Biomedical subjects
Publications and source records attributed to Y Horiguchi.
A 57-year-old woman who had sensorimotor polyneuropathy with dysgammaglobulinemia showed pea-sized tense blisters on the fingers. Histopathological features were intraepidermal multilocular bullae and degeneration of capillaries of the papillary dermis with decreased nerve components of the dermis. Clinicopathological findings indicate this case to be trophoneurotic bullae.
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The effects of a single therapeutic dose of sympathomimetics, adrenaline, ethylphenylephrine, isoprenaline and terbutaline on venous return and other peripheral vascular beds were compared in dogs subjected to controlled cardiac output. The intra-aortic administration of adrenaline (1 microgram/kg) produced increases in femoral arterial pressure (FAP), left auricular outflow (LAO) and superior vena-caval flow (S-VCF), while no significant change was observed in inferior vena-caval flow (I-VCF) and femoral venous pressure. Ethylphenylephrine (0.4 mg/kg), a selective alpha-adrenoceptor stimulant, showed almost the same pattern of change but of smaller magnitude as adrenaline, though the duration of the effect was longer. Isoprenaline (1 microgram/kg) showed decreases in FAP and LAO, and marked increases in S-VCF and I-VCF. Terbutaline (20 microgram/kg), a beta2-adrenoceptor stimulant, showed no significant effect on LAO, though other parameters changed with the same pattern produced by isoprenaline.
(1) Therapeutic effects of bronchial artery infusion (BAI) of peplomycin (PEP), a derivative of bleomycin, were examined in the 13 patients with lung cancer. The effectiveness of PEP was compared with that of 59 patients treated with mitomycin (MMC) or carboquon (CQ). (2) In all cases treated with PEP, histopathological effects revealed to be more than grade IIa of Shimosato's criteria, which were more effective than that with MMC or CQ. (3) Histopathological changes of the metastatic lymph nodes were similar to that of the main tumor. (4) In the cases treated with PEP, tumor decreased rates shown in the chest X-ray films 2 weeks after BAI were lower than that with MMC or CQ. Cavity formation in the tumor was recognized in 62% of the cases treated with PEP. (5) Low fever lasting several days after administration of BAI and GI symptoms such as nausea and vomiting were main side effects, which were mild and not so serious.
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Inhibition of secretin-stimulated pancreatic secretion by glucagon was studied in anesthetized dogs. Two external pancreatic fistulas were prepared in dogs for both simultaneous and separate collection of pancreatic juice secreted by the right and left lobes. Two series of experiments were preformed. In the first, graded doses of glucagon (2.5 to 20 micrograms/kg/hr) were administered against a background infusion of 2 CHR U/kg/hr of secretin. In the second, a constant dose of glucagon (20 micrograms/kg/hr) was given against a background infusion of secretin doubling from 1 to 8 U/kg/hr. Infusion of glucagon was started when flow rate became nearly constant, and continued for 60 minutes in each dose. Glucagon produced the dose-related reduction in flow rate and bicarbonate secretion, but not in amylase secretion. This inhibitory effect was almost the same in size between the right and left lobes. No significant change of plasma secretin was observed during glucagon infusion. Michealis-Menten analysis of the dose in slopes (Km) and similar intercepts of Y-axis (CMR). These results suggest that glucagon inhibits competitively secretin-stimulated pancreatic secretion by acting probably on the same receptor as secretin.
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A case of recurrent pancreaticopleural effusion is presented. The pleural effusion with high enzyme and protein contents resulted from a pancreatic internal fistula to the left pleural cavity. A sinus tract passing through esophageal hiatus was demonstrated by the endoscopic retrograde pancreatography (ERP). Surgical intervention afforded complete relief of abdominal pain and elimination of the pleural effusion.