Subunits of human chorionic gonadotropin and their radioimmunoassays.
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Animals↗
Biomedical subjects
Y Endoh
Publications and source records attributed to Y Endoh.
Poisoning in children in Japan.
The Japan Poison Information Centre (JPIC) received 31,510 inquiries about poisoning in children under 6 years old being exposed to poison in the fiscal year 1995. The most frequently implicated products were tobacco (20%) and the peak age for ingestion of household products was 1 year and younger (83.3%). Especially, the inquiries related to children less than 1 year old were 35.7% of the cases. In contrast, the American Association of Poison Control Centers (AAPCC) data showed that the most common poisonings were due to pharmaceutical products and the inquiries related to children less than 1 year old were only 12.1%. The objective of this report was to find out the poison exposure in children in Japan and to compare the data with that of AAPCC.
Adolescent↗
Causes and time course of acute hemolysis after burn injury in the rat.
Thermal injury can cause acute red blood cell damage and destruction, but the mechanisms of these effects are not well described. To investigate the red blood cell abnormalities that occur after burn injury we studied the time course of red blood cell changes that are seen early after burn injury. Male Sprague-Dawley rats were divided into control, sham-burn, and burn (30% total body surface area full-thickness) groups. Plasma-free hemoglobin, erythrocyte osmotic fragility, and red blood cell membrane deformability were measured in the first 8 hours after burn injury. Plasma-free hemoglobin was significantly increased 1 hour after injury. It fell promptly but remained significantly higher than the control value at 4 and 8 hours after burn injury. Osmotic fragility was also significantly increased when compared with control values, whereas membrane deformability was less than control values for the duration of the experiment. This study identifies an early hemolytic effect of burn injury and documents red blood cell changes in osmotic fragility and membrane deformability that may contribute to accelerated red blood cell loss later in the course of burn management.
Animals↗
Improvements in rheologic properties of blood by fluid resuscitation after burn injury in rats.
Severe burn injury impairs tissue perfusion both by adversely altering the rheologic properties of blood and by decreasing circulating blood volume. Although resuscitation is known to improve perfusion by increasing whole blood volume, it is possible that it may also improve blood flow. To assess these latter effects of resuscitation after burn injury, we studied several determinants of blood flow. Burned animals were resuscitated with 20 ml of lactated Ringer's solution given intraperitoneally. This fluid resuscitation significantly improved the hemoconcentration that was produced by burn injury (p less than 0.05). Burn injury caused an increase in free plasma hemoglobin (p less than 0.05). Fluid resuscitation after injury reduced free plasma hemoglobin compared with that of the burned animals (p less than 0.05), although it still remained higher than free plasma hemoglobin in unburned controls (p less than 0.05). Increased whole blood viscosity and increased osmotic fragility, which were caused by burn injury, were also corrected by fluid resuscitation. Finally, the decrease in red blood cell membrane deformability that is associated with burn injury was improved by resuscitation, although it never completely returned to normal. These results demonstrate beneficial effects of fluid resuscitation on rheologic properties of blood after burn injury. Restoration of blood flow to tissue by resuscitation after burn injury may be due to improved blood rheology as well as to intravascular volume loading.
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