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Biomedical subjects

Y Horiguchi

Publications and source records attributed to Y Horiguchi.

At least 235 records · Page 13Linked to original sources
PubMed1985

Atypical pityriasis rosea.

Six cases of pityriasis rosea with atypical morphology and distribution of the eruption are reported. The eruption did not show a typical 'Christmas-tree' arrangement, confined to the trunk and proximal parts of the extremities. However, the histology of the eruption revealed dyskeratotic cells in the epidermis and extravasated erythrocytes in the dermis, which were recently reported as rather characteristic findings of this disease. Prodromal symptoms, course and response to therapy were compatible with pityriasis rosea. Histological examination is important and helpful for the diagnosis of atypical cases.

Adolescent↗
PubMed1984

Dermatopathological studies on skin lesions of MRL mice.

The MRL-lpr/lpr(MRL/l) mouse is a new animal model for human systemic lupus erythematosus (SLE) and skin lesions with hair loss and scab formation are one of the characteristic manifestations in this mouse. We investigated the histopathology of the skin lesions in MRL/l mice and studied the related autoimmune phenomenon. Light microscopical observations revealed hyperkeratosis, acanthosis, hypergranulosis, liquefaction, vasodilation in the dermis and T-cell infiltration into the dermis at the age of 5 months (mo). Immunohistological studies showed the presence of immunoglobulins and/or complement depositions at the dermal-epidermal junction (DEJ). In some mice there was deposition of immunoglobulin at the DEJ at 2 mo and in 90%-100% of MRL/l mice at over 5 mo. Temporal relationship was present among cutaneous immunoglobulin depositions, the occurrence of anti-DNA antibodies and proteinuria. These findings suggest that MRL/l mice might provide a new aid for studying the biological mechanisms of the development of skin lesions in human SLE.

Age Factors↗
PubMed1984

Ultrastructural observations of skin lesions in MRL mice--dermoepidermal junction.

The MRL-lpr/lpr (MRL/l) mouse, a new animal model for the study of human systemic lupus erythematosus (SLE), shows characteristic skin manifestations in addition to several systemic autoimmune phenomena. The ultrastructural changes observed in the dermoepidermal junction (DEJ) and in the uppermost dermis were: infolding of the DEJ; deformities of the basal lamina--partial disappearance, thickening, hanging down, duplication, and separation from the basal cell membrane; basal laminalike dense material in the uppermost dermis and increased anchoring fibrils; particles composed of circulated half-desmosomes between the basal cells and the basal lamina, and in the uppermost dermis with or without an enclosing basal lamina; cell processes of the basal cells; and invagination of the basal lamina in the basal cells. Most of these findings were similar to the ultrastructural changes observed in the skin lesions of human SLE. The skin eruptions of MRL/l mice might be a new aid in the investigation of the pathogenesis of the skin lesions of human SLE.

Animals↗
PubMed1984

Cutaneous metastasis from papillary carcinoma of the thyroid gland. Report of two cases.

Two cases of metastatic skin tumors on the scalp appearing several years after thyroidectomy for thyroid papillary carcinoma are reported. Histologic examination of biopsy specimens from both patients revealed glandular-forming masses with intricate papillary folds in the dermis. The tumor epithelium was composed of single-layered cylindrical and cuboidal cells without atypia. Using the immunoperoxidase technic, many of the proliferating cells were shown to produce triiodothyronine (T3) and thyroglobulin (Tg).

Aged↗
PubMed1984

The ultrastructural observation of a case of lymphomatoid papulosis.

Electron microscopic studies of biopsy specimens from a patient with lymphomatoid papulosis were performed. In the epidermis, infiltrating lymphoid cells, many of which had highly convoluted nuclei, were revealed to come into close contact to increased Langerhans' cells but did not accumulate to form microabscesses. In the dermis, Langerhans' cells with rather small numbers of Birbeck granules were scattered among the thick infiltration of mononuclear cells showing close apposition with lymphoid cells. Some macrophages contacted the Langerhans' cells and lymphoid cells were also observed. On one occasion, a Langerhans' cell clinged by a lymphoid cell in the uppermost dermis was revealed to expand the cytoplasm through the ruptured basal lamina touching another lymphoid cell in the epidermis.

