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W Wiest

Publications and source records attributed to W Wiest.

At least 19 recordsLinked to original sources
PubMed1987

Ovarian carcinoma: increase in clinical validity by simultaneous determination of SRA and CA 125.

Ovarian carcinomas are distinguished by their polyclonality, i.e., heterogeneity and polymorphism of their tissue. There is no marker available complying with the clinical demands in the case of ovarian carcinoma regarding satisfactory sensitivity and specificity. Therefore, we have simultaneously determined two entirely distinct tumor markers, serum ribonuclease activity (SRA) and cancer antigen 125 (CA 125), recommended in the literature with respect to ovarian carcinoma. After evaluation by logistic regression analysis, we found a specificity of 93% together with a sensitivity of 97% for the simultaneous determination of SRA and CA 125 (37 ovarian carcinomas, 11 cases without pathological findings after treatment, 11 benign tumors of the ovary, 61 controls). The patients are not exposed to increased stress by this simultaneous determination method compared to the determination of a single marker. The increased clinical validity justifies the recommendation of routine simultaneous determinations of SRA and CA 125 for diagnosis and monitoring of patients with ovarian carcinoma.

Antibodies, Monoclonal↗
PubMed1987

[Induction of fetal lung maturation using ambroxol and betamethasone. Results of an open multicenter study].

In a randomized open multicenter study the results of antenatal prophylaxis against neonatal RDS by administration of betamethasone were compared with those obtained with the bromhexine VIII metabolite Ambroxol. Ambroxol was administered for a maximum of 5 days - 1000 mg in an infusion solution; betamethasone was injected intramuscularly in 2 daily doses of 8 mg. One of these two substances was given to 123 pregnant women for pulmonary maturation in the fetus, in accordance with a randomization plan. The patients were either being treated for premature labor or pregnancy was terminated on the basis of indication between the 28th and 36th week. Therapy had to be discontinued in 4 cases in each group, because of continued labor and birth, and in one case because of an amniotic infection syndrome. A full analysis of the treatment records of 57 pregnancies in the Ambroxol group was carried out; the corresponding figure for the betamethasone group was 58. In 39 patients the duration of pregnancy was 37 weeks or more, so that no assessment on the basis of neonatal pulmonary maturity was possible. In the remaining pregnancies, RDS morbidity was estimated on the basis of clinical and radiological findings and blood gas analysis. Related to a maximum duration of pregnancy of 34 weeks, RDS morbidity after Ambroxol therapy was 18.2% (2 out of 11), as opposed to 35.7% (5 out of 14) after betamethasone treatment. The results confirm that antenatal administration of Ambroxol can bring about a reduction in neonatal RDS corresponding to that achieved with betamethasone therapy. However, with Ambroxol the occurrence of side-effects is potentially lower; it therefore has advantages over betamethasone while being equally efficacious.

Ambroxol↗
PubMed1987

[Toxic shock syndrome toxin-1 producing strains of Staphylococcus aureus in vaginal smears].

21 Staphylococcus aureus strains were isolated from 391 vaginal swabs. This corresponds to a frequency of 5.3%. In females using tampons this frequency was 7%, in users of napkins 2.4%. 2 out of these 21 S. aureus strains produced toxic shock syndrome toxin-1 (TSST-1). Both strains originated from women using tampons. Therefore, 5 out of 1000 women must be expected to carry TSST-1-producing S. aureus strains within their vagina.

Adolescent↗
PubMed1986

[Effect of subpartal tocolysis on maternal cardiovascular parameters with subsequent cesarean section in general anesthesia].

The influence of subpartal beta-sympathicomimetic tocolysis on a subsequent Caesarean section with halothane as inhalational anaesthetic was examined in 42 pregnant women. Alterations in the heart rate, blood pressure and heart action during the operation were measured. 23 patients (group "bolus") received fenoterol monotherapy. In 19 patients (group "iv-tocolysis") fenoterol was combined with the cardioselective beta-1-blocking agent metoprolol. In comparison with these two groups, 25 pregnant women without tocolysis were examined as controls. There were only slight differences in heart rate and blood pressure between the three groups. Arrhythmias were registered in 42 percent of the cases, in most cases during light anaesthesia before delivery. Sinus tachycardias with a heart rate of 130 beats per minute or more were observed most frequently. Arrhythmias of ectopic origin and sinus bradycardias, however, were found seldom. The incidence of arrhythmias in the three groups during Caesarean section did not differ significantly. There was no evidence for an increased occurrence of arrhythmias following beta-sympathicomimetic tocolysis.

Adult↗
PubMed1986

Serum ribonuclease activity in patients with ovarian tumors.

The RNase activities have been assayed in 1678 serum samples from a total of 209 patients. 52 with histologically confirmed ovarian carcinoma, 13 with benign tumors of the ovary, and 144 patients without any clinically detectable malignancy. The serum RNase activity is unequivocally increased in the group with ovarian cancer (p less than 0.01). Considering the distribution of the RNase activities with a margin at 300 ngeqvs/ml serum we find 8.3% false negative and 4.9% false positive results. The serum RNase activity does not display any evident relationship with tumor spread, histology, clinical grading (TNM), nor metastasis at the time of the blood taking. It is concluded that the serum RNase activity is a meaningful criterion together with the careful clinical examination for the diagnosis and the surveillance of ovarian cancer.

