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Biomedical subjects

W Wolf

Publications and source records attributed to W Wolf.

At least 163 records · Page 9Linked to original sources
PubMed1980

[Noninvasive possibilities of X-ray diagnostic on prostetic heart valves (author's transl)].

Characteristic mechanical qualities and possibly occurring complications are discussed in this paper. Noninvasive x-ray diagnostic with chest radiographex, fluoroscopy and 70mm camera makes possible an exact identification of any prosthetic valve. If there is any clinical suspicion, negative x-ray findings will not exclude malfunction of the prosthesis. Invasive diagnostic proceeding is necessary in such cases.

Fluoroscopy↗
PubMed1979

[Sensitivity of the haemoccult test in colorectal tumours (author's transl)].

157 patients with histologically investigated colorectal tumours from 5 hospitals of the University of Munich were tested with the Haemoccult test. In 30 (35.7%) of 84 patients with malignancy of the colon and in 31 (58.5%) of 53 patients with adenomas or polyps the correctly performed test was negative. The test result showed no dependency on age or sex of the patient, nor on size, stage or localisation of the tumour. A problem-orientated history lowered the rate of false negative tests to 2.4%. The high rate of false negative results was not attributable to organisational or technical errors.

Adenoma↗
PubMed1977

Preparation and high-performance liquid chromatography of iodinated diethylstilbestrols and some related steroids.

Diethylstilbestrol and estradiol have been converted to their mono- and poly-iodinated derivatives by electrophilic substitution of positive iodine into the activated aromatic rings. Both chemical and electrochemical procedures have been employed for the iodination, and the latter procedure proved to be superior. These iodinated derivatives have been purified by preparative high-performance liquid chromatography, and characterized by ultraviolet and mass spectroscopy.

Chemical Phenomena↗
PubMed1977

A model for prediction of chemotherapy response to 5-fluorouracil based on the differential distribution of 5-[18F]fluorouracil in sensitive versus resistant lymphocytic leukemia in mice.

The distribution of 5-[18F]fluorouracil has been compared in two variants of the same tumor in c57bL X DBA/2 F1 mice: solid L1210 lymphocytic leukemia tumor susceptible to 5-fluorouracil treatment and the same tumor, made resistant to the drug over a 34-generation span. Significant differences in 5-[18F]fluorouracil distribution were observed, most notably in the tumor:blood ratios at 12 hr postinjection. The drug-responsive tumor showed a 20:1 concentration ratio, whereas the drug-resistant tumor only had a 4:1 concentration ratio. We postulate that these differences, observed here in this animal tumor model, may be a reflection of similar ratio differences in humans. This technique may allow, by noninvasive quantification of tumor:blood ratios following administration of 5-[18F]fluorouracil to man, the differentiation of those human tumors that are likely to respond to drug therapy from those in which the response will be minimal or nil.

Animals↗
PubMed1977

[Rapid healing of a chronic drainage fistula after nephrectomy using the paragalalith technic (tissue adhesive)].

The paragalalith technique satisfied the expectations as method of treatment for the obliteration of a fistula also in an incomplete 12 cm long nephrectomy fistula in a 61-year-old patient. More than 13 months this drainage fistula resisted to every other conservative measure. During 2 weeks we achieved a gradual obliteration of the fistula by a filling of the fistula with the subtrate developed by us performed five times. This method for the obliteration of the fistula we applied successfully in closing more than 30 different fistulae in the abdominal and anogluteal region.

Chronic Disease↗
PubMed1977

Urinary chromium excretion and atherosclerotic manifestations in two Finnish male populations.

The urinary exretion of chromium was studied for relationships to atherosclerotic diseases in two rural Finnish male populations, aged 55 to 74; one from eastern Finland, the other from the southwestern part of the country. A 10-year follow-up had shown a particularly high mortality from coronary heart disease in the eastern area where the concentrations of chromium in the drinking water were lower than in the western area. The 24-hr urinary excretions of chromium of the two populations were markedly low (east, mean +/- SEM, 3.60 +/- 0.15 microgram; west, 3.74 +/- 0.13 microgram), suggesting a suboptimal chromium intake in both populations. No consistent differences were found in urinary chromium excretions between groups with atherosclerotic diseases and reference groups. The role of low chromium intake in the pathogenesis of atherosclerosis deserves further study.

Aged↗