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Biomedical subjects

W Wiest

Publications and source records attributed to W Wiest.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Bacteriological examination of amniotic fluid after intra-amnial tocometry sub partu (author's transl)].

Two sets of group of 50 women were examined and compared to find out if the introduction of continuous intra-uterine catheter during labour increased infection. Amniotic fluid was withdrawn from both groups and examined. Also a catheter was introduced into the amniotic sac of one group and after 2 and 5 hours amniotic fluid was also withdrawn from both groups and examined. Inhaled amniotic fluid from the infant was also withdrawn and bacteriologically examined both quantitatively and qualitatively. The examination proved that there was no significant increase in the infection of the test group and the control group. Also there were no complications observed on the mother and child after delivery.

Adult↗
PubMed1979

[Serum ribonuclease activity in patients with gynaecologic malignomas (author's transl)].

The aim of our work was to evaluate the diagnostic value of the determination of the ribonuclease activity in sera of patients with gynaecologic malignomas. We therefore developed an assay for ribonuclease activity. In the course of optimization of the assay conditions we investigated the applicability of 4 commercially available RNA-preparations as substrate and the dependency of the ribonuclease activity on salt-concentration. The ribonuclease activity of 42 representative female patients (12 controls, 11 with ovarian carcinoma, 10 with corpus carcinoma, 9 with collum carcinoma) is presented.

Adult↗
PubMed1978

[The effects and side-effects of the intra-cervical application of prostaglandin F-2 alpha during early pregnancy (author's transl)].

In order to avoid the traumatic dilatation of the cervix for therapeutic abortions 200 micrograms of prostaglandin F-2 alpha were injected into the cervix. The effect on dilatation of the cervix was compared with the injection of normal saline in the control group. Without side effects the injection of prostaglandin F-2 alpha resulted in dilatation of the cervix and softening of the cervix. Normal saline had no effect. At present it is unknown whether the dilatory effect of prostaglandin F-2 alpha on the cervix is local or secondary to uterine contractions.

Abortion, Legal↗
PubMed1977

[The influence of beta-sympathomimetics and so-called Ca++-antagonistic inhibitors on human heart muscle in vitro (author's transl)].

In an in vitro assay on fetal human heart muscle it was demonstrated for the first time that overstimulation by beta-sympathomimetics could cause elective parenchymal necrosis. Fenoterolhydrobromide, which is used for tocolysis on a longterm scale, induces in vitro necroses of individual heart muscle fibers according to a pathogenetic principle postulated by Flekkenstein. The combination of Fenoterolhydrobromide with a Ca++-antagonist prevents elective parenchymal necroses by reducing the Ca++-influx into the heart muscle fibers. These results suggest that elective necroses of heart muscle fibers may be not only of coronarogenic but also of metabolic origin.

Calcium↗
PubMed1976

[Potassium substitutes during tocolysis].

The level of serum potassium during tokolytic therapy with Partusisten and Isoptin decreases in the first 24 hours of therapy. This decrease is not due to an increase in renal potassium elimination. During tokolytic treatment the serum level of potassium returns to its normal value after 48 hours without potassium substitution. While there is a decrease in serum potassium noticeable changes in electrocardiogram which are typial for hypopotassemia are observed. These changes disappear afer 48 hours of tokolytic treatment but never the less the initial serum potassium drop should be balanced by potassium substitution within these 48 hours.

Adrenergic beta-Agonists↗
PubMed1976

The effects of betamimetic drugs used for tocolysis on the fetal myocardium.

During the last five years tocolysis with betamimetic drugs, e.g. Fenoterol has become a standard method for the treatment of impending premature births. We studied the effect of Fenoterol in vitro on organ cultures of human fetal hearts. At a concentration in the nutrient medium corresponding to the dose used in clinical application, light and electron microscopy demonstrated myocardia damage. In contrast the combined use of Fenoterol and the calcium antagonist Verapamil in a ratio of 1:40 showed no pathological findings either clinically or in vitro. The results are documented with light and electron photomicrographs.

Ethanolamines↗
PubMed1976

[Changes in blood coagulation and thrombocyte aggregation during extended inhibition of labor (author's transl)].

The influence of extended tocolysis with Partusisten on blood coagulation was examined in 30 patients at various times during pregnancy. A rapid and statistically significant reduction of thrombocyte aggregation was found in all examined parameters. The effect was independent of the method of administering the medicine and continued during the whole period of time examined. Values, with which an increased tendency toward hemorrhage could be expected, did not occur. The values possibly reflect an increased disaggregation of the thrombocytes. The decreased whole blood viscosity with an unchanged hematocrit could also improve placental perfusion and, thereby, the nourishment of the fetus. All examined parameters of plasmic coagulation remained normal. No signs of a hypercoagulability or an increased fibrinolysis were present.

Blood Coagulation↗
PubMed1976

[Changes in maternal cardiovascular parameter during tocolysis and in the dorsal position shock syndrome (author's transl)].

Maternal circulatory parameters and fetal heart rate were measured in 25 healthy pregnant women in the last trimenon during treatment with Fenoterol, Fenoterol in combination with Verapamil and Verapamil alone. Dosages were used in accordance with the tocolytic guidelines from Weidinger and Wiest. We were able to demonstrate that the betamimetic Fenoterol alone and in combination with the Ca++-antagonist Verapamil strongly increases the maternal heart rate an the maternal cardiac output whereas the peripheral resistance decreases accordingly. The average blood pressure stayed leveled, so that a decreased uterine blood flow cannot be assumed under betamimetics from the maternal cardiovascular point of view. However, there are indications for an increased placental blood flow during tocolysis. The betamimetic drug show no significant effect on the fetal heart rate. Additional application of the Ca++-antagonist Verapamil during tocolysis with Fenoterol (in dosages usually used for tocolysis) doesn't change cardiovascular reactions caused by Fenoterol. Change in position from supine to left lateral position caused a short term increase in the maternal cardiac output even noted in pregnant women without a clinically observed cavasyndrom. These changes of maternal cardiac output are comparable with those in orthostatic stress situations.

Adult↗