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Biomedical subjects

W Weiss

Publications and source records attributed to W Weiss.

At least 145 records · Page 8Linked to original sources
PubMed1986

[Therapy of duodenal ulcer and pyloric ulcer with 800 mg cimetidine nightly].

The efficacy of cimetidine 400 mg b.i.d. as compared with a single evening dose 800 mg was evaluated in a single-blind multicentre trial involving 86 patients with endoscopically proven duodenal or pyloric ulcer. After four weeks of treatment the healing rates were 64.4% (29/45) with 400 mg cimetidine twice daily and 78% (32/41) with 800 mg nocte; after eight weeks the corresponding rates were 77.7% (35/45) and 85.3% (35/41). Administration of 800 mg cimetidine every evening is, consequently, at least as effective as a twice-daily regimen. In the second half of the treatment period it was significantly more effective in reducing pain and antacid consumption. The single noctural dose takes the pathogenetic importance of overnight gastric acidity into consideration, entails a simplification of therapy and may improve patient compliance. It should, therefore, take preference over the conventional twice-daily regimen.

Adolescent↗
PubMed1985

[Social representations of alcohol in children and adolescents].

Two hundred (200) pupils, aged 7-8, 12-13, and 16-17, sampled in different schools in the city of Lausanne, were interviewed for a study financed by the Swiss Foundation for Scientific Research. The Characteristic contents and structure of social representations about alcohol, tobacco, and illegal drugs were investigated by means of a semi-qualitative, personal interview. Results concerning alcohol show that within a relatively short span of time adolescents assimilate a great deal of knowledge about alcohol's functions, effects and the meaning of consumption available in a given cultural context. Furthermore, perceived social expectations, derived from the observation of consumption patterns and models, proved to be decisive with regard to intentions for future behavior.

Adolescent↗
PubMed1985

Evaluation of the in-vitro antibacterial activity of Sch 34343.

The in-vitro activity (as measured by geometric mean MICs, mg/l) of Sch 34343 against aerobic and anaerobic bacteria was compared with that of 14 other selected beta-lactam antibiotics including aztreonam, latamoxef (moxalactam), ceftazidime and imipenem. Sch 34343 had good activity (less than 2 mg/l) against most Gram-negative aerobic bacteria whether or not they contained high levels of plasmid-mediated or chromosomally-mediated beta-lactamases. It was slightly less potent against strains of Morganella and Serratia (less than 4 mg/l) and inactive against Pseudomonas (greater than 64 mg/l). A very small inoculum effect was observed against strains containing beta-lactamases indicating stability. Unlike the third-generation cephalosporins, Sch 34343 had excellent activity (less than or equal to 0.18 mg/l) against staphylococci, comparable to that of imipenem and ampicillin. While Sch 34343 had equally good potency (0.17 mg/l) against penicillinase-positive staphylococci, it was inactive against methicillin-resistant staphylococci (greater than or equal to 35 mg/l). Sch 34343 also had good activity against streptococci. The most unusual aspect of the in-vitro activity was its activity against Bacteroides (including Bact. fragilis) and other anaerobes. Sch 34343 had mean MICs less than or equal to mg/l for all Bacteroides and Clostridium spp. tested except CI. difficile (3.4 mg/l).

Anti-Bacterial Agents↗
PubMed1984

The shared field: a precursor stage in the development of a psychotherapeutic alliance with the hospitalized chronic schizophrenic patient.

Psychotherapeutic work with chronic schizophrenic patients is difficult for both patient and therapist. Such patients lack many of the capacities necessary to participate in psychotherapy: motivation, observing ego, the ability to communicate verbally about thoughts and feelings, the capacity to sustain a relationship. Treatment of such patients may require phases in which such capacities are nurtured until the patient is able to form a therapeutic alliance of the ordinary kind. This paper discusses the ways in which hospitalization can be helpful during pre-alliance phases of psychotherapeutic work, through the provision of a protected setting and a team approach, in conjunction with individual psychotherapy. A perspective is offered for conceptualizing the early relationship between patient and hospital staff as a stage in the development of an alliance.

Adult↗
PubMed1984

Implications of tumor growth rate for the natural history of lung cancer.

The growth rate of lung cancer may be described by an exponential model in which the volume doubling time, or growth rate, is constant. The doubling time may vary from case to case by an order of magnitude so it is probably the most important factor in the natural history of the disease. While some aspects are uncertain, the exponential model seems to be reasonably valid because it is coherent with what we already know about the course of the disease. It helps explain the long interval between onset of carcinogen exposure and clinical manifestation, the reversibility of risk after cessation of smoking, the results of periodic roentgenographic screening, and the variability of prognosis. As a result, the exponential model has certain medicolegal implications.

Adenocarcinoma↗
PubMed1984

Cigarette smoke, asbestos, and small irregular opacities.

The long-term inhalation of cigarette smoke is associated with the appearance of diffuse small irregular opacities of mild profusion on chest roentogenograms of some subjects in a limited number of reports. Human histologic and experimental animal studies have shown the presence of pulmonary interstitial fibrosis. The radiographic abnormalities may be explained by interstitial fibrosis, although bronchiolar wall thickening may also be involved. Because asbestos causes diffuse pulmonary fibrosis, the literature was reviewed for evidence concerning an interaction between cigarette smoke and asbestos in the frequency of pulmonary asbestosis. A majority of 14 prevalence studies and 7 cohort studies of asbestos workers with information on smoking habits have shown a positive interaction between the 2 agents. The interaction appears to be additive rather than synergistic. Smoking may exert an effect on the frequency of pulmonary asbestosis by increasing the effective fiber dose retained in the lungs through interference with clearance.

Animals↗
PubMed1984

[2 or 4 daily doses of cimetidine in the treatment of gastric ulcer?].

In a randomized multicentre study of 149 patients with gastric ulcer the effect of 1000 mg cimetidine daily applied in four separate doses was compared to that of 400 mg cimetidine twice a day. In both patient groups similar healing rates were observed. 80.3% and 74.0%, respectively, of the ulcers healed within 6 weeks, and 93.8% and 90.3%, respectively, within 10 weeks. Abdominal pain and antacid consumption decreased under both regimens to a similar degree. Drug safety was good. Lower cost and simplicity in the administration make the b. i. d. regimen of cimetidine preferable to the q. i. d. regimen in the acute treatment of gastric ulcer.

Alcohol Drinking↗