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Biomedical subjects

W Weise

Publications and source records attributed to W Weise.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Quantitative detection of spermatogenesis cells and qualitative assessment of meiosis stages in the ejaculate of normo- and oligozoospermia].

Meiosis examinations in semen have been aspired in 106 patients of an andrologic outpatient clinic. Diakinesis and metaphase could be represented in 15 per cent. No meiosis analysis was possible in 12 per cent of the males. The increase of the immature spermatozoa count from 8 per cent in case of normozoospermia to 55 per cent in oligozoospermia III. degree was highly significant. Better quality of meiosis representation correlated to the increasing number of spermatogenesis cells.

Adult↗
PubMed1988

[Safety of separation of maternal and fetal tissue in chorionic biopsy material as a prerequisite of prenatal gene diagnosis].

198 tissue samples from over all 336 chorionic biopsies obtained by different techniques had been examined histologically. Decidual residues could be found in 37 per cent of the specimens in spite of a twofold estimation of vitality. In correlation our increasing experience the frequency of decidual contamination decreased from 60 to 17 per cent. At the end of our examinations in only 5 per cent of 1,998 microscopic visual fields decidua could be found. This decidual contamination may be reason for misinterpretation of results. This error of the method has to be taken into consideration in all prenatal diagnostic statements especially in DNA- and enzymatic diagnostics.

Biopsy↗
PubMed1988

[Tubal transplantation in the treatment of sterility].

The methods of tubal transplantation, tubal transposition, artificial tube and transposition of ovary and uterine cornu have been described in a historic survey. An allogenous tubal transplantation today because of the risk is not indicated but on the other hand autologous transplantations or transposition of the tube may be done in single cases. Precondition for that is a good microsurgery team which includes one vascular surgeon.

Fallopian Tubes↗
PubMed1986

[Fractionated curettage without uterine specimen. What to do?].

In 143 (1.2%) out of 12,357 curettages from 1970 to 1982 we could not get specimens from the corpus. In 7 cases cervix curettage showed suspect tissue therefore no corpus curettage has been done. In 4 cases the corpus uteri has been perforated. Indication was postmenopausal bleeding in 119 patients. In 50 per cent the gynaecologist was to timorous because of a length of more than 7 cm. In 5% a carcinoma of corpus uteri could be found within one year. In 42 per cent the cause of not having specimens was an atrophic uterus. Altogether we had 4% carcinomas of the corpus uteri in the sample. In 80 per cent of the postmenopausal bleedings a control examination within 6 to 8 weeks detected the malignancy. Therefore a D & C for exclusion of carcinoma is to be estimated as an incomplete one, if there is no tissue from the corpus. A control is necessary principally.

Adult↗
PubMed1986

[Incidence and pregnancy rates in various causes of sterility].

A precise diagnostic procedure could be done in 1,450 sterile couples in the years 1975 to 1982. The prevailing cause of sterility was female in 67 per cent, male in 22 per cent and both female and male in 11 per cent. Pregnancy rate over all was 35 per cent and after therapy 45 per cent. There was a distinct correlation between pregnancy rate, age of the patient and duration of desire for child. 73 per cent of all conceptions occurred in female sterility; 77 per cent of it in ovarian sterility. Simple therapeutic methods like gestagens or clomiphene and conversational therapy achieved the highest pregnancy rate. Only a little proportion of the pregnancy rate could be obtained by highly specialized measurements like FSH/HCG (7 per cent) or operative interventions (8 per cent). In cases of male reasons only 8 per cent of all pregnancies could be attained. 62 per cent of all pregnancies supervised were live births. Because highly specialized methods are not able to influence the rate of conceptions over all embryo transfer will be more and more the alternative method in cases of sterile couples treated without success till now.

Adult↗
PubMed1986

[Regional transfemoral intra-arterial chemotherapy using selective catheter placement. Method and clinical results].

