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Biomedical subjects

Y Hishikawa

Publications and source records attributed to Y Hishikawa.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

Osteosarcoma following radiotherapy: a case report.

The case of a patient with postirradiation osteosarcoma is presented. The 20-year-old female was diagnosed as having osteosarcoma by histological examination of an open biopsy specimen. She underwent surgery for pure dysgerminoma and received adjuvant postoperative radiotherapy, 40 Gy to the pelvis and 30 Gy to the para-aortic region, 11 years ago. This case satisfied the criteria for radiation-induced osteosarcoma proposed by Cahan et al. Radiation-induced osteosarcoma is rare, but the possibility of that must be borne in mind.

Adult↗
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High-dose-rate intraluminal brachytherapy for postoperative residual tumor of gallbladder carcinoma: a case report.

The case of a patient with gallbladder carcinoma who had a postoperative residual tumor treated with high-dose-rate intraluminal brachytherapy (HDRIBT) and external radiotherapy (ERT) is presented. HDRIBT (20 Gy/2 fr) was performed at one point 10 mm from the 60Co source on 27 and 34 days after simple cholecystectomy. ERT (30 Gy/15 fr) was also given two weeks after HDRIBT. Following radiotherapy, she has been alive and well without signs of recurrence for one year and ten months as of this writing. HDRIBT combined with ERT is recommended for the treatment of post-operative residual tumors of advanced gallbladder carcinomas.

Adenocarcinoma↗
PubMedDate not supplied

Aneurysmal bone cyst treated by high-energy, low-dose radiation therapy: a case report.

Aneurysmal bone cysts (ABC) are frequently treated surgically, but recurrence is not uncommon and surgery is hazardous when the lesion is large and adjacent to the growth plate. High-energy, low-dose radiation to an 8-year-old girl with ABC of the distal tibia was found to be successful, with no recurrence during the five-year follow up. No complications have ensued, and excellent function has been sustained. Further evaluation of this radiation treatment is important for similar situations in which surgical excision of ABC may involve high risk.

Bone Cysts↗
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Primary rectal cancer treated with high-dose-rate intraluminal brachytherapy following external radiotherapy.

An 80-year-old man with rectal cancer who had diabetes and angina was treated with high-dose-rate intraluminal brachytherapy (30 Gy) following external radiotherapy (30 Gy). After this treatment, anal pain and bleeding improved greatly, and he was able to evacuate the bowels. However, the endoscopic biopsy taken five months after treatment revealed active cancer cells.

Adenocarcinoma↗
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Total lymphoid irradiation and total body irradiation for allogeneic bone marrow transplantation in aplastic anemia.

Between April 1980 and June 1989, 15 patients with severe aplastic anemia (SAA) were treated at Hyogo College of Medicine with bone marrow transplantation (BMT) after preparation consisting of cyclophosphamide (CY) and total lymphoid irradiation (TLI) or total body irradiation (TBI) for the purpose of reducing the incidence of graft rejection. All patients had initial evidence of engraftment after the first transplantation except for one patient who died of heart failure due to CY on the third day after transplantation and could not be evaluated for engraftment. Rejection later occurred in four of these 14 patients, who then underwent successful regrafting. One of these patients, who was conditioned with CY alone at the first grafting, underwent successful regrafting after a conditioning regimen of CY and TBI. In the other three patients, irradiation was performed twice as the conditioning regimen. Thus, 14 of 15 patients underwent successful BMT and are alive with restored hematopoietic function. From the above results, the combination of TLI or TBI and CY was considered to be very useful as a conditioning regimen for BMT in patients with SAA.

Adolescent↗
PubMedDate not supplied

Radiation therapy of the para-aortic lymph nodes in carcinoma of the uterine cervix: the concurrent use of cimetidine to reduce acute and subacute side effects from radiation.

A prospective study of the effects of radiation therapy (RT) on para-aortic lymph nodes in uterine cervical cancer was conducted. As part of the study, cimetidine (800 mg daily) was administered during RT to relieve and prevent adverse reactions of the gastrointestinal tract caused by RT. In half of the patients, cimetidine (400 mg daily) was continued after RT was finished. The RT field was 7 to 8 cm wide and covered the area from the 4th lumbar to 11th thoracic vertebrae. The total dose administered was 45 Gy in 25 fractions over a five-week period. From September 1986 through October 1987, 89 patients were entered in this study. During RT, only slight gastrointestinal symptoms, such as nausea, vomiting, appetite loss, fatigue, and epigastralgia, were observed. These symptoms increased when cimetidine was withdrawn, but not in the patients who continued to receive cimetidine. It is concluded that cimetidine during and after RT can reduce the acute and subacute side effects of RT.

Acute Disease↗
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Radiation treatment of superficial spreading carcinoma of the esophagus.

