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Biomedical subjects

Y Ando

Publications and source records attributed to Y Ando.

At least 631 records · Page 35Linked to original sources
PubMed1985

[Tissue polypeptide antigen in gynecological cancer].

Serum tissue polypeptide antigen (TPA), CEA and IAP were measured simultaneously in cervical cancer, corpus cancer and ovarian cancer. TPA levels were increased (more than 110 U/1) in 39% (32/82) of the cervical cancer and in 46% (6/12) of the corpus cancer patients, respectively. In ovarian cancer, TPA levels were elevated (146 U/1 or higher) in 64% (13/22). The positive rate of CEA was somewhat lower than that of TPA and LAP levels were as high as TPA. Moreover, TPA levels were correlated in clinical course. In immunohistochemical examination, TPA was present in cancer cells and absent in normal tissue.

Adenocarcinoma↗
PubMed1985

[Reticuloendothelial function as a prognostic factor in breast cancer].

Reticuloendothelial function was investigated in breast cancer by the 131I-microaggregated albumin method using the parameters of phagocytic function (K value) and metabolic function (M value). Reticuloendothelial function of the patients with breast cancer was decreased compared with that of the controls, and it was related to the peripheral lymphocyte count. This finding indicates that reticuloendothelial function is one of the prognostic factors in breast cancer.

Breast Neoplasms↗
PubMed1984

Energy-dependent activation of spore-lytic enzyme precursor by germinated spores of Clostridium perfringens.

A precursor of the spore-lytic enzyme of Clostridium perfringens was extracted with alkali from dormant spores of the organism. The enzyme precursor was activated by incubating it with germinated spores which had been treated with alkali. The activation was greatly enhanced by the addition of 3-phosphoglycerate, suggesting that the conversion of precursor to active enzyme depends on endogenous energy-producing metabolism during germination.

Clostridium perfringens↗
PubMed1984

Patterns of relapse of squamous cell carcinoma of the maxillary sinus.

Ninety-five M0 patients with squamous cell carcinoma of the maxillary sinus were treated mainly with combined surgery, radiation and chemotherapy. They were staged surgically according to the American Joint Committee TNM classification: 3 were T2N0, 55 T3N0, 27 T4N0 and 10 T3-4N1-3 patients. Relapse developed in 66 patients (69%): one (33%), 35 (64%), 22 (81%) and 8 (80%), respectively. All patients experienced relapse within 2 years after diagnosis. Local recurrence developed during the course of disease in 52 (79%) of the 66 patients who relapsed. Three patients with cervical relapse and one with local recurrence were successfully salvaged with rescue surgery. Local control achieved in 39 (41%) of the 95 patients: 2 (67%), 28 (51%), 7 (26%) and 3 (30%) in T2N0, T3N0, T4N0 and T3-4N1-3 patients, respectively. Autopsy findings of 17 patients are presented. An impact of computed tomography on staging of maxillary sinus tumors is discussed.

Adult↗
PubMed1984

Studies of four Japanese families with hereditary angioneurotic edema: simultaneous activation of plasma protease systems and exogenous triggering stimuli.

Forty-five relatives of 4 families with hereditary angioneurotic edema (HANE) were studied. Twenty-five, including 11 asymptomatic kindreds with the disposition, showed typical changes in complement system compatible with HANE. Follow-up study of HANE patients showed that, even in remission period, complement, coagulation and fibrinolytic systems can be activated. During edema attacks, moderate haemoconcentration and neutrophilia were encountered and kallikrein-kinin system was found to be also activated. Replacement therapy with C 1-inhibitor preparation for an edema attack revealed that clinical improvement paralleled the increase in blood levels of high molecular weight kininogen. Thus, HANE attack is considered to be elicited in kindreds with the hereditary disposition by activation of plasma protease systems, particularly by that of kallikrein-kinin system. On the other hand, exogenous triggers that can initiate activation of the protease systems can be classified into 2, neuro-humoral (sympathetic nerve response) and physico-chemical, categories. Hence, the edema attack of kindreds with the hereditary disposition can at least be modified by the biosynthesis of plasma factors and the individual susceptibility to the liberated catecholamines. These two different reaction processes are considered to be linked by the release of plasminogen activator and/or Hageman factor activating enzyme.

