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Biomedical subjects

W Weise

Publications and source records attributed to W Weise.

At least 73 records · Page 4Linked to original sources
PubMed1984

[Microsurgery of the fallopian tube].

9 per cent of all patients with female sterility are indicated to be operated on. After discussing the conditions for microsurgery the indications like salpingolysis, ovariolysis, fimbrioplasty, salpingoneostomia, anastomosis, conservative operations of ectopic pregnancy and endometriosis are argued in detail. Microsurgery improves pregnancy rates about 20 per cent. The principles of microsurgery should have a wider entrance in gynecologic operations.

Endometriosis↗
PubMed1984

[Report of 8 years' experience in the prenatal diagnosis of genetic defects. II. Results].

From 1113 prenatal diagnoses there were findings in 7.3 per cent indicating an abruptio of pregnancy. Definitely a termination was performed only in 5.3 per cent The birth of 17 children with autosomal trisomies (14 trisomy 21), of 5 children with gonosomal anomalies and of 9 children having neural tube defects could be prevented by prenatal diagnostics. In 2.6 per cent there were chromosomal aneuploidies. One trisomy 21 (0,1 per cent) we did not perceive. Diagnostics indicated by age was followed by pathological findings in 3.9 per cent. In every 25th women exceeding her 40th year of life a trisomy 21 could be detected prenatally. The repetition risk of a morbus Down amounts 0.5 per cent. Parental balanced translocations were hereditary in 42 per cent. In case of diseases hereditary by the X-chromosome a male karyotype could be proved in 36 per cent, but only 65 per cent of these women could determine on interruption of pregnancy. Neural tube defects had a repetition risk of 3.1 per cent. In 0.4 per cent the results of alpha-fetoprotein analyses were false positive. In 9 per cent there was an indication for interruption of pregnancy by amniofetography. But a diagnostic statement is possible after aminofetography only in 79 per cent and after fetocopy in 61.3 per cent. The risk of abortion following aminocentesis is 2.5 per cent (caused by aminocentesis in 0.6 per cent), but following aminofetography 11.2 per cent. In 0.3 per cent there were fetal injuries, among these one serious fetal cranial trauma developing into hygroma.

Abortion, Induced↗
PubMed1984

[Report on 8 years' experience in the prenatal diagnosis of genetic defects. III. Outcome of pregnancy].

The courses of 997 pregnancies out of 1113 prenatal diagnoses were analysed. The total rate of all fetal and neonatal losses is 11.6 per cent inclusively the therapeutically induced abortions. Peculiarities of our material are the shift to higher ages and the inclusion of pregnancies following amniofetography and fetoscopy. Without the last ones the perinatal mortality is 18.9 per thousand, the abortion rate is 2.6 per cent, the rate of premature deliveries (till the 37th gestational week) is 10.2 per cent and the rate of low birth weight babies below 2500 g is 6.1 per cent in connection with a frequency of caesarean sections of 9 per cent. 91 per cent of the newborns had Apgarscore of 8 to 10. The most favourable courses with an abortion rate of 2.2 per cent, a perinatal mortality of 11.8 per cent and a rate of low birth weight babies of 5.7 per cent are to be found following uncomplicated amniocentesis. Perinatal mortality is increased about the factor 10 combined with an threefold raise of prematurity in cases of brownish amniotic fluid. If the amniotic fluid was bloody and the repeated insertions during amniocentesis abortion rate is 10 per cent and perinatal mortality 44.4 per thousand. --3.2 per cent of pregnancies after fetoscopy are terminated by abortions. Perinatal mortality is 33.3 per thousand, the rate of low birth weight babies 26.7 per cent. Pregnancies following amniofetography have a most unfavourable course. The abortion rate is elevated to 11.2 per cent, perinatal mortality to 139.2 per thousand with a rate of low birth weight babies of 41.8 per cent. Following amniofetography every fourth newborn has a birth weight below 1500 grams.(ABSTRACT TRUNCATED AT 250 WORDS)

Abortion, Induced↗
PubMed1983

[Report on 8 years' experience in prenatal diagnosis of genetic defects. I. Indications and methods].

