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Biomedical subjects

Y Hishikawa

Publications and source records attributed to Y Hishikawa.

208 records · Page 12Linked to original sources

Radiotherapy of carcinoma of the gallbladder.

Thirteen patients with carcinoma of the gallbladder were treated with radiation therapy using Cobalt-60 or 10 MV X-ray. The total dosage ranged from 16 Gy to 54 Gy. Eight patients were treated for palliation, three patients had post-operative irradiation and two patients were treated for recurrence after surgery. Palliation was achieved in six of the eight patients (75%). The results of our series of tests together with other reports suggest radiotherapy can contribute to palliation and post-operative irradiation as an adjunctive treatment.

Adenocarcinoma↗

Early esophageal carcinoma accompanied by esophageal varices: a case report.

This is a case report of early esophageal carcinoma accompanied by esophageal varices. Our conclusion from the experience is that when an esophagogram is performed on a patient with esophageal varices an air-contrast study in addition to an ordinary barium study should be performed as a routine examination.

Esophageal Neoplasms↗

Neurofibroma of the esophagus.

The authors describe a 50-year-old patient who was found to have a neurofibroma arising at the middle esophagus. The diagnosis of neurofibroma is based on endoscopy and roentgenology; however, it is necessary to base the exact diagnosis on endoscopical biopsy.

Esophageal Neoplasms↗

Intracavitary irradiation of esophageal carcinoma invaded to cardia.

A case of esophageal carcinoma that had invaded to the cardia was treated with intracavitary irradiation. The residual tumor was present at the cardia after radiotherapy. This result demonstrates that intracavitary irradiation is not necessarily effective for cases with invasion to the cardia of the stomach. Operation is recommended for such cases to obtain local control.

Aged↗

Recurrent esophageal carcinoma treated with intracavitary irradiation.

Two cases of esophageal recurrent carcinoma after past external irradiation were treated with intracavitary irradiation, but local control was not achieved in these two cases. These examples demonstrate that intracavitary irradiation for secondary treatment of recurrent esophageal cancer is not effective. Intracavitary irradiation should be performed primarily following external irradiation as a booster therapy.

Aged↗

Radiation treatment of esophageal carcinoma using a high-dose-rate remote afterloader.

Between May 1980 and October 1982, 25 patients with esophageal carcinoma were treated with a high dose rate, remote-controlled afterloading unit as a booster therapy for the intracavitary irradiation following external irradiation. All patients were observed in a follow up program which continued for more than 1 year after the beginning of radiation treatment. As of August 1983, 7 patients were alive and had had no local recurrence. Eighteen patients had died, of whom 9 had local failure. Local control rates at 6 months and 1 year were 67.3% and 62.1% respectively, which were significantly better than those in the group treated with external irradiation alone (p less than 0.01). Side effects were seen in 12 patients, but no special treatment was necessary. As for complications, esophageal ulcers were found in 24 patients, who, except for 2 patients, were all cured by conventional treatment. Other complications were 5 cases of stricture, 4 of esophago-bronchial fistula, 1 of esophago-aortal fistula, 1 of pulmonary fibrosis, and 1 of radiation osteitis. No radiation myelitis occurred.

Aged↗

Radiotherapy of T1 and T2 glottic cancer: analysis of anterior commissure involvement.

From January 1984 to December 1993, 184 patients with previously untreated T1 and T2 (UICC 1987) laryngeal glottic cancer underwent radiotherapy at Hyogo Medical Center for Adults. The prognostic variables analyzed included sex, age, smoking index, T stage, tumor size, tumor type, gross anterior commissure involvement (gross ACI), histological differentiation, administered dose, TDF, overall treatment time, chemotherapy, initial response, and the dose required to achieve CR. Both univariate and multivariate analyses were performed. The T stage, tumor size, and gross ACI were significant variables in univariate analysis, while the tumor type and gross ACI were significant on multivariate analysis. The 5-year recurrence-free survival of patients with gross ACI was significantly worse than that of those without ACI (57.6% vs. 89.9%). Among gross ACI patients, the recurrence-free survival of those treated with 70-72 Gy was superior to that of those receiving 60-62 Gy, suggesting that at least 70 Gy was necessary to control such diseases.

Adult↗

Marked improvement of tardive dystonia after replacing haloperidol with risperidone in a schizophrenic patient.

We report on a schizophrenic patient whose tardive dystonia, delusions, and auditory hallucinations showed remarkable concurrent improvement after replacing haloperidol with risperidone. The present finding suggests that the 5-hydroxytryptamine-2 (5-HT2) antagonistic action of risperidone has brought about the improvement in tardive dystonia. The 5-HT2 antagonistic action of risperidone, in addition to its dopamine antagonistic action, may have also lessened psychotic symptoms in the current case.

Antipsychotic Agents↗