Angioedema↗
PubMed1984

Ultrasonography and brain pathology of periventricular hemorrhage and subependymal cyst in the preterm neonate.

Ultrasound (US) findings in 32 premature infants with intraventricular hemorrhages (IVH, 21 cases), subependymal hemorrhages (SEH, 5 cases) or subependymal cysts (SEC, 6 cases) were reviewed to determine the accuracy of US diagnosis and clarify the pathogenesis of SEC. With single US there was the possibility of false-positive or -negative SEH or IVH, but serial US showed diagnostic accuracy for SEH or IVH. Four of 6 cases with iron-negative SEC did not show an image of prior SEH and the SEC suggested focal ischemic microcirculation which may be important in the pathogenesis of the occurrence of SEH or the development from SEH to IVH.

Brain↗
PubMed1984

The role of surface charge in ionic germination of Clostridium perfringens spores.

The surface charge against pH behaviour of spores of Clostridium perfringens type A was determined using a colloid titration method in the pH range 4-9. The native spores as well as various ionic forms of the spores loaded with divalent cations were found to be negatively charged. A positive colloid, MGCh, inhibited the ionic germination of the spores and this inhibition was highly dependent on pH. However, another positive colloid, GCh, did not inhibit the germination. Chemical modification of carboxyl groups on the spore surface by use of a water-soluble carbodiimide with two nucleophiles, glycine ethyl ester and taurine, caused spores not only to have little or no colloidal charge but also to lose the ability to germinate. The modification of carboxyl groups in the spore coat protein also resulted in elimination of, or marked reduction in its negative charge. These results suggest that carboxyl groups in the spore coat protein are the major negatively charged species on the spore surface. The role of surface charge in the ionic germination of the spores is discussed.

Amino Acids↗
PubMed1984

Further characterization of platelet-type von Willebrand's disease in Japan.

We studied four patients who showed aggregation of platelets in platelet-rich plasma at lower concentrations of ristocetin than those required for normal platelet-rich plasma and who demonstrated an increased capacity of the platelets to bind normal von Willebrand factor. The four patients were from two Japanese families. Platelets from one family aggregated spontaneously in vitro, and platelets from both families aggregated upon the addition of normal plasma and cryoprecipitate, in the absence of ristocetin or other agonists. Analysis of the multimeric composition of von Willebrand factor by sodium dodecyl sulfate-agarose gel electrophoresis revealed a decrease in large multimers or a decrease in both large and intermediate multimers in plasma, but normal multimers in platelets. 1-Deamino-[8-D-arginine]-vasopressin caused by an immediate appearance of larger multimers in plasma, followed by the rapid disappearance of these multimers from circulating plasma. Analysis of platelet membrane glycoproteins from the patients showed that there were two distinct bands in the glycoprotein I region; one migrated in a slower region and the other in a faster region than normal glycoprotein Ib. We suggest that the platelet receptor abnormality in these patients is related to this abnormality of glycoprotein Ib.

Deamino Arginine Vasopressin↗
PubMed1984

[An evaluation of antimicrobial removal device to isolate bacteria from bacteremic patients with hematological disorders].

Antibiotics contained in blood specimens often inhibit bacterial growth in culture media. Recently, the antimicrobial removal device (ARD) containing resins to absorb antibiotics has been made available. To evaluate the effectiveness of the ARD, we investigated how much the antibiotics were removed by the ARD. The ARD method was compared to the conventional culturing method in isolating organisms from blood specimens of patients with hematological disorders receiving antimicrobial agents. The antibiotics, including cefotiam, cefsulodin, cefmenoxime, cefazolin and sulbenicillin, were proved to be almost completely removed by the ARD. Bacteria were detected only by use of the ARD in the blood cultures from 2 of 21 blood specimens (11 patients) entered in the study, while all of the blood cultures were negative by the conventional method. These isolated bacteria were S. aureus and P. aeruginosa, of which septicemias were cured by intensive antibiotic therapy for these bacteria. It is suggested that pretreatment with the ARD makes detection of bacteria easier in blood from the patients receiving antibiotics. Literatures were reviewed concerning improvement and shortened time for isolation of organisms by using the ARD.

Adult↗