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Biomedical subjects

Y Hamashima

Publications and source records attributed to Y Hamashima.

At least 145 records · Page 8Linked to original sources
PubMed1982

Lymphocytotoxic autoantibodies in pemphigus and systemic lupus erythematosus.

Lymphocytotoxic autoantibody (LCTA) was studied in 9 patients with active pemphigus and 19 patients with active systemic lupus erythematosus (SLE). All patients with SLE showed high titres of LCTA but only one patient with pemphigus had LCTA. In this paper we discuss the immunological significance of LCTA and the difference in the incidence of LCTA between pemphigus and SLE. In addition we present the clinical features of the case with LCTA-positive pemphigus and suggests that the presence of LCTA is due to the common viral infection.

Antilymphocyte Serum↗
PubMed1981

Idiopathic acute myocarditis with complete atrioventricular block in a baby. Clinicopathological study of the atrioventricular conduction system.

A 17-month-old Japanese girl with an idiopathic acute myocarditis had symptoms of vomiting, slight fever, and liver enlargement, but no edema. Clinical diagnosis of acute myocarditis was not made until she had Stokes-Adams syndrome and electrocardiogram revealed complete atrioventricular block on the day of death. At autopsy, idiopathic acute myocarditis was detected diffusely in the right and left ventricles. Vomiting and liver enlargement were due to congestive heart failure. Serial sections of the atrioventricular conduction system revealed diffuse and severe acute inflammatory changes in the right bundle and the left bundle branches, especially in the terminal portions. Acute inflammation was focally noted in the atrioventricular node and the His bundle. The complete atrioventricular block probably followed the severe acute inflammation of the bundle branches. Our case suggest that idiopathic acute myocarditis may be underdiagnosed in babies, as there is no way to determine whether there is dyspnea and palpitation on exertion, and idiopathic fibrosis of conduction system with or without conduction disturbances in children and adults may be sequelae of healed myocarditis in babies.

Acute Disease↗
PubMed1981

Association between circulating immune complexes and renal disease in New Zealand mice.

Using female NZB x NZW (B/W) F1 x NZW backcross mice, analyses were made to determine the correlations among C1q- binding and conglutinin (Kg) binding immune complexes in the circulation and the proteinuria of the B/W F1 mice. There was a significant association between the development of proteinuria and the high serum level of Kg-binding immune complexes, while no significant association was seen between the proteinuria and the C1q-binding immune complexes in the backcrosses. There was a lack of correlation between these C1q-binding and Kg-binding immune complexes. These results suggest that the major immune complexes detected by these two methods differ in nature and emphasize that the demonstration of antigen-non-specific immune complexes in the circulation do not necessarily mean that these immune complexes are responsible for the pathogenesis of the particular disease being studied.

Animals↗
PubMed1980

General pathology of Kawasaki disease. On the morphological alterations corresponding to the clinical manifestations.

Systemic pathological alterations were studied in thirty-seven autopsied patients with Kawasaki disease. Systemic vasculitis was the most characteristic pathological finding and was present in all the patients. In addition to the vasculitis, there was a high incidence of inflammatory lesions in various organs and tissues: in the heart, endocarditis, myocarditis, and pericarditis; in the digestive system, stomatitis, sialoduct-adenitis, catarrhal enteritis, hepatitis, cholangitis, pancreatitis, and pancreas ductitis; in the respiratory system, bronchitis and segmental interstitial pneumonia; in the urinary system, focal interstitial nephritis, cystitis, and prostatitis; in the nervous system, aseptic leptomeningitis, choriomeningitis, gangliontis, and neuritis; in the hematopoietic system, lymphadenitis, splenitis, and thymitis. Dermatitis, panniculitis or myositis were also observed in some patients. Therefore, Kawasaki disease is a systemic inflammatory disease which mainly affects the cardiovascular system. These systemic inflammatory lesions are considered to correspond to the variegated clinical manifestaitions. The relationship between Kawasaki disease and infantile polyarteritis nodosa (IPN) were discussed, based on the clinicopathological characteristics.

