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Biomedical subjects

Y Hamashima

Publications and source records attributed to Y Hamashima.

At least 127 records · Page 7Linked to original sources
PubMed1983

Osteofibrous dysplasia (ossifying fibroma of long bones). A study of 12 cases.

Osteofibrous dysplasia (ossifying fibroma of long bones) is one of the fibro-osseous lesions that affects the tibia and fibula in the first decade of life. A study of 12 patients with this lesion showed the high rate of recurrence after surgical intervention. Most commonly, the lesions are eccentrically located in the diaphysis of the tibia. Pseudarthrosis may develop in cases where the lesion is situated in the distal portion. Roentgenologic and histopathologic features are basically similar to those of monostotic fibrous dysplasia of long bones. However, bony or osteoid trabeculae covered by osteoblasts enable distinction between osteofibrous dysplasia and monostotic fibrous dysplasia, as determined histologically. The current evidence indicates that surgery should not be attempted in patients under 10 years of age.

Bone Neoplasms↗
PubMed1983

Evaluation of circulating immune complexes and antinuclear antibodies in Japanese patients with leprosy.

In 79 patients with leprosy a significant increase of anti-extractable nuclear antigen (ENA) antibodies and circulating immune complexes (CIC) was found. No correlation between CIC and anti-ENA antibodies was demonstrable. Since such a correlation is known from antinuclear antibodies and CIC in patients with systemic lupus erythematosus, it appears likely that anti-ENA antibodies do not play a causative role in CIC-mediated pathogenesis of leprosy.

Adult↗
PubMed1983

A comparative immunologic study of IgA nephropathy.

A conglutinin binding assay has been used to detect circulating immune complexes (CIC) containing IgA, IgG, or IgM in sera from patients with IgA nephropathy. IgA class CIC were detected in 40.7% of patient. IgG class CIC were detected only in patients with glomercular IgG deposits. IgM class CIC were detected more often in patients with glomerular IgM deposits than in patients without glomerular IgM deposits. These results demonstrate an association between the immunoglobulin in CIC and those in glomerular deposits. CIC were not detected in sera from most patients with IgA nephropathy by a Clq binding assay, however, since this assay does not detect IgA class CIC. Immunoelectronmicroscopic studies of IgA nephropathy have shown that C3 deposits are localized to the same areas as IgA deposits. In conclusion, we suggest that mesangial IgA deposits are composed of immune complexes and may be derived from CIC.

Antigen-Antibody Complex↗
PubMed1983

An overlapping syndrome of IgA nephropathy and membranous nephropathy?

This is the first report of primary glomerular disease with both mesangial IgA and subepithelial IgG deposits in the glomeruli at the same time. This nephropathy, discovered in 3 patients, is either a new disease entity or an overlapping of IgA nephropathy and membranous nephropathy. Follow-up studies may clarify the pathogenesis of IgA nephropathy and/or membranous nephropathy. In 1 patient the clinical findings resembled those of IgA nephropathy, and in the other 2 they were those of membranous nephropathy. Light microscopy showed generalized diffuse increases in mesangial cells and matrix, and there was slight capillary wall thickening. In the glomeruli, immunofluorescence microscopy demonstrated both granular deposits of IgA in the mesangium and granular deposits of IgG along the capillary loops. On electron microscopy, electron-dense deposits were identified not only in the mesangium but also on the epithelial side of the glomerular basement membrane. These findings were confirmed by the immunoperoxidase technique in electron-microscopic studies of these antibody classes. These glomeruli contained both the dense reaction products of IgA deposits in the paramesangium and mesangial matrix and the dense reaction products of IgG deposits on the epithelial side of the basement membrane.

Adult↗
PubMed1983

Myocardial fiber diameter and regional distribution in the ventricular wall of normal adult hearts, hypertensive hearts and hearts with hypertrophic cardiomyopathy.

Myocardial fiber diameters were measured to determine their distribution throughout the ventricular wall in normal adult hearts, hypertensive hearts and hearts with hypertrophic cardiomyopathy (HCM). In normal adult hearts and hypertensive hearts, the diameter decreased from the inner to the outer third of the left ventricular free wall and from the left ventricular side to the right ventricular side of the septum. In HCM, these regional differences were preserved in the left ventricular free wall, but not in the septum. The diameter was greatest in the middle third of the septum, where myocardial fiber disarray was widely distributed. The diameters of the fibers in the right ventricular side of the septum were significantly larger than those of the fibers in the left ventricular side of the septum in HCM. This finding, in contrast to that in normal adult hearts or hypertensive hearts, was considered to be related to the inward convex curvature of the left ventricular chamber. Although there was no significant difference in the diameter of myocardial fibers in the left ventricular free wall between hypertensive hearts and hearts with HCM, the diameters of those in the right ventricular free wall, in the right ventricular side of the septum and in the middle third of the septum were significantly larger in HCM than in hypertensive hearts. We conclude that there is a transmural variation of myocardial fiber diameter in the left ventricular free wall and the ventricular septum, and such transmural variation in HCM is clearly different from that in hypertensive hearts.

Adult↗
PubMed1982

Circulating immune complexes of IgG, IgA, and IgM classes in various glomerular diseases.

In order to examine the correlation between immunoglobulin (Ig) classes of immunoglobulins in circulating immune complexes (CIC) and immunoglobulins in glomerular deposits, we have measured CIC of IgG, IgA and IgM classes in various glomerular diseases. Serum CIC were measured using a modified conglutinin binding assay (K assay) using 125I-labeled anti-gamma, anti-alpha and anti-mu antisera. IgA class CIC were detected in more patients with IgA nephropathy than patients with non-IgA nephropathy. There was an association between the presence of IgG deposits in kidneys and the presence of IgG in CIC. Patients with IgA deposits in their kidneys also had IgA class CIC. There was also an association between the presence of IgM deposits in kidneys and the presence of IgM in CIC. These results suggest that the Ig class in CIC and the Ig class in glomerular deposits were correlated, and that in IgA nephropathy the mesangial IgA deposits may be derived from IgA class CIC.

Antigen-Antibody Complex↗
PubMed1982

Diagnostic value of disarray in endomyocardial biopsy specimens in hypertrophic cardiomyopathy: a critical report based on distribution of disarray in the subendocardial region of autopsied hearts.

Myocardial fiber disarray in endomyocardial biopsies is considered to be a histologic feature of hypertrophic cardiomyopathy (HCM). To determine whether this disarray is specific for HCM, we examined the distribution of disarray in the subendocardial region in 11 autopsied hearts from patients with HCM and 41 autopsied control hearts. The percent area of disarray in the subendocardial region of the right ventricular side of the septum with maximum septal hypertrophy was 9 +/- 3% in HCM and 4 +/- 2% in the controls (p less than 0.001). The frequency of occurrence of disarray in this area was 38 +/- 10% in HCM and 20 +/- 7% in the controls (p less than 0.001). Disarray covering over 76% of a visual field, although extremely rare, was specific for HCM. In the right ventricular side of the septum in the lower half and in the left ventricular free wall, there was no significant difference between HCM and controls in regard to the percent area of disarray and its frequency of occurrence. In conclusion, although disarray in right ventricular endomyocardial biopsies is considered to be more frequent in HCM than in the controls, too much emphasis should not be placed on disarray in endomyocardial biopsy specimens as a diagnostic criterion for HCM.

Adult↗