In a retrospective study on 108 arterial transfemoral perfusion treatments with cytostatic drugs, the authors describe the procedure and the response of patients shown by tumor markers, computed tomography, histologic findings, and subjective assessment by the patients. Then follows a critical discussion of the complication rate of a therapy which has proved since 1980 to be a valuable and effective treatment method. The objective remission rate was 67%, and a subjective response was observed in 75% of all cases. Compared to systemic chemotherapy, the tolerance was clearly better. Only in one case we found an arterial embolism which was treated by conservative measures. Intraarterial perfusion of cytostatic drugs is within the scope of palliative measures a very effective and, above all, relatively non-stressful treatment with regard to quality of life and survival time. This interventional therapy method should be offered by the radiologist to the clinical oncologist.

Adult↗
PubMed1985

[Abortion following prenatal diagnosis of genetic defects].

71 abortions after prenatal diagnosis of genetic defects have been performed between 1974 and 1983. Mean duration of pregnancy was 21 weeks, mean hospital stay 10 days. In 28 per cent an intraamnial prostaglandin induction was done, which was successful in 85 per cent. Extraamnial prostaglandin application was combined with oxytocin in 51 per cent, which was followed by abortion in 51 per cent within 26 hours. Primary hysterectomy was performed in 4 per cent and rupture of the membranes combined with oxytocin infusion in 6 per cent. Complication rate overall was 20 per cent. In 6 per cent the following complications have been observed: 1 perforation with lesion of intestine, 1 cervical rupture with hemorrhage, 1 colpaporrhexis, 1 shock. Pelveoperitonitis and rupture of the symphysis pubis in one case each (3 per cent). Other complications, like fever, hemorrhages and thrombophlebitis have been observed in 11 per cent. Midtrimester abortion after prenatal diagnosis of genetic defects should be done only in experienced clinics. Special importance in prophylaxis of complications of abortion has chorion biopsy to predate prenatal diagnosis in the 6th till 12th gestational week.

Abortion, Induced↗
PubMed1985

[Status of prenatal diagnosis using direct interventions on the fetus].

Prenatal diagnosis has developed into a large flourishing multidisciplinary branch of medicine. At present prenatal diagnosis is world-wide possible in the second trimester of pregnancy by analysis of both amniotic fluid obtained by amniocentesis or amniotic cell cultures. Ultrasound plays a central role in prenatal diagnosis, and has revolutionized obstetric practice. Without dealing with all aspects of prenatal diagnosis we have discussed the following invasive procedures, which give the prenatal diagnosis its forward thrust: fetal blood sampling including intravascular transfusion, fetal skin-, liver- and muscle biopsy, chorion biopsy, selective birth in twin pregnancies, and fetal therapy including fetal surgery. In utero surgery is in its earliest stages. Such simple procedures as decompression of the hydronephrotic kidney in obstructive uropathy, of the fetal lungs in pleural effusions caused by chylothorax, or of the hydrocephalic ventricle may be useful, but the possible success rate for such efforts remains still uncertain. The possibilities of first-trimester prenatal diagnosis especially by DNA-technology or direct chromosomal and biochemical analysis has stimulated the development of a multiplicity of methods for taking chorion biopsies. Compared with second trimester amniocentesis, the introduction of prenatal diagnosis by chorionic villi sampling would reduce the psychic trauma for patients waiting on results and allow earlier and safer termination of pregnancy.

Biopsy↗
PubMed1984

[Growth behavior of amnion cell cultures].

Both amniotic fluid samples and amniotic fluid cell cultures of a total of 52 patients were evaluated. At 15 to 16 weeks' gestation there are 2.2 X 10(4) cells/ml amniotic fluid increasing significantly to 3.7 X 10(4) cells/ml at 19 to 20 weeks' gestation. The percentage of viable cells is about 18. After 10 d of culture 14.4 +/- 8.2 cell colonies/culture flask are developed consisting of 61% AF-cells, 33% E-cells and 6% F-cells. After 14 d of culture 60 +/- 32 metaphases/cell culture flask were found. At the 10th day of culture 80% of cell colonies are already present indicating that reduced duration of culture appears possible. Therefore the interval to diagnosis can be shortened and a possible interruption of pregnancy can be earlier done under reduced risks.

Amniocentesis↗