocyte lysates (3.1-fold) greater than that found in normal subjects. Hemolysates from 5 female persons in this family contained (2.7-fold) increased enzyme activity suggesting X-linked dominant transmission of the abnormality. Increased maximal velocity of the enzyme, aberrant protein pattern in polyacrylamide electrophoresis, and increased thermolability in purified enzyme suggested that this enzyme is a mutant one. From these findings, it was assumed that the characteristics of this enzyme were different from 4 previously reported enzymes.

Adenosine Diphosphate↗