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Biomedical subjects

W Wohlrab

Publications and source records attributed to W Wohlrab.

At least 73 records · Page 4Linked to original sources
PubMed1986

Liposome-bound cortisol: a new approach to cutaneous therapy.

Preparation and applicability of liposome-bound cortisol as a drug delivery system for cutaneous administration of glucocorticoids have been investigated. With the liposomal drug a very much improved concentration-time profile was obtained in the different layers of human skin when compared with conventional cortisol in the ointment. The pronounced carrier ability of liposomes for cortisol in the skin holds promise for an increase in its therapeutic efficiency, while at the same time reducing unwanted systemic side effects of the topical glucocorticoid therapy.

Administration, Topical↗
PubMed1984

The influence of urea on the penetration kinetics of topically applied corticosteroids.

The effect of urea on the penetration of hydrocortisone and triamcinolone acetonide into human skin from topically applied vehicles was studied. The resulting penetration promotion has two possible applications in topical therapy: (a) An increased therapeutic effect for a given concentration of the active constituent. (b) A given therapeutic effect could be obtained with a reduced concentration of the active ingredient.

Administration, Topical↗
PubMed1984

[Relation of the vehicle to urea penetration in human skin].

Prerequisite to any efficiency of urea in the skin is its penetration into the different skin layers. In addition to the differences in the reactivity of the skin, the ointment base is the most important factor for the intensity and the course of urea penetration. For the penetration of urea into the human skin a strong vehicle dependence can be proved. On the basis of a different penetration kinetics of urea from O/W and W/O emulsions, various efficiencies can be deduced with regard to the penetration promotion of drugs or the increase of the water-binding capacity of the horny layer. The significance of these findings for the use of urea in the external therapy is being discussed.

Humans↗
PubMed1984

[Penetration kinetics of potential virustatics into the human skin].

Caffeic acid oxidation product (KOP), a substance effective against various human viruses, penetrates quickly from a 1% W/O-emulsion into the skin and forms a reservoir in the horny layer. In the epidermis and dermis approximately 30 min after external application KOP concentrations of 1 to 3% of the applied total quantity are achieved, which remain nearly unchanged even after longer penetration time. In addition to references for therapy derivable from this the results permit to draw conclusions about drug resorption that can be proved in animal experiments under in-vivo conditions.

Antiviral Agents↗