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Biomedical subjects

Y Fujioka

Publications and source records attributed to Y Fujioka.

At least 181 records · Page 10Linked to original sources
PubMed1985

[Clinical trial of MCNU for malignant brain tumors].

A total of 71 cases with primary brain tumors (44 cases) and metastatic brain tumors (30 cases) were entered into our clinical studies with MCNU and radiation therapy or MCNU alone. With regard to tumor reduction on CT scan, the response rates obtained for MCNU and radiation were 21.7% for malignant gliomas and 50.0% for metastatic brain tumors. With regard to improvement of neurological signs, the response rates obtained for MCNU and radiation were 62.9% for malignant gliomas and 71.4% for metastatic brain tumors. The response rates for MCNU were 5.8% for malignant gliomas and 46.1% for metastatic brain tumors. In the improvement of performance status, the response rates for MCNU and radiation were 51.8% for malignant gliomas and 64.2% for metastatic brain tumors. The response rates for MCNU were 46.1% for malignant gliomas and 30.7% for metastatic brain tumors. A minimal degree of hematological toxicity occurred but this gradually disappeared. These results suggested that MCNU has relatively effective antitumor activity against metastatic brain tumors and an enhanced effect with radiation against malignant gliomas.

Antineoplastic Agents↗
PubMed1985

Induction of gliomas in Mongolian gerbils (Meriones unguiculatus) following neonatal administration of N-ethyl-N-nitrosourea.

Mongolian gerbils (Meriones unguiculatus) were given an sc injection (40 mg/kg body wt) of N-ethyl-N-nitrosourea [(ENU) CAS: 759-73-9] on postnatal day 1 (group I) or day 29 (group II). Untreated gerbils served as controls (group III). Of 32 gerbils in group I, 10 (31%) developed a total of 14 gliomas after an observation period of 12 months, whereas no gliomas were observed in groups II and III. Seven gliomas were located in the spinal cord, 6 were in the cerebrum, and 1 was in the cerebellum. Histologically, all were oligodendrogliomas. In group II, 1 meningeal tumor (4%) was observed among 27 gerbils. ENU also induced cutaneous melanomas (22% in group I, 15% in group II, and 0% in group III), kidney hemangiomas (6% in group I, 26% in group II, and 0% in group III), and ameloblastomas of the lower jaw (6% in group I and 0% in groups II and III).

Animals↗
PubMed1985

Pigmented variant of calcifying odontogenic cyst. Report of an additional case and review of the literature.

A case of the pigmented variant of calcifying odontogenic cyst occurring in a 21-year-old Japanese male is reported, and a review of previously reported cases of the lesion is included. In addition to the characteristic histopathologic features of calcifying odontogenic cyst, dendritic cells containing melanin pigment were widely distributed in the epithelial layer and melanin pigment was also found in the epithelial cells including ghost cells in the present case. Although no conclusion could be drawn from the present examination as to the origin of melanin pigment in the calcifying odontogenic cyst, it is thought that the role of racial pigmentation is one of the important factors in occurrence of pigmented odontogenic lesions.

Adult↗
PubMed1984

[Meningioma and acoustic neurinoma occurring in two siblings of two different families].

The authors reported familial brain tumors in which meningioma and acoustic neurinoma occurred in two siblings of each two families with no evidence of the neurocutaneous syndromes, nor the familial cancer syndromes. Case A-1 is a 49-year-old female admitted to the hospital because of bilateral visual disturbance in July of 1976. A suprasellar mass was observed by CT scan. Right frontal craniotomy and removal of the tumor were done in July of 1976. Histological diagnosis was meningothelimatous meningioma. Case A-2 is a 47-year-old female, a younger sister of case A-1. Tinnitus, hearing disturbance, hemifacial sensory involvement of right side and impaired gait occurred at the end of 1981. Tomography revealed the dilatation of the right internal auditory canal. A multicystic mass was observed at the right cerebellopontine angle by CT scan. An operation was performed in May of 1982, and the tumor was diagnosed as Antoni A type neurinoma. Case B-1 is 23-year-old male who was admitted to the hospital in April of 1975, following the sudden onset of general convulsion. Left carotid angiogram showed the elevation of middle cerebral arteries and a tumor stain at the left temporal region. An operation was performed to remove the left sylvian tumor in April of 1975, and the tumor was diagnosed as transitional meningioma. Case B-2 is a 32-year-old female, an elder sister of case B-1. Bilateral tinnitus and hearing disturbance occurred in 1973. She complained left hemifacial sensory involvement and impaired gait in July of 1979. CT scan showed mass lesions with markedly contrast enhancement effect at the bilateral cerebellopontine angles. An operation was performed to remove the left tumor in November of 1979 and the right tumor in July of 1980. Histologically the both tumors were diagnosed as Schwannoma. The authors have collected reports of 117 families in which intracranial tumors occurred without evidence of the neurocutaneous syndromes and the familial cancer syndromes. Six out of 117 families showed histologically different kind of tumors, however the combination of meningioma and neurinoma could not be found. Consequently our cases of meningioma and neurinoma occurred in two siblings of two different families must be the first report.

Adult↗
PubMed1984

[Evaluation of serum tissue polypeptide antigen (TPA) in patients with urogenital cancer].

