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Biomedical subjects

Y Baba

Publications and source records attributed to Y Baba.

At least 289 records · Page 16Linked to original sources
PubMed1985

[Fundamental and clinical studies of cefpimizole in obstetrics and gynecology].

Cefpimizole (AC-1370) concentrations in the pelvic dead space exudate were determined in patients under-going curative resection of carcinoma of the uterine cervix to study the transfer of the drug into the female genital organs, and the results were statistically analyzed, using the two-compartment model. When 1 g of AC-1370 was administered by intravenous drip infusion over 1 hour, the AC-1370 concentration in the serum from the antecubital vein reached a level of 129.09 micrograms/ml at 1 hour of intravenous drip infusion, and the AC-1370 concentration in the pelvic dead space exudate reached a peak of 30.32 micrograms/ml at 2.51 hours of intravenous drip infusion, and remained at not less than 12 micrograms/ml 8 hours after the beginning of the drip infusion, with the area under the curve (AUC) for the AC-1370 concentration in the pelvic dead space exudate being 213.66 micrograms X hr/ml. Seven patients with obstetrical and gynecological infections were treated with 1 g of AC-1370 by intravenous drip infusion over 1 hour, 2 approximately 3 times daily. Although the patients all had rather mild infections, the treatment was effective in all of them. The findings in this study proved a dose of 1 g of AC-1370 at a time to be sufficiently effective in mild cases, but in view of the transfer of the drug into tissues, it seemed necessary to administer 2 g of the drug at a time in severe cases.

Adult↗
PubMed1984

Circulating immune complexes and granulocytes chemotaxis in Kawasaki disease.

Serum immunoglobulin levels, complement titers, circulating immune complex levels, and chemotaxis of granulocytes were evaluated in 32 patients with Kawasaki disease with or without coronary aneurysm. The group of patients with coronary aneurysm showed relatively higher levels of IgG. Regardless of the presence of coronary aneurysm, the level of IgE in the acute phase was higher than that in the convalescent phase. The level of immune complexes was higher in the group of patients with coronary aneurysm (p less than 0.05). There was a low negative correlation between immune complexes and CH50. The chemotaxis of the patients with coronary aneurysm was significantly impaired (p less than 0.01).

Aneurysm↗
PubMed1984

[Clinical experience with methylcobalamin (CH3-B12) for male infertility].

CH3-B12 was administered daily (1,500 micrograms/day, for 4 to 24 weeks) to 26 infertile male patients who visited our clinic from January to December, 1982. It was not administered, however, to patients with azoospermia. Semen analysis was conducted from 8 weeks after the administration of CH3-B12. Sperm concentration increased in 10 cases (38.4%), total sperm counts increased in 14 cases (53.8%), sperm motility increased in 13 cases (50.0%) and total motile sperm count increased in 13 cases (50.0%). Semen volume, however, could not be evaluated due to wide variation. Serum LH, FSH and testosterone were unchanged. Judging by our criteria, 11 cases (42.3%) improved, 11 cases (42.3%) were unchanged and the remaining 4 cases (15.4%) had aggravated.

Adult↗
PubMed1984

[Fusion of opposite visual images by high, medium and low creative groups under response free and response restricted situations].

Two sets each of High, Medium, and Low Creative Groups (HCG, MCG and LCG), N=12 each, were selected on the basis of JARAT (RAT Revised In Japanese) scores from 364 male college students. One set was asked to entitle each of six pairs of superimposed slide photographs in order to assess mental fusion of visual images under Response Free Situation (RFS), and the other set under Response Restricted Situation (RRS). Under RFS, HCG showed significantly stronger propensity for fusing images that had opposite impression than the other groups. MCG and LCG responded to a few images more promptly, while HCG elaborated their responses more than the rest under both response conditions, and especially under RRS in which each group was encouraged to produce excellent ones. Thus, it was suggested that HCG might process opposites more flexibly and reversibly in both remote associative thinking and in homospatial imagery synthesizing.

Adolescent↗
PubMed1984

[Clinical and statistical studies on male infertility and follow-up studies for pregnancy (II)].