Aged↗
PubMed1985

[Cost-benefit studies of 2 equivalent forms of therapy in cervical cancer in the pretherapeutic T 1b stage].

Patients suffering from a collum carcinoma stage T 1b can be treated either by operation according to Wertheim and Meigs, or by radiotherapy. The results with regard to post operationem complications, five-year-survival and recidivation are equivalent in both methods. Therefore, an analysis of the indirect benefit and the costs of both therapies was performed. Surgery was superior to radiotherapy in all analysed dimensions of indirect benefit. Over and above this, expenses for an operation were 2.7 times lower than for radiotherapy.

Adult↗
PubMed1985

Biliary concentrations of temocillin.

Serum and bile concentrations of temocillin were measured after intravenous administration of 1g twice daily to 16 patients with biliary tract infections. The concentration of temocillin in the bile showed high inter-individual variations; however, in patients drug concentrations were attained which were considerably higher than the minimum inhibitory concentrations of the biliary tract pathogens identified throughout the study period. All the patients admitted to the study were treated successfully by temocillin, with the tolerance of the drug being very good, and no side effects or drug-related deteriorations of laboratory data being reported.

Adolescent↗
PubMed1984

[Peridural morphine analgesia for the control of tumor-induced pain in gynecologic cancer patients].

22 gynecological patients suffering from considerable tumor pain in an advanced carcinoma stage had a continuous peridural anaesthesia. 18 patients reported a very good and 4 patients a sufficient analgesia. The average morphine dose per day was 14 mg. The indwelling catheters remained on an average 27 days in site. Side effects, which could be related to the morphine PDA, occurred in one case.

Catheters, Indwelling↗
PubMed1984

Determination of ribonuclease activity in the serum of ovarian carcinoma patients.

Increased serum ribonuclease activity represents a phenomenon of ovarian carcinoma. We have developed a convenient sensitive and reproducible assay system to determine the ribonuclease activity in human serum. The influence of various factors and conditions like storage, pH, salt, heparin, and the accuracy of the determination of HSRA was investigated.

Adult↗
PubMed1983

[Premature birth. Retrospective study of 2000 premature births at the Gynecological Clinic of the University of Mannheim. 2: Postpartum period, morbidity and mortality of premature infants].

During a period from 1966 to 1977 a retrospective study on 1982 premature births was conducted. 9,4% of the premature births were dead born; from the births, who died in the postnatal period, 94% died within the first 7 days, perinatal mortality was 27%. Most common cause of death was immaturity (25%), followed by respiratory distress syndrome (16%), in 31% cause of death was unknown. The most common complications of the immature births were icterus neonatorum (25,3%), aspiration (21,3%) and asphyxia (8,9%).

Female↗
PubMed1981

Control of mineral homeostasis during lactation: interrelationships of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone, calcitonin, prolactin, and estradiol.

To further define control of mineral homeostasis during lactation, 28 lactating (L) and 20 nonlactating (NL) women were studied at 6 weeks post partum. Serum and urine calcium, magnesium, and phosphorus were normal and the same in both groups. 25-Hydroxyvitamin D (25-OHD) was the same (L, 18.6 +/- 4.8; NL, 17.0 +/- 5 ng/ml) in spite of a twofold higher intake of vitamin D in the lactating group. The serum fractions containing 24,25-dihydroxyvitamin D (24,25(OH)2D) were lower than in nonpregnant adults in both groups but significantly lower (P less than 0.05) in lactating than in nonlactating women (L, 1.67 +/- 1.7; NL, 2.46 +/- 1.3 ng/ml). 1,25-Hydroxyvitamin D (1,25-(OH)2D) was normal in both groups (L, 25.8 +/- 8.6, NL, 31.8 +/- 8.1 pg/ml). Parathyroid hormone (PTH) was normal in both groups (L, 5.6 +/- 2.0; NL, 7.2 +/- 1.9 microliters Eq/ml), and calcitonin (HCT) was equally detectable. As expected, prolactin was higher in the lactating group (L, 46 +/- 36; NL, 14.3 +/- 14.9 ng/ml). Serum prolactin levels had no correlation with serum 1,25(OH)2D. Estradiol was significantly (P less than 0.02) lower in lactating women (L, 78 +/- 23; NL, 105 +/- 28 pg/ml). One could speculate that the lower levels of estradiol in the presence of low 24,25(OH)2D and normal HCT allow bone resorption to occur at a rate adequate to supply the mineral needs of lactation without elevations of either PTH or 1,25(OH)2D.

24,25-Dihydroxyvitamin D 3↗
PubMed1981

[A report about 311 ovarian carcinomas, treated at the "Universitäts-Frauenklinik des Klinikums Mannheim der Universität Heidelberg" from 1960--1978 (author's transl)].

In the medical histories no hints could be found, suggesting a definite risk-group for ovarian carcinoma. Symptoms and complaints are often uncharacteristic and no methods for early recognition are known. The therapy of the ovarian cancer is an operation, combined with chemotherapy, or radiation considering to the stage of the tumour. Most important for the prognosis is the degree of expansion, besides age of the patients and the histological pattern of the tumour. The three-years-survival rate of our patients with stage T1 is 71,7%, and with stage T4 only 13,5%. Above all advance in early diagnosis it is necessary to achieve higher survival rates.

Adolescent↗