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Biomedical subjects

Y Badonnel

Publications and source records attributed to Y Badonnel.

25 records · Page 2Linked to original sources
PubMedDate not supplied

[Validity of immunochemical methods for bloody progesterone: a study performed in 1998].

The aim of this study was to compare, with manufacturer's agreement, twelve direct and non-isotopic commercial assays of progesterone. We have evaluated the analytical performances: low limit detection, imprecision, accuracy (recovery and dilution tests) and we have tested some patient samples. Results were compared to a reference method using isotope dilution Gas Chromatography and Mass Spectrometry combination (GC-MS). For each assay, analytical qualities and defaults are established. Large differences are found between progesterone concentration measured on the same sample with the different methods essentially for the low concentrations. Comparison with GC-MS raised questions about the accuracy of the different assays. This work will be aid laboratories to their choice and/or validation.

Acridines↗
PubMedDate not supplied

[The choice between theophylline and caffeine in the treatment of apnea in premature infants].

In a double blind study, two comparable groups (each n = 10) of premature infants less than 34 weeks of gestational age, with idiopathic apnea were given an IV treatment of either theophylline or caffeine. The loading doses were respectively 6 and 10 mg/kg and the maintenance doses were 2 and 1.25 mg/kg every 12 hours. In both groups, apneas greater than or equal to 15 s. with or without bradycardia were similarly reduced (p less than 0.01). Both drugs increased significantly the respiratory rate. Compared to caffeine, theophylline induced a significant acceleration of heart rates, an increase in urinary sodium excretion, more frequent gastrointestinal intolerance and behavioral changes. Plasma concentrations of theophylline were less stable than those of caffeine. These data suggest that a single daily dose of caffeine should be preferentially used in the treatment of idiopathic apneas of prematurity.

Caffeine↗
PubMedDate not supplied

[Pregnancy and perinatality: biological follow-up].

Blood and urinary tests which are necessary for pregnancy diagnosis and follow-up, for newborn and mother medical supervision, during the month following birthday, are today described in reglementary texts, laws, and recommendations such as advised medical references (RMO). These documents specify the nature of obligatory tests, the checking rhythm and the list of useless tests. hCG research remains necessary for pregnancy diagnosis, but hCG dosage is essential only in case of programmed medical assistance or pathological pregnancy (extrauterine pregnancy, hydatiform mole, choriocarcinoma). The obligatory follow-up of a pregnant woman includes determination of blood groups, research of infectious agents responsible for diseases (toxoplasmosis, rubeola, hepatitis B, syphilis), proteinuria and glycosuria research and blood count according to a given calendar. When the mother's condition is bad and reminiscent of a pathological pregnancy, when a genetic risk exists for the fetus or when fetal growth is abnormal as indicated by echographic control (intra-uterine growth retardation), laboratory tests are used to follow the maternal pathological course (arterial hypertension, diabetes mellitus, anemia, bacterial, viral or parasitic disease), to verify the existence of a genetic disease, to know about the fetal functional state (by amniocentesis or cordocentesis), to identify an erythrocyte fetomaternal incompatibility. Since last trimester pregnancy accidents are able to endanger mother's and fetus lives, the feto-maternal follow-up must be adjusted to pathological diagnosis types and requires a particular supervision of the delivery. Finally mother and child must undergo a post-natal follow-up during the four weeks after birthday (perinatality control).

Female↗
PubMedDate not supplied

[Laboratory follow-up in menopause].

Menopause is not an illness. Nevertheless, nowadays, it is medically approached. We know now with precision the consequences of the estrogen deficiency on about fifty woman's wellbeing, on her metabolism, her cardiovascular system, her bones. A substitutive hormonal therapy is more and more often proposed in order to correct the immediate functional disorders and to prevent the long term consequences (cardiovascular diseases and osteoporosis especially). What is the place of biology in the follow-up of a menopausal patient? Even if clinic observation is predominant for the diagnosis of menopause, plasmatic FSH and estradiol assays are of precious aid in particular cases (hysterectomised patients for example). Whether or not we consider a substitutive hormonotherapy, menopause installation is a good opportunity for detection of metabolic diseases, beginning often in this part of life or clinically suspected. Before beginning a substitutive treatment, biological assays contribute to define the patients's metabolic profile in order to adjust the choice between oral or percutaneous estrogenotherapy and to detect contra-indications. The biological markers of osteoporosis risk are objective arguments to incite indecisive women for beginning or for continuation of a treatment. Under hormonotherapy, plasmatic estradiol's assay should aid to confirm the correct adequation of substitutive doses, but in practice it is not much used: clinical examination is generally adequate to detect under or over dosage. In post-menopause, wether or not she receive a substitutive hormonal therapy, every women should have the benefit of a regular biological follow-up, in the same way as a mammography and cervical smears are recommended. Age being by oneself the main factor for metabolic risk, early detection and early correction of abnormalities will be the main part to ensure quality, for women and also for men, of the second half time of their life.

Aged↗