The level of serum TPA was determined by radio-immunoassay in 19 healthy subjects and 90 patients with urogenital cancer. The normal level of serum TPA was 86 +/- 24 U/l, and the level of more than 134 U/l was determined positive. The positive rate of TPA was 38.9% in 90 patients, while that of CEA was 25.6%. In 19 patients with bladder tumor and 7 with testicular tumor, the positive rates of TPA were 52.6% and 71.4%, respectively, and the level of serum TPA was high in these positive patients. Considering the low positive rate of CEA, TPA may be a more useful marker than CEA in patients with bladder tumor and testicular tumor. Serial determinations of serum TPA and CEA showed the considerable variation of serum TPA compared with serum CEA and a temporary elevation of serum TPA following radical nephrectomy and retroperitoneal lymphadenectomy. However, the level of serum TPA fell significantly after the successful treatment in 8 patients (2 with renal cell cancer, 3 with bladder tumor, 1 with prostate cancer, 2 with testicular tumor) and rose sharply with recurrent or metastatic disease in 4 patients (2 with bladder tumor, 2 with testicular tumor). Although there was no correlation between the levels of serum TPA and serum PAP, the level of serum TPA tended to change in parallel with the level of serum AFP or HCG in 3 patients with testicular tumor.

Adenocarcinoma↗
PubMed1983

Immediate reconstruction using a scalp-forehead flap for the entire upper lip defect with the application of lyophilized porcine skin to surgical wounds. A case report of a malignant melanoma in the upper lip and oral mucosa.

A rare extensive malignant melanoma involving the upper lip and maxillary alveolar mucosa was removed by en bloc resection after chemotherapy and radiotherapy. Simultaneous immediate reconstruction of the entire upper lip defect was carried out with a bitemporal pedicle flap which included the scalp and forehead after applying lyophilized porcine skin to the wound where the alveolar bone had been resected, and the bilateral scalp-forehead and thigh donor sites. A partial denture was inserted six months postoperatively. Now, one and a half years after operation, the patient is quite satisfied with his cosmetic appearance and masticatory recovery.

Adult↗
PubMed1983

[In vitro antitumor activity of 7-N-(p-hydroxyphenyl)-mitomycin C (KW-2083) against cultured bronchogenic carcinoma cells (PC-7)].

The in vitro antitumor activity of 7-N-(p-hydroxyphenyl)-mitomycin C (KW-2083) against cultured bronchogenic carcinoma cells (PC-7) was compared with that of mitomycin C, using a 3H-thymidine uptake assay. The uptake of 3H-thymidine into PC-7 cells was well correlated with the cell concentration under 1 X 10(5)/ml. It was more strongly inhibited after incubation of the PC-7 cells with KW-2083 than with mitomycin C at the concentration of 0.5, 2.5 and 10 micrograms/ml for 20 and 60 min. The placebo of KW-2083 containing HCO-60 and propyleneglycol showed no effect on the uptake of 3H-thymidine by PC-7 cells.

Carcinoma, Bronchogenic↗
PubMed1983

[Augmentation of the cytostatic activity of granulocytes by biological response modifiers (BRM)].

The effects of various biological response modifiers (BRM) such as Nocardia rubra cell wall skeleton (N-CWS), OK-432, muramyl dipeptide (MDP), Staphylococcal protein A, interferon, lymphokine on the cytostatic activity of granulocytes against cultured tumor cells were examined. The cytostatic activity of untreated granulocytes from 10 normal healthy volunteers ranged from 14% to 30%. Lymphokine obtained from the supernatant of lymphocytes cultured with Con A-Sepharose directly suppressed the DNA synthesis of K 562 cells in high concentration, however, other BRM showed no direct cytostatic activity. The cytostatic activity of granulocytes was augmented by low concentrations (2.5 micrograms/ml) of N-CWS, OK-432 and protein A as well as by high concentration (25 micrograms/ml) of MDP. However, the cytostatic activity was not influenced by alpha-interferon. The meanings and mechanisms of the elevation in cytostatic activity of granulocytes by BRM were discussed with regards to the clinical immunotherapy.

Acetylmuramyl-Alanyl-Isoglutamine↗
PubMed1981

Intraepithelial atypical lymphocytes in oral lesions of Behçet's syndrome.

Atypical lymphocytes with deep nuclear indentations, identical to those observed in Sézary syndrome and mycosis fungoides, were demonstrated by electron microscopy in the prickle-cell layer of the oral epithelium of patients with Behçet's syndrome. Many of these cells were present in association with macrophages.

Behcet Syndrome↗
PubMed1979

Glycolipids in human lung carcinoma of histologically different types.

Glycolipids were isolated from primary human lung carcinoma tissue of various histologic types: adenocarcinoma, squamous cell carcinoma, and undifferentiated small cell carcinoma. Each type of carcinoma had a characteristic glycolipid pattern. The major glycolipids isolated were ceramide monohexosides, ceramide dihexosides, ceramide trihexosides, globoside, and hematoside. Squamous cell carcinoma and undifferentiated small cell carcinoma showed marked increases of ceramide monohexosides and dihexosides. Adenocarcinoma had a much higher level of the sulfatide (ceramide 3-sulfate-galactoside) as compared to squamous cell carcinoma, undifferentiated small cell carcinoma, or normal lung tissue. Embryonic tissue had more significant levels of sulfatide than did the other carcinomas. Adenocarcinoma had significantly lower levels of glycolipids due mainly to a decrease in the amount of ceramide monohexosides and dihexosides and hematoside.

Adenocarcinoma↗