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Biomedical subjects

X Jing

Publications and source records attributed to X Jing.

47 records · Page 3Linked to original sources
PubMed1995

[Confocal laser scan microscope system and its applications on studying acupuncture and meridian].

In this paper, the principle of a confocal laser scan microscope system and its advantages are introduced. Its applications in biology and research of acupuncture and meridian are also introduced. Compared with conventional microscope, the confocal laser scan microscope system has many advantages such as high resolution fluorescent image, 3-dimension reconstruction, images quantitative analysis of concentration of ion within a cell, cell-cell communication and so on. It will offer many mathods for researching acupuncture and meridian.

Acupuncture Therapy↗
PubMed1994

An epidemiological study on the relationship of ectopic pregnancy and the use of contraceptives in Beijing--the incidence of ectopic pregnancy in the Beijing area. Beijing Collaborating Study Group for Ectopic Pregnancy.

The incidence of ectopic pregnancy (EP) was studied through a 3-level monitoring network of maternal and child health care (MCH) in the entire Beijing area, including 82 hospitals, 19 MCH centers and 2 institutes for family planning. A total of 1,420 cases of EP were collected in a sample of 2.7 million women of reproductive age (15-49) during a one-year period from January 1 to December 31, 1990. The cases were confirmed by pathological examination or laparoscopy. In addition, epidemiological surveillance method was used. The results showed that the overall incidence of EP was 0.52 per thousand women of reproductive age (W = Women of reproductive age (15-49)) in the Beijing area, 0.6/1000W in the urban districts and 0.41/1000 in the rural area; 0.67/1000W married women, and 0.05/1000W in the unmarried. For married women, 0.54/1000W for those women using various contraceptive measures and 1.80/1000W for women using no contraceptives. The incidence of EP varies with different contraceptive methods. Female sterilization had the lowest incidence (0.18/1000W) and natural contraceptive measures (rhythm or withdrawal method) had the highest (2.43/1000W). It was 0.65/1000W in IUD users, 0.21/1000W in OC users and 0.57/1000W in couples using condoms or spermicides.

Adolescent↗
PubMed1992

Quantitative risk assessment for lung cancer from exposure to metal ore dust.

To quantitatively assess risk for lung cancer of metal miners, a historical cohort study was conducted. The cohort consisted of 1113 miners who were employed to underground work for at least 12 months between January 1, 1960 and December 12, 1974. According to the records of dust concentration, a cumulative dust dose of each miner in the cohort was estimated. There were 162 deaths in total and 45 deaths from lung cancer with a SMR of 2184. The SMR for lung cancer increased from 1019 for those with cumulative dust dose of less than 500 mg-year to 2469 for those with the dose of greater than 4500 mg-year. Furthermore, the risk in the highest category of combined cumulative dust dose and cigarette smoking was 46-fold greater than the lowest category of dust dose and smoking. This study showed that there was an exposure-response relationship between metal ore dust and lung cancer, and an interaction of lung cancer between smoking and metal ore dust exposure.

Adult↗
PubMedDate not supplied

Cloning and characterization of Hepp, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells.

Through differential screening of mouse hematopoietic stem cell (HSC) and progenitor-subtracted cDNA libraries we have identified a progenitor cell-specific transcript that represents a novel gene, named Hepp (hematopoietic progenitor protein). The mouse Hepp gene encodes a protein of 237 amino acids with no detectable known functional domains or motifs. Lack of invertebrate orthologs and a high degree of evolutionary conservation of the peptide sequence in vertebrate species (zebrafish, mouse, human) suggest that the Hepp gene could have conserved although as yet unknown function in vertebrates. Mouse Hepp shows a restricted expression pattern in adult tissues and is transcribed at a very low level in heart, lung, spleen, and thymus and at a higher level in muscle. During embryonic hematopoiesis Hepp is not expressed in mouse fetal liver HSC (Sca-1(+)c-kit(+)AA4.1(+)Lin(-) cells), but is abundantly transcribed in the population of hematopoietic progenitors (AA4.1(-) cells). Similarly, during adult hematopoiesis Hepp is not transcribed in the highly enriched population of bone marrow HSC (Rh-123(low)Sca-1(+)c-kit(+)Lin(-) cells), but its expression is upregulated as a greater heterogeneous population of bone marrow HSC (Lin(-)Sca-1(+) cells) differentiates into progenitors (Lin(-)Sca-1(-) cells) and more mature lymphoid and myeloid cell types. A restricted pattern of expression in adult tissues and preferential expression in both fetal and adult hematopoietic progenitors and mature blood cells suggest that Hepp could be involved in molecular regulation of HSC and progenitor cell lineage commitment and differentiation.

Animals↗
PubMedDate not supplied

The effects of diazepam dependence and withdrawal on morphine-induced antinociception and changes in locomotion in male and female rats.

Male and female rats were exposed for 3 weeks to diazepam (DZ)-filled or empty capsules (CTR) prior to the daily administration of morphine (MOR, 5 mg/kg, IP) for 5 days. Thereafter, capsules were removed and 48 h later MOR was injected for the next 5 days. The tail-flick latency (TFL) was measured prior to and 15, 30, and 60 min after MOR assessed analgesia. Locomotion (LOC) was determined before and 15 min after injection. Prior to MOR injection (baseline), male rats were more sensitive to the thermal stimulus and were less active than female rats. Daily MOR injections neither affected the baseline TFL nor LOC. Regardless of gender, MOR produced greater analgesia in DZ-dependent and withdrawn rats than in CTR. MOR analgesia was greater in DZ-dependent male than in female rats. Gender differences in MOR analgesia were not of statistical significance in DZ-withdrawn rats. The first dose of MOR produced more depression of LOC in DZ-dependent female than in male rats. Across the time of MOR injections, female DZ-dependent and withdrawn rats were less active than CTR. LOC increased with repeated administration of MOR in all groups of rats. In summary, DZ dependence and withdrawal enhanced MOR analgesia in rats of both sexes. Regardless of chronic treatment, MOR produced more analgesia and less depression of LOC in male than in female rats. It is suggested that a decrease in the function of the GABAergic system plays a role in alteration of MOR analgesia.

Analgesics↗