Search PubMed⌕ Search

Biomedical subjects

Y Homma

Publications and source records attributed to Y Homma.

At least 343 records · Page 19Linked to original sources
PubMed1981

Different effect of (L)-fucose binding lectin on macrophage migration inhibition caused by guinea pig migration inhibitory factor and synthetic muramyl dipeptide.

(L)-Fucose binding lectin of Ulex europeus (UEA-I) was applied for the study of receptors for macrophage migration inhibitory factor (MIF) and synthetic muramyl dipeptide (MDP). The lectin was found to reduce the responsiveness of macrophages towards MIF when the cells were pretreated with the lectin. The suppressive effect of the lectin on MIF was reversed by (L)-fucose, but not by (D)-galactose, indicating that the effect of lectin is a sugar-specific phenomenon. By immunofluorescence technique the lectin appeared to be on the cell surface of the macrophages. These results suggest that the receptor for MIF and UEA-I lectin was identical or at least partially common. The lectin, however, did not prevent the responsiveness of cells toward MDP, which is known to inhibit macrophage migration just as MIF. These findings suggest that the mechanisms of the inhibitory effect on macrophage migration caused by the two substances (MIF and MDP) may be different, at least at the level of the receptors.

Acetylmuramyl-Alanyl-Isoglutamine↗
PubMed1981

Studies on pathogenicity and persistence of Propionibacterium acnes in mice.

The pathogenicity of Propionibacterium acnes was studied using immunodeficient and germ-free (GF) mice. P. acnes injected i.p. to immunocompetent (ddY and BALB/c-nu/+) and -deficient mice (CBA/N and BALB/c-nu/nu) decreased rapidly and only as small number were recovered from organs from day 7 on. The organisms injected similarly into GF-immunocompetent (GF-CF1) mice also decreased but when injected into GF-immunodeficient (GF-BALB/c-nu/nu) mice a small number persisted as late as week 4. When GF-immunocompetent (GF-ICR) mice were treated with cortisone and anti-mouse thymocyte serum, a small number of organisms were also recovered for 4 weeks after injection. Upon injection into irradiated GF-nu/nu mice, the number of viable P. acnes decreased relatively slowly and were recovered even at week 22. After oral administration a small number of P. acnes were readily detected from organs of GF-nu/nu mice but rarely from GF-nu/+ mice. The results indicate that P. acnes organisms have very low pathogenicity to mouse. However, small numbers persisted in organs of P. acnes-monoassociated immunodeficient mice. The mechanisms of this persistency of the nonpathogenic bacteria is discussed.

Animals↗
PubMed1981

Multiple cystic lesions of the lung.

A case with huge cystic disease of the lung was reported. The plain chest X-P revealed several linear shadows in the left middle lung field. Bronchography disclosed multiple cystic lesions located mainly in the left lung. There were also several small cystic lesions in the right lung. No inflammatory findings of the bronchi were found. Difficult problem concerning differential diagnosis between acquired and congenital cystic disease of the lung was discussed.

Adult↗