Prenatal diagnostic procedures were done following 1231 transabdominal amniocenteses in 1113 patients of a gestational age of 17.4 +/- 0.5 weeks. Partly parallel the following methods were used: 1218 estimations of alpha-fetoprotein, 903 chromosomal analyses, 89 amniofetographies, 40 fetoscopies and 7 estaminations of hormones, immunoglobulins and enzymes. Amniotic fluid could be obtained in 91.8 per cent with the first insertion of the needle, using the free-hand-needle-technique. In 8 per cent amniotic fluid samples were bloody. The amniocentesis had to be repeated in 7.6 per cent because of no growth of cells (6.3 per cent), or no amniotic fluid could be obtained (1.3 percent). In the average 14.9 +/- 8.1 metaphases were analysed and 2.9 +/- 1.1 karyogram were made. The organisation of prenatal diagnostics was explained. The indication was in 39.6 per cent the age, in 20.3 per cent the repeated risk of the birth of a fetus with trisomy 21. In 13.7 per cent there was an indication to estimate alpha-fetoprotein which was done nearly without exception for exclusion of neural tube defects. The prenatal determination of the fetal sex was necessary in 7.3 per cent in cases of X-chromosomal inheritable diseases. Previous deliveries of infants with malformation-syndrome or chromosomal trisomies like Edwards-or Patau-syndrome and radiation or chemotherapy of one of the parents were summarized under other indications (7.3 per cent). Balanced parental translocations were the indication in 1.7 per cent. Amniofetography was used in 8 per cent of the patients to exclude malformations caused by prevalent multiple factors. It was in 35 per cent the prevailing diagnostic method. The set of problems of its use was discussed. Fetoscopy (3.6 per cent) partly was an additional diagnostic procedure partly a leading method. By means of a catalogue of indications it was referred to the use of fetoscopy to visualization in prenatal diagnostics. The exclusion of genetic metabolic defects was the motive to prenatal biochemic investigations in 0.5 per cent. The prerequisites of devices and technique to prenatal diagnostics were discussed.

Abnormalities, Multiple↗
PubMed1983

[Normal range values of uroflowmetry in comparison to findings in urinary incontinence].

The range of normal values of uroflowmetry is ascertained in 100 continent women and compared with the data of 40 women suffering from urinary stress incontinence. The mean volume of miction is 252 +/- 80 ml. The mean waiting time has a duration of 5 +/- 24 s. The mean time till a maximal urinary flow lasts 9 +/- 8 s. The maximal flow is measured 22 +/- 9 ml/s within a flow time of 25 +/- 13 s. The mean value of average urinary flow is 12 +/- 6 ml/s. The slope angle till the maximal flow independent of volume of miction is 65 +/- 18 degrees. Waiting time, time till maximal urinary flow and flow time are longer in incontinent women significantly. The volume of miction is greater, the maximal and average urinary flow, the slope angle till the maximal flow are lower significantly.--Uroflowmetry is a noninvasive method free of complications and indicated in cases of urinary incontinence, too. Above it is possible to diagnose obstructions of the lower urinary tract and dyssynergismus of the detrusor. For complete urologic diagnostic a combination with other methods is necessary.

Female↗
PubMed1983

[Significance of chromosome analysis in habitual abortion].

Between 1973 and 1981 94 married couples and 13 women with habitual abortion were investigated cytogenetically. -- We found six chromosomal translocations (two translocations of Robertson type and four autosomal reciprocal translocations). Five individuals had typical variants of heterochromatin.

Abortion, Habitual↗
PubMed1983

[Modifications of embryo and oocyte transfer in humans and our initial experiences].

The principal different readings of transplantation of human ova are explained: embryo transfer, artificial embryonation, extracorporal breeding and oocyte transfer. Our procedure of egg transfer is reported by means of 19 operations, consisting of implantation of preovulatory oocytes into the uterine tubes opened by microsurgery. One pregnancy only could be observed, but it was terminated by early abortion.

Embryo Transfer↗
PubMed1982

[Introduction of a Standardized "Paternity Index" for the Statistical Evaluation of Blood Group Findings in Paternity Testing (author's transl)].

The introduction of a standardized paternity in index (PI) for the statistical evaluation of blood group findings in cases of disputed paternity is proposed and explained. Using the PI X/Y as a parameter, it is not necessary to give the probability of paternity in percent. The PI includes the full information of the blood group findings. In addition to that, using the suggested standardization based on the probabilities of error according to Schulte Mönting and Walter, the test volume is also taken into account. The interpretation of the mathematical result is given by verbal predicates, the limitations of which are dependent on the verbal predicates for the probabilities of error according to Schulte Mönting and Walter, published by us previously. Besides the essential fact that the test volume is taken into account, the most important advantage of this procedure is that the mathematical result is involved in the court decision only by the PI (which is free of any valuation) and its verbal predicate and not by sometimes relatively high percentages, which may be misunderstood by laymen.

Blood Group Antigens↗
PubMed1982

[Therapeutic results obtained from women with functional sterility. First communication: combined oestrogen-gestagen therapy (author's transl)].

Combined oestrogen-gestagen preparations were applied to 169 women who had been sterile for an average period of 2.5 years, between 1975 and 1979. Their uncorrected pregnancy rate was 19 per cent. Pregnancy rates were 25 per cent for women who desired to have children up to two years or six per cent for those who tried longer. Oestrogen-gestagen therapy was successful in 20 per cent of women up to 30, but only in nine per cent of those beyond that age limit. Best therapeutic results were 45 per cent in cases of secondary amenorrhoea and 35 per cent in cases of genuine corpus luteum insufficiency. Anovulation, disorders of menstrual regularity, and Stein-Leventhal syndrome proved to be unfavourable conditions for this kind of therapy. The course of pregnancy was not accompanied by peculiarities of extraordinary dimensions. Combined oestrogen-gestagen treatment was found to be an appropriate initial therapy, within WHO Group II, for secondary (post-pill) amenorrhoea and corpus luteum insufficiency. While the presence of additional sterility factors does not necessarily mean contra-indication, prospects of success are reduced.

