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Biomedical subjects

Y Horiuchi

Publications and source records attributed to Y Horiuchi.

At least 325 records · Page 18Linked to original sources
PubMedDate not supplied

Clinical evaluation of D-penicillamine by multicentric double-blind comparative study in chronic rheumatoid arthritis.

In order to evaluate clinical efficacy of D-penicillamine (DP) a double-blind study was conducted by the Metalcaptase Research Group consisting of forty-one rheumatological centers in Japan. A total of 179 patients with rheumatoid arthritis (RA) was divided into two groups; one treated with 5 mg (control group) and the other with 100 mg (drug group) of DP in capsule form. The trial lasted 24 weeks. Global judgment by physicians revealed that improvement was found in 27% in the controls and 65% in the drug group. Adverse reactions occurred in 34% of the controls and 49% of the drug group. Skin rashes, taste disturbances, gastrointestinal upset and proteinuria were frequent in the drug group, but severe or fatal reactions could not be seen in this trial.

Administration, Oral↗
PubMedDate not supplied

Advancement of the insertion of the biceps brachii muscle: a technique for increasing elbow flexion force.

A new technique for increasing weak flexion force of the elbow in patients with brachial plexus injuries is reported. The concept of this procedure is to increase the moment arm of the biceps brachii muscle by moving the point of action distally. Advancement of the insertion of the biceps brachii muscle was performed with an anterior approach to the radius. The biceps tendon was stripped off the radius at its insertion. A hole was dug into the radius 2 cm distal to the original insertion. The biceps tendon was then reattached to the drill holes made in the distal edge of the initial hole with the elbow in 30 degrees of flexion. After immobilization in 70 degrees of flexion for 5 weeks, range-of-motion exercises were initiated. This procedure was applied in six cases of brachial plexus injury. Flexion force at the elbow was increased, and the initial motion of elbow flexion has become very smooth in all patients. Consequently the activities of daily living are easier to perform. This procedure is simple and involves no functional or tissue sacrifice.

Adolescent↗