Clinical and statistical studies were carried out on 369 infertile male patients who are increasing year by year visiting our clinic during the 3 years from January 1978 to December 1980. If divided into 5-year age groups, the highest frequency occurred in the 30 to 34 year-old age group. In the semen analysis, 23.8% of the patients showed azoospermia, and 48.5% oligozoospermia; the testicular volumes of these patients was generally small. Pathological examinations of their testis revealed germinal cell aplasia or hypospermatogenesis. In the hormonal examinations performed, serum LH and FSH levels in azoospermic and oligozoospermic patients showed a tendency to be higher than normal. Follow-up studies for pregnancy were performed on 242 cases. Among the 108 cases which we were able to study, 30 cases were able to give successful pregnancy, 17 of whom had been treated by clomiphene citrate, 2 by testosterone-clomiphene therapy, and 11 were untreated.

Adult↗
PubMed1983

[A follow-up study on pulmonary functions of workers exposed to various forms of dust. Observation on the workers of pneumoconiosis in Kitakyushu].

Serial spirograms of 121 dust workers whose chest X-rays were found to be "class 1" of the diagnostic criteria for pneumoconiosis were obtained during 1978-80. Yearly changes of pulmonary function variables (%VC, FEV1, FEV1/FVC%,V25/H, and V50/V25) by age, smoking habit, total years of exposure to dust, and work history were evaluated. The average age of the dust workers was 48.0 +/- 5.5 years, and the average years of exposure to dust was 21.6 +/- 6.8 years in 1978. Eighty-two dust workers smoked with the mean smoking history of 24.7 pack-years. No significant differences of spirograms were found between the smoking and non-smoking groups. Among the smokers, however, linear regression of FEV1/FVC% by age gradually decreased during 1978-80. All the pulmonary function variables showed no correlation with smoking history as well as total years of dust exposure. All the dust workers were classified into eight types of work by their histories; crushing and quarrying operators, brick mason, foundry and grinding operators, asbestos workers, underground miners, refractory material workers, pyrites roasters, and welders. The underground miners showed lower FEV1/FVC% and V25 than the average. However, the difference of such pulmonary function variables by eight types of work was not significant by analysis of variance. Since aging is the most dominant factor for pulmonary dysfunction, a longer observation on this group will be needed.

Age Factors↗
PubMed1983

Heterogeneous pathways of Ca2+ metabolism in the triggering of the proliferative process in rat thymocytes.

Concanavalin A induces in rat thymocytes a calcium uptake at 1 h exposure and proliferative response after 24 h exposure. Phosphodiesterase activity parallels the proliferative response (thymidine uptake). Valinomycin, monensin and a small dose of ouabain also induce calcium uptake, but do not lead to thymidine uptake later. The latter treatments reduce, in some instances drastically, the concanavalin A response with respect to thymidine uptake. Trifluoperazine reduces the unstimulated thymidine uptake and the concanavalin A induced thymidine uptake. These results suggest that calcium has a decisive role in inducing proliferation but that some ways of increasing cellular Ca2+ concentration interfere in other steps with the DNA synthesis.

Animals↗
PubMed1983

Teleocidin-induced phenotypic changes in thymic ALL cell line, HPB-ALL.

An indole alkaloid, teleocidin, induced phenotypic differentiation in the thymic ALL cell line HPB-ALL. Within 30 min of seeding in the presence of teleocidin, the cells formed a smooth round shape. Upon 5-day exposure to teleocidin, most of the cells became smaller and reminiscent of large or atypical lymphocytes. A thymic antigen stained with monoclonal antibody OKT6 was remarkably reduced while Leu2a-positive cells were increased in the treated cells. Upon teleocidin-induced phenotypic differentiation, the growth rate of cells was inhibited, their ability to incorporate DNA via [3H]-labelled precursors was reduced, their ability to bind sRBC rosettes was increased. These changes were paralleled to that induced by 12-o-tetradecanoyl-phorbol-13-acetate.

Adolescent↗
PubMed1983

[Field tests of a new passive personal monitor for organic vapors].

The method making use of a New Du Pont PRO-TEKTM G-AA Organic Vapor Air Monitoring Badge, was applied to evaluate the concentration of organic vapor in a working atmosphere. Other methods such as the direct air sampling method and the method of adsorption on charcoal tube were compared with the above mentioned method. In the comparative study of these methods in working places, similar results were obtained by the new badge method and the charcoal tube method, though different results were obtained between the direct air sampling method and the mentioned two methods. The differences may have resulted from the period needed for the sampling, that is, an intermittent sampling was generally used for the direct sampling method. In a study of personal exposure monitoring by the badge method and the tube method, the results obtained by the badge method were lower than those obtained by the latter method suggesting the effects of the response of the badge on organic vapor in working places. The relationships between the instantaneous changes of the concentration of organic vapor in the atmosphere and the response time of the badge will be discussed elsewhere.

Air Pollutants↗