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X Xing

Publications and source records attributed to X Xing.

82 records · Page 5Linked to original sources
PubMed1994

[The diagnosis of primary hyperparathyroidism--analysis of 134 cases].

This article reports the diagnostic experiences of 134 cases of primary hyperparathyroidism (PHPT) confirmed by operation and pathologic examination. The clinical presentations were divided into 4 types: (1) 75 cases (56.0%) with bone resorption; (2) 47 cases (35.0%) with bone lesions plus urinary calculus; (3) 8 cases (6.0%) with urinary calculus only and; (4) 4 cases (3.0%) with hypercalcemia only. Bone lesions included bone resorption, osteomalacia and osteoporosis. Stones at multiple sites in the urinary tract or nephrocalcinosis were found in 41 cases. The measurement of ionized calcium was much more sensitive and accurate than the total calcium assay with the positive rate of 95.3% and 73.4% respectively. The concentration of plasma iPTH was high in the whole group (n = 84), the mean value was 21.4 +/- 17.9 times higher than that of the normal control group. For the localization of the affected parathyroid gland, instiat examination was by neck ultrasonography which gone a positive predictive value of 81.5% (43/53), 99mTc-MIBI scan showed positive rate 94.1% (16/17). The CT scan of the chest was used when ectopic location in mediastinum was highly suspected. If the first operative exploration failed to find the affected parathyroid gland, we performed the determinations of iPTH with samples taken from internal jugular vein through selective venous catheterization; the coincidence rate was found to be 85.2% (23/27).

Adenocarcinoma↗
PubMed1994

[The preliminary experiences of diagnosis and treatment for hypercalcemia crisis--clinical analysis of 23 cases].

This article report a study of 23 cases of hypercalcemia crisis resulting from primary hyperparathyroidism (18 cases), carcinoma (4 cases) and vitamin D intoxication (1 case). In addition to the symptoms of primary diseases, the patients with hypercalcemia crisis often had anorexia, nausea, vomiting, polydipsia, polyuria, psychoneurotic symptoms, arrhthmia. The severity of the symptoms was proportional to the degree of hypercalcimia. Serum calcium concentration of patients in hypercalcemia crisis should be equal or higher than 3.75 mmol/L (15 mg/dl) or serum ionized calcium higher than 1.88 mmol/L. Treatment hypercalcemia crisis consisted of rapidly lowering the serum calcium level by various measures while actively treating the primary diseases. Our experience is to supply normal saline intravenously or orally to increase the extracellular fluid and to enhance excretion of the urine calcium by administrating furosemide. In this paper, serum calcium concentration of 5 patients with hypercalcemia crisis treated with salmen calcitonin was reduced in varying degrees. The above mentioned treatment would be beneficial to the alleviation of the crisis and the preparation for operative treatment.

Acute Disease↗
PubMed1994

[Experimental studies on microcirculation of the hindlimb after ischemia and reperfusion in the rabbits. 1. Establishment of an in vivo method for observing microcirculation using tendon surface microvessels on the dorsum of the foot].

The blood supply system of the extensor digitorum longus tendon in the rabbit hindlimb is observed by the aid of dye injection technique and dissecting microscope. We find that the segment proximal to metatarsophalangeal joint of this tendon is an ideal site for observation of in vivo microcirculation. In this site, there are abundant microvessels on the surface of the tendon, and as red microvessels are on white tendon, it forms a sharp contrast. In addition, the tendon is only covered by skin and little loose connective tissue, so it is easy to expose. On the bases of abovementioned findings, a new in vivo method for observing microcirculation in the rabbit hindlimb is developed. In our experiences, the advantages of this method are as follows: (1) It is simple and convenient; (2) The time required for preparation is short (about 10-15 min), and the observation period can be extended (over 6 h.); (3) Surgical trauma is not serious; (4) The image is clear. This method opens up a new way to using rabbit hindlimb ischemia model to study microcirculation changes in vivo following reperfusion after extremity ischemia.

Animals↗
PubMed1993

[Comparative study on tissue morphology and vascular changes of skin xenografts, allografts and autografts after transplantation].

In this study, the tissue morphology and the vascular changes of skin xenografts from the rats to the rabbits were compared with that of skin allografts and autografts simultaneously transplanted to the same recipient by the use of histological examination and dye injection. The results suggested that the xenografts were incapable of becoming vascularized, and exhibited necrosis on the third day, while early vascularization was demonstrated in the allografts and autografts. The xenografts underwent a course of "white graft rejection", which probably contributed to rejection.

Animals↗
PubMed1993

[Transsexualism].

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Disorders of Sex Development↗
PubMed1989

[Comparative study of the transplantation of vascular pedicle and traditional free tendon tissues].

The most frequent cause of failure after tendon transplantation is the formation of adhesions between the tendon graft and its surrounding tissues. In this study, the healing mechanism, adhesion formation and biomechanical properties of vascular pedicle and traditional free tendon grafts were compared in the rabbits. It was observed that the former remained normal histologically in healing process and had less adhesion formation; that of the latter underwent necrosis and was gradually replaced by new connective tissues, its adhesions were extensive and dense; and that the healing mechanism of the both tendon grafts at the anastomosed site were extrinsic, the biomechanical properties (rupture load and elastic stiffness) showed no statistically significant difference (P greater than 0.05). On the basis of these results, we believe that preserving of the blood supply of tendon graft is important for reducing the adhesion formation and improving the functional results.

Animals↗
PubMedDate not supplied

Mutant SV40 large T antigen as a therapeutic agent for HER-2/neu-overexpressing ovarian cancer.

The HER-2/neu gene is frequently amplified and/or its protein product, p185, is overexpressed in a number of human cancers. Overexpression of p185 correlates with poor prognosis and low survival rates in ovarian cancer patients. We previously found that the K1 mutant of SV40 large T antigen inhibits rat neu promoter and suppresses mutation-activated rat neu transformation in mouse fibroblasts. We show here that K1 also inhibits human HER-2/neu promoter in human ovarian cancer cells. To investigate whether K1 can suppress HER-2/neu transformation and thus is a potential therapeutic agent, we used an orthotopic ovarian cancer model in which mice were injected intraperitoneally with HER-2/neu-overexpressing human ovarian cancer cells to induce tumor development. The tumor-bearing mice were then treated with K1-liposome complex weekly. We found that liposome-mediated K1 gene transfer decreased the p185 protein level by K1 expression in these cancer cells and significantly prolonged mice survival; about 40% of these treated mice were alive for more than 1 year without any tumor development. On the other hand, the animals from control groups that did not receive this gene therapy all developed tumors and died within 7 months. The results indicate that liposome-mediated K1 gene transfer is able to suppress tumor development from HER-2/neu-overexpressing ovarian cancer cells in mice.

Animals↗