Aged↗
PubMed1984

Effect of ascorbic acid and some reducing agents on N-nitrosopiperidine metabolism by liver microsomes.

The effect of ascorbic acid on the oxidation of N-nitrosopiperidine by a microsomal preparation obtained from guinea-pig liver has been examined. The metabolites from the oxidation of N-nitrosopiperidine were found to be 5-hydroxypentanal (about 1.93%), N-nitroso-3-hydroxypiperidine (about 0.02%), and N-nitroso-4-hydroxypiperidine (about 0.15%). With microsomes separated from the liver of guinea-pigs pretreated with phenobarbital and 3-methylcholranthrene, the yields of N-nitroso-3-hydroxypiperidine and N-nitroso-4-hydroxypiperidine were found to decrease upon increasing the concentration of ascorbic acid in the reaction mixture. In the presence of small amounts of ascorbic acid, the yields of these compounds with untreated liver microsomes apparently increased, while the presence of larger amounts of ascorbic acid caused a decrease in the yields of these metabolites. In contrast with the yields of N-nitroso-3-hydroxypiperidine and N-nitroso-4-hydroxypiperidine, that of 5-hydroxypentanal decreased with increasing amounts of ascorbic acid.

Aldehydes↗
PubMed1984

Bullous pemphigoid-like lesions induced by phenacetin. Report of a case and an immunopathologic study.

An 84-year-old man with chronic eczema and ischemic heart disease had bullous pemphigoid-like lesions develop following the oral administration of phenacetin. The diagnosis was confirmed by routine histopathologic studies and by immunofluorescent and electron microscopy. Since rechallenge with phenacetin resulted in bulla formation, phenacetin was considered to be the causative agent. This patient showed several atypical clinical features, compared with patients with idiopathic bullous pemphigoid, including no associated erythematous macules, a positive Nikolsky's sign, painful superficial ulcers, and nonpruritic bullae. Histopathologically, there was lack of polymorphonuclear leukocyte infiltrate. The immunopathologic characteristics, however, were quite typical for those found in bullous pemphigoid. The antigenic sites for the autoantibodies from our patient were, at least in part, different from those of idiopathic bullous pemphigoid.

Administration, Oral↗
PubMed1983

Inhibition of gastric emptying by chinoform and its relation to strain differences in acute toxicity of chinoform in mice.

Significant difference in oral LD50 of chinoform in mice was observed between strains C57BL/6 and C3H/He. C57BL mice were more sensitive to oral toxicity of chinoform than C3H mice. Doses of 200 mg/kg of chinoform gave a more rapid and prolonged inhibition of gastric emptying in C57BL mice than in C3H mice. Small intestinal transit in C57BL mice was slower than that in C3H mice. The delayed gastric emptying and slow small intestinal transit in C57BL mice affected the blood levels of chinoform, and these factors may be, at least partly, responsible for the difference in the lethal toxicity of chinoform between the two strains.

Animals↗
PubMed1983

Metabolism of D-phenylalanine and its effects on concentrations of brain monoamines and amino acids in rats--a basic study on possibility of clinical use of D-phenylalanine as an antidepressant.

The effect of D-phenylalanine on the concentrations of brain catecholamines, serotonin, beta-phenylethylamine and amino acids was examined using rats injected intraperitoneally with 200 mg/kg of D-phenylalanine. The contents of these monoamines in the rat brain were not affected by the administration of D-phenylalanine. No spectacular change was observed in the concentrations of brain amino acids except phenylalanine, which increased about four times during 30-60 minutes after the injection. This increase was attributed to the administered D-phenylalanine. To confirm the finding that D-phenylalanine did not affect the content of beta-phenylethylamine, the metabolism of D-phenylalanine was examined using D-[14C]-phenylalanine. It was proven that D-phenylalanine did not convert to beta-phenylethylamine. On the basis of these findings the antidepressant effect of D-phenylalanine was critically discussed.

Amino Acids↗