Child↗
PubMed1979

Myocardial fascicle and fiber disarray in 25 mu-thick sections.

We compared the histologic picture of myocardial fiber disarray in thin (4 mu) and thick (25 mu) sections of tissues obtained at autopsy from 18 adults and eight infants with clinically normal hearts, from 10 hearts with concentric hypertrophy (hypertensive patients), nine with myocardial infarction and four with hypertrophic cardiomyopathy (HCM). In the thick sections, so-called bizarre myocardial fiber disarray in thin sections was seen as a bizarre fascicle disarray. Therefore, the usual fiber disarray reported in cases of HCM is actually a fascicle disarray with a three-dimensional complex network. There was no marked difference in distribution and frequency of fascicle disarray among normal adult and infant hearts, and diseased hearts with hypertension and myocardial infarction. In the four hearts with HCM, diffuse bizarre fascicle disarray in the thick section was detected in the septum and anterior and posterior walls of the left ventricles in all cases, and in the lateral walls in one case. In the portions without the diffuse fascicle disarray, the distribution of disarray was the same as that in hearts with no HCM. Such fascicle disarray, including that of HCM, is probably congenital.

Adult↗
PubMed1979

Pathology of Kawasaki disease: I. Pathology and morphogenesis of the vascular changes.

Histopathological investigation of the vascular changes in Kawasaki disease was carried out on thirty-seven autopsied Japanese patients. Arterial lesions could be classified into following five stages from the view point of morphogenesis of arteritis; 1) endothelial degeneration and increased vascular permeability, 2) edema and degeneration of the media, 3) necrotizing panarteritis, 4) granulation formation, and 5) scarformation. Aneurysm with thrombus was observed mainly in the coronary artery in most patients. It is considered that the initial changes begins in the endothelial cells with increased vascular permeability. Platelet aggregation in the damaged endothelial cells seems to play an important role in the further development of the arteritic changes. Vascular lesions were observed not only in the arterial system but also in the venous system, therefore Kawasaki disease is a systemic vasculitis rather than a systemic arteritis.

Aneurysm↗
PubMed1979

Pathology of Kawasaki disease: II. Distribution and incidence of the vascular lesions.

Histopathology, distribution and incidence of vascular changes were studied in tissues obtained at autopsy on thirty-seven children. Elastic and musculoelastic arteries showed a high incidence of arteritic changes, however the degree of the lesions was in general mild to moderate with the exception of the iliac artery, which revealed severe changes and a necrotizing panarteritis which was often accompanied with an aneurysm formation. A high incidence of arteritic changes, of which main histological feature was necrotizing panarteritis, was seen in extravisceral middle sized arteries. The coronary artery in particular was involved in each case and most had an accompanying aneurysm, some of which had ruptured. Intravisceral small sized arteries showed a relatively low incidence of arteritic changes and the degree of inflamation was in general mild. Phlebitis was present in over half the number of patients. The degree of lesions was mild in the small veins and mild to moderate in the large veins. Vascular lesions in Kawasaki disease should be termed systemic vasculitis rather than a systemic arteritis. There was a correlation between the caliber of involved vessels and the degree of vascular lesions. According to the histopathology, distribution and incidence of angitis, Kawasaki disease does resemble infantile periarteritis nodosa with the exception of the different manner of the coronary and iliac involvement.

Aorta↗
PubMed1979

Suppression of cellular immune response in chemically sympathectomized mice.

Delayed-type hypersensitivity to methylated bovine serum albumin (MBSA), as induced by 6-hydroxydopamine (6-OHDA) was studied in chemically sympathectomized mice. Footpad reaction at 48 h after challenge injection of MBSA was suppressed with doses ranging from 10--300 mg/kg. 6-OHDA was neither cytotoxic to peritoneal macrophages nor was the function of immunoglobulin mediated phagocytosis suppressed. Thus, the suppression of delayed-type hypersensitivity may be attributed to interference with T-cell function.

Animals↗