Superficial spreading carcinoma of the esophagus is a relatively rare disease. A 78-year-old man with this lesion was treated with high-dose-rate intracavitary irradiation (6 Gy) following external irradiation (48 Gy). The irradiated length was very long: 21 cm for intracavitary irradiation, which covered almost the entire thoracic esophagus, and 24 cm for external irradiation, which covered the entire thoracic esophagus. After treatment, he was well and could eat solid foods until his death, without tumor, two years and five months after radiotherapy. Intracavitary irradiation with a long irradiation length following external irradiation with a long irradiation length is recommended for the treatment of superficial spreading carcinoma of the esophagus.

Aged↗
PubMedDate not supplied

Esophageal pseudodiverticulum following high-dose-rate intracavitary irradiation for esophageal cancer.

Ninety-two patients with esophageal carcinoma were treated with combination therapy of external irradiation and high-dose-rate intracavitary irradiation. Four of the 92 patients developed esophageal pseudodiverticulum after radiotherapy. Histologically, all four patients showed squamous cell carcinoma before radiotherapy and were locally controlled by the combination therapy. In three of the four cases, pseudodiverticulum was found over one year after radiotherapy. In two of these three cases, pseudodiverticulum correlated with balloon dilatation performed for benign stricture. The pseudodiverticulum of the other case was found at the end of radiotherapy and was thought to be a traction diverticulum. None of the four patients developed a fistula. As of this writing, one of them has been alive and well for 50 months since the initiation of radio-therapy. Two of the other three died due to metastasis 18 months and 27 months later. The last one died due to intercurrent disease 39 months later.

Aged↗
PubMedDate not supplied

Esophageal fistula: demonstration by CT.

While barium esophagography is useful in revealing fistulas between the esophagus and trachea or bronchus, it is not adequate to show those between esophagus and lung or mediastinum. In this study, a patient with esophago-pulmonary and esophago-mediastinal fistulas was evaluated by CT, which proved to be more effective in showing fistulas between the esophagus and lung or mediastinum.

Aged↗
PubMedDate not supplied

Sonographic positioning of endouterine applicator.

Real-time ultrasonographic determinations of the position of an endouterine applicator (Tandem) were performed in patients with carcinoma of the uterine cervix at the time of intracavitary irradiation. Findings of ultrasonography (US) showed clearly the relation between the applicator for intracavitary irradiation and the uterine fundus. US is a valuable adjunct, which improves the accuracy of Tandem positioning.

Brachytherapy↗
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A multiple regression analysis for predicting local control of esophageal carcinoma treated by intracavitary irradiation.

A multiple regression analysis for predicting local control of esophageal carcinoma treated by intracavitary irradiation is reported. In phase I, the value of predicting local control (VPLC) was determined by five parameters: VPLC = 1.38950 - 0.01571 X (age) + 0.04517 X (tumor length) + 0.62167 X (stenosis) + 0.94811 X (deep ulcer) - 0.02969 X (Total dose of intracavitary irradiation). From correlations between VPLC and the local control observed in 19 phase I patients, it was determined that a VPLC value of 0.5 or more predicted local failure and a VPLC of less than 0.5 signified successful local control. In phase II, prediction of local failure or local control was made for another 24 patients by calculating VPLC, and 22 of the 24 cases (91.7%) were correctly predicted. These results indicate that VPLC is a useful index for predicting of local control after intracavitary irradiation in cases with esophageal carcinoma.

Brachytherapy↗
PubMedDate not supplied

Radiotherapy of pancreatic fistula.

A case report of pancreatic cutaneous fistula treated with radiotherapy is presented. Our conclusion from the experience is that when pancreatic fistula does not close spontaneously and conservative treatment is not effective, radiotherapy should be considered as another therapeutic modality.

Chronic Disease↗
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Sacrococcygeal chordoma: CT appearance after radiotherapy.

This report presents the CT findings after radiotherapy in a case of sacrococcygeal chordoma. Observation over a long period following radiotherapy was necessary for this sacrococcygeal chordoma patient because of the slow regression of the tumor. CT was a highly effective tool in observing changes in the tumor.

Chordoma↗
PubMedDate not supplied

Radiation treatment of varicoid carcinoma: a case report.

The authors describe a 70-year-old male who was found to have varicoid carcinoma of the esophagus. He was treated with combined external irradiation and intracavitary irradiation; however, the cancer was not locally controlled.

Aged↗
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Histological findings of esophageal injury induced by intracavitary irradiation.

The histological findings of esophageal injury induced by intracavitary irradiation are reported. In the portion irradiated intracavitarily, denudation and regeneration were found in the epithelium, degenerative changes of small vessels and fibrotic changes were found in the submucosa, and fibrotic changes were also found in the muscle layers. Our data suggest that these characteristic changes correlate with the additional dosage given by intracavitary irradiation following external irradiation.

Aged↗