Adult↗
PubMed1982

[Therapeutic results obtained from women with functional sterility. Third communication: gonadotrophin therapy (author's transl)].

Gonadotrophin treatment was given to 81 patients with functional sterility. Individualised dosage proved possible, depending on close therapeutic monitoring. General input can be rationalised along with growing experience.--WHO Group I included 7.4 per cent of the patients reviewed. The pregnancy rate of this Group was 83 per cent. WHO Group II included 90.4 per cent. Their pregnancy rate was 37 per cent. Clomiphene failure was recorded from 79 per cent of the patients. The overall pregnancy rate amounted to 39.5 per cent, even with additional presence of tubal and andrological sterility factors. Overstimulation was recordable from 18.5 per cent of the probands. Multiple pregnancy occurred to 9.4 per cent. Rates of abortion could be kept as low as 9.4 per cent by early sick leave and progesterone substitution.--Young age of patient, short time of desire of children, and hypogonadotrophic normoprolactinaemic amenorrhoea proved to be the most favourable set of indications for gonadotrophin therapy.

Adult↗
PubMed1982

[Therapeutic results obtained from women with functional sterility. Second communication: clomiphene therapy (author's transl)].

Reported in this paper are results obtained from treatment of 246 patients for sterility in WHO Group II to whom clomiphene had been applied. Some of these patients had been earlier treated without success, using combined oestrogen-gestagen preparations. Primary sterility was manifest in 86 per cent of the cases, and biphasic cycle was recorded from 95 per cent of the probands.--The pregnancy rate was 30.1 per cent, but 22 per cent of pregnancies ended in abortion. Multiple pregnancy was observed in four per cent. Minor side effects occurred in 1.2 per cent of the cases.--Best results were 36 per cent in cases of secondary amenorrhoea and 32 per cent in cases of anovulation. Sixty-six per cent of all pregnancies occurred in the first three cycles of treatment. Eight per cent of the women grew pregnant six months within discontinuation of clomiphene medication. An unambiguous interdependence was found to exist between age of the patient, length over time of desire of children, and rate of conception. The pregnancy rate fell to 15 per cent in women beyond 30 years of age. A pregnancy rate of 35 per cent was achieved in 110 women in whom sterility had been solely caused by functional aspects, while 27 per cent were achieved for couples with additional fertility-depressing factors. Moderate increase of clomiphene doses, homologous insemination, and flanking HCG injections helped to improve success of the basic therapy to the order of 119 per cent.--Efforts in terms of monitoring and general therapeutic input are higher than those associated with ovarian hormone therapy of sterile couples, though justified by better results.

Abortion, Habitual↗
PubMed1982

[Autosomal translocation in gynaecology and obstetrics. 1. Reproduction behaviour and chance of chromosomal translocation carriers (author's transl)].

Nineteen chromosal translocations (1.8 per cent) were recorded from 1,055 chromosomal analyses, between 1972 and 1980. Three translocations were unbalanced. Their carriers were no longer suitable for reproduction for the severity of their chromosomally caused disorders. Another three translocation carriers declined to have children of their own by voluntary decision or due to functional disorders, although they had been carriers of balanced translocations. Thirteen translocation carriers insisted on having children. With 41 pregnancies reviewed, abortion was the result of 58.5 per cent, birth of still malformations of 12.2 per cent, birth of living malformations in 7.3 per cent, and birth of clinically intact children in 22 per cent (three cases of balanced translocation). There were five D/G translocations and three D/D translocations. All the other translocations were singular. Only one in seven pregnancies of D/G translocation carriers (4 +/- 0.8) resulted in the birth of a clinically intact child. One in three pregnancies of other translocation carriers (2.6 +/- 0.3) yielded the same result. Female translocation carriers were 1.6 times as frequent as males. Their rates of abortion and malformation were twice as high as those of other women. -Clinically intact children were born only to nine of 13 couples, notwithstanding prenatal diagnosis. Handicapped children were recorded from 23 per cent of the couples reviewed. The need is emphasised for psychological guidance of such couples which should be offered by the attending gynaecologist.

Abortion, Spontaneous↗
PubMed1982

[Autosomal translocation in gynaecology and obstetrics. 2. Cytogenetic findings (author's transl)].

Reported in this paper are cytogenetic findings obtained from 19 cases of translocation in gynaecological and obstetric patients which had been recorded from 1,055 chromosomal analyses. The translocations are defined in some detail. Twelve of them were of the Robertson type and three unbalanced, while the origin of one "de novo" 4p+ translocation was not elucidated. The breaks in reciprocally balanced translocations were related to various chromosomal sections, but A chromosomes were involved in four cases. The relevance of cytogenetic studies into gynaecologico-obstetric patients is discussed with reference to the above